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IP M ANAGEMENT @ U NIVERSITIES 30-31 O CTOBER 14 Boazii University, Istanbul, Turkey U NIVERSITY -I NDUSTRY P ARTNERSHIPS : S UCCESS S TORIES C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP A M ODEL TO C OMMERCIALIZE A

  1. IP M ANAGEMENT @ U NIVERSITIES …30-31 O CTOBER ’14 Boğaziçi University, Istanbul, Turkey “U NIVERSITY -I NDUSTRY P ARTNERSHIPS : S UCCESS S TORIES ” C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP A M ODEL TO C OMMERCIALIZE A CADEMIC IP By B ANU O NARAL , P H D S ENIOR A DVISOR – S TRATEGIC P ARTNERSHIPS T EKNOPARK I STANBUL , T URKEY & H. H. S UN P ROFESSOR AND D IRECTOR A ND D AVOOD T ASHAYYOD C OULTER P ROJECT D IRECTOR S CHOOL OF B IOMEDICAL E NGINEERING , S CIENCE AND H EALTH S YSTEMS D REXEL U NIVERSITY P HILADELPHIA PA, USA

  2. F USING A CADEMIC AND B USINESS C ULTURES TO COMMERCIALIZE UNIVERSITY RESEARCH  Unmet clinical need  Assemble all those who bring value to commercialization – Academics bring scientific and technological goods – Industry provides commercialization means – Shared mission implemented through concrete projects  Entrepreneurs, lawyers, business and economic development professionals and investors embedded in the academic trenches Project management discipline is a MUST  One size does not fit all – local rules of engagement

  3. D IMENSIONS O F T RANSLATIONAL R ESEARCH Road map to accelerate commercialization of university innovation • De-risking process that brings university biomedical innovations to a critical endpoint • Compressed timelines and laser focus effort • Attract follow-on funding from ‘professional investors’ or industry: SUCCESS METRICS Project Management • Office of Coulter Project Director • Deliverables, Milestones & Budgets Due Diligence • Market Research – Go/No Go • IP – Patentability & F reedom to Operate • Regulatory Pathway • Reimbursement Diligence is the mother of good luck Benjamin F ranklin (Poor Richard's Almanack, 1736)

  4. A T RANS F ORMATIVE P ARTNERSHIP A N ATIONAL B EST P RACTICE … that fuses academic and business cultures Starting in 2006 Boston University  Case Western Reserve University  Drexel University*  Duke University  Georgia Technology Institute  University of Michigan  Stanford University  University of Virginia  University of Washington  University of Wisconsin  J oined in 2011 Columbia University  J ohns Hopkins University  University of Louisville  University of Missouri  “ Science serves humanity” University of Pittsburgh  University of Southern  California …Address unmet needs in healthcare

  5. F RAMEWORK Working Hypothesis  An industry like approach for product development  Can be established in the universities  Will accelerate the translation of innovation to market place Investment Guidelines  Develop products for the improved management of unmet or poorly met clinical needs:  For any significant medical problems or diseases  Demonstrable clinical impact and improve patient lives  Invasive and non-invasive medical devices  Diagnostic or therapeutic technologies  Clinical software  Hybrid hardware-software systems

  6. O UR E XPANDING C OMMERCIALIZATION C OMMUNITY Drexel Partners R ETHINKING P HILADELPHIA ✓  Medicine; Public Health; Nursing and Health Professions; Arts and R EINVENTING P HILADELPHIA ✓ Science; Engineering; Information Science; Media Arts and Design; Business and Law A CTION P HILADELPHIA Economic Development Agencies & Trade  Organizations Ben Franklin Technology Partners, BioAdvance, PA Bio, Philadelphia NOW! Industrial Development Corporation, Select Greater Philadelphia, University City Science Center… Corporate Partners  Exponent, Integra Life Sciences, Shire, Johnson and Johnson… Institutional Partners  …W HE R E IT ALL BEGAN Children’s Hospital of Philadelphia (CHOP); Fox Chase Cancer Research Institute; Good Shepherd Rehabilitation Network; Inglis Foundation; Lankenau Hospital; Monell Chemical Senses Center; Shriners Hospitals for Children; Thomas Jefferson University; University of Pennsylvania; Wistar Institute… Business Development, Legal and Investment  Partners… Alumni and F riends… …State of Pennsylvania and F ederal Agencies

  7. W HY D REXEL ? • Misssion & Mandate: Relevance to the clinic and the industry • Translational research track record • Multi-disciplinary and multi-institutional culture • end to end solutions • Committed to engagement with industry and investment community • Access to a far-reaching network of innovation partners Global Innovation Partners Turkey: Regional health innovtion movements: INOVIZ, INOVAnkara, INOVITA… Teknopark Istanbul, OSTIM, DEpark, EGE Teknopark… + Regional Innovation Partners China: Shanghai Jiao Tong University – Med-X Research Institute, Dual PhD; Drexel - Shanghai Advanced Research Institute (SARI) Israel: Hebrew University - Institute for Drug Research; Hadassah Medical Center; Yissum Technology Transfer; Haifa University – Edmond J. Safra Brain Research Center

