PHYSICS OF BIOLOGICAL SYSTEMS – ph549 LECTURE 9 – Energy and Equilibrium
LIFE and ENERGY Electromagnetic Energy Chemical Energy Mechanical Energy Thermal Energy
Equilibrium and Non-equilibrium
Equilibrium and Non-equilibrium Rob Philips, Physical Biology of the Cell
Free Energy Minimization Folding of proteins into the native state
Free Energy Minimization Labro et. Al. Frontiers Pharmacology (2012) Gating of Ion Channels
Free Energy Minimization Lim et. al. PNAS, 99, 16766 (2002) Shapes of red blood cells
The Entropic dance F = E - TS Bo Peng (UMass Amherst)
Binding of RNA Polymerase
Binding of RNA Polymerase
Binding of RNA Polymerase
LIGAND Receptor Binding Barakat et. al. Recept. Clinic Invest. (2015) Haemoglobin
LIGAND Receptor Binding
LIGAND Receptor Binding Cairo et. al. Princ. Pharma (2012)
Translation and Transcription
Binding of RNA Polymerase
Origins of Hydrophobicity
References and further reading Physical Biology of the Cell – Rob Phillips et. al. Chapters 5 and 6 Biological Physics – Energy, Information, Life – Phil Nelson Chapter 6
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