Parentage Verification Development of new ICAR and Interbull - PowerPoint PPT Presentation

Parentage Verification Development of new ICAR and Interbull services: GenoEx-PSE and ICAR Accreditation

Outline Background 1 Interbull Centre 2 GenoEx-PSE 3 ICAR Accreditation 4 Service Users 5 Conclusions and benefits 6

Interbull Centre Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala, Sweden

Interbull Centre • Operational unit of Interbull – a permanent sub-committee of the International Committee for Animal Recording (ICAR) • European Union Reference Laboratory (EURL) for Zootechnics (Bovine Breeding) • ISO 9001:2008 certified.

Interbull / Interbull Centre Supporting dairy and beef industry: • Accurate genetic information on bulls • Dairy and beef; 35 Countries; Since 1996 • Enabling importers and exporters to select, worldwide, the best genetics for different countries, environments or breeding goals • International Genetic and Genomic Evaluations: • Interbull “MACE”, “GMACE”, “InterGenomics”; Interbeef

Interbull / Interbull Centre • Infrastructure and expertise for International Data Exchange and Quality Assurance: • Processes GBR GBR • Standards HUN HUN USA USA • Protocols • Code or Practice Interbull AUS AUS NED NED Etc Etc

Parentage Verification • Breed associations globally have been manually sharing microsatellite profiles as a process for maintaining herd book integrity. • SNP genotypes more accurate than microsatellite profiles for confirmation of parentage • International exchange of SNP genotypes for parentage analysis provides benefit to wide group of ICAR member countries

GenoEx-PSE - principles GENOEX-PSE • Is a tool to facilitate ( not a replacement for national authorities ); • Interbull Centre will not have the right to do parentage analysis; • SNP exchange ONLY for parentage analysis; • Verification, discovery, imputation for subsequent verification • Currently only cattle: both dairy and beef; • A voluntary initiative; • National responsibilities will remain where they are now.

Target Animals • “Targeted” animals to be routinely uploaded: • AI sires and their dams • Foreign-born sires with daughters born in your country • Parents of animals born by embryo transfer (ET) • Other special cases as needed

ICAR Accreditation • ICAR has existing accreditation procedures for laboratories processing DNA into genotypes • New ICAR accreditation service will be introduced in conjunction with GenoEx-PSE • Accreditation for DNA Data Interpretation Centres • Initial application followed by a accreditation renewal every two years • Prerequisite to join GenoEx-PSE

Service Users • Interbull Users and ICAR Members: • Only service users with signed agreement can upload and download data • Can only download SNPs in accordance with what they upload • Organizations officially in charge of parentage certification in each of the ICAR member countries, or otherwise traditionally providing parentage certificate • Organizations that in their capacity as the official body in charge of genetic/genomic evaluation services • ICAR/ISAG accredited laboratories that are under contract with the organizations identified in 1 or 2 above

Service Users; Obligations Service Users must: • Upload regularly (at least 3x per year) • Report conflicts identified via GenoEx-PSE to the authorised organisation • Follow ICAR rules, regulations and policies • GenoEx-PSE rules • Pass ICAR accreditation for DNA Data Interpretation Centre • Maintain the accreditation status • Not use for other purposes than Parentage Analysis • Not share/exchange data with third party

Exchange of SNPs – before GenoEx-PSE GBR GBR HUN HUN USA USA AUS AUS NED NED Etc Etc

Exchange of SNPs – before GenoEx-PSE GBR GBR HUN HUN USA USA GenoEx- PSE AUS AUS NED NED Etc Etc

Concusions and benefits National responsibilities will remain where they are now. MULTILATERAL SNP DATA EXCHANGE by establishing a common repository and customer driven access rules: • Countries with national genomic evaluations would already be doing Parentage Analysis • Have genotypes for essentially all dams and AI sires • Potentially missing genotypes for some sires • Quicker/smoother transition from use of microsatellite to use of SNPs • Optimize customer investments in genotyping by avoiding duplication • AI bull owners will have more accurate identity of daughters in countries importing semen

Thank you.