  8. I MPACT I NVEST  I MPLEMENT  L EVERAGE  O UTCOMES N ATIONAL C OULTER T RANSLATIONAL R ESEARCH - P ARTNERSHIP O UTCOMES 6 TH Y EAR A UDITED R ESULTS (A S OF D ECEMBER 31, 2012) Number of US$ in million projects Funded projects ~250 56 VC funding 40 352.2 Repeat VC funding 13 119.4 New VC funding 12 79.9 Industry 29 Success rate to license to VC/A 27.6% funded startup or Industry Projects in clinical trials 11 Partial reporting Projects in the market Partial reporting 9 ROI ~7X

  9. I MPACT I NVEST  I MPLEMENT  L EVERAGE  O UTCOMES 2006 - 11 Commercialization Outcomes • 31 Technologies supported and 10 Technologies seeded • Patents: Invention disclosures 57; Patent applications 91; Issued patents 19 • 12 Technologies licensed (2 Technologies licensed to regional companies - 2 Drexel students hired by regional licensees) • $31M of follow-on funding raised Community Impact • Industry and Corporate Innovation Partnerships • Regional, National and Global Innovation Partnerships    D REXEL I NNOVATION N EIGHBORHOOD

  10. C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP - L ICENSED T ECHNOLOGIES • VEUSim: A Virtual Endovaginal Ultrasound Simulator for Physician Training • LCL Grafts: Innovative Small Caliber Vascular Grafts for Coronary Bypass • Optical Diagnosis and Treatment Optimization in Chronic Diabetic Wounds: A Pilot Clinical Study • Living Tissue Sterilization by the Dielectric Barrier Discharge Plasma • Cardiac Biomarker Detection using Q-DOT Immunoassay QLIDA

  11. C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP - L ICENSED T ECHNOLOGIES • Bioactive Alimentary Protein-Based Scaffolds (APS) for Wound Healing • Electronic Blood Pressure Wristwatch • Portable Breast Cancer Screening by Elasticity and Mobility Measurement to Locate Tumor Malignancy • Syk Kinase as a Biomarker of Skin UV Damage and Photocarcinogenesis • Biomimetic Aggrecan Injection

  12. C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP - L ICENSED T ECHNOLOGIES • Real-time Seizure Detection and Control System using Our Patented Ceramic-base Multisite Electrode • F unctional Near-infrared Spectroscopy as a Monitor for Depth of Anesthesia • Fast Plasma-assisted Hand Disinfection or Sterilization System • Quantum Dots for interaoperative Margin Determination during Breast Cancer Surgery • Non-Invasive Hand-Held Brain Edema Monitoring System

  13. C OULTER -D REXEL T RANSLATIONAL R ESEARCH P ARTNERSHIP - L ICENSED T ECHNOLOGIES • Maternity " Smart F abric Bellyband " to Monitor Uterine Activity and Assess Fetal Well-being • Ultrasound for Localizing Endotracheal Tubes (ETTs) in Neonates • Diagnosis of Tissue Damage (Bed Sores) from Micron to Centimeter Depths Using Non-Contact Near Infrared • Nanoscale Thin Coatings for Neural Prostheses (Seed) • Functional Near-infrared Spectroscopy for Assessment in Schizophrenia (Seed) • Injectable Hydrogel Loaded with Particles Releasing Minocycline for Spinal Cord Repair (Seed) • Plasma-activated Antimicrobial Wound Dressing (Seed)

  14. C H R ONOLOGICAL P E R SPECTIVE OF T R ANSLATIONAL R ESEA R CH AT D R EXEL U NIVE R SITY • B iomedical Engineering and Science Institute founded, 1960 • R eorganized as the School of B iomedical Engineering, 1998 – New mission: Move discoveries to healthcare • Alumni participation - First Entrepreneurship in B iomedical Engineering course taught, 2000 • Outreach to university and regional partners (other universities, research institutes, development agencies), 2001 • T echnology T ransfer Office established – One licensing professional, 2004 • Coulter T ranslational Partnership Program announced, 2004 • Coulter T ranslational Partnership Competition (80 Universities), 2005 • D rexel wins the Coulter T P award together with 9 other Universities (Conditional on recruitment of additional licensing professionals), 2006 • R ob Loring, an Alumnus, serves as the first Coulter Project D irector • Coulter Endowment awarded to D rexel and 4 other schools, 2011

  15. H OW TO G ET I NVOLVED Collaborative Research Programs Oversight Committee Service • Advise & Mentorship • Consultant / Business Advisor • Out-licensing • Option Agreement • License Agreement • Sponsored Research Agreement

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