Meeting Program Sunday 2:00 pm - 9:00 pm Arrival and Check-in - PDF document

Phosphorylation and G-Protein Mediated Signaling Networks Gordon Research Conference Regulation and Inter-Connectivity of Kinases, Phosphatases and G-Protein Mediated Signaling Pathways in Health and Disease June 3-8, 2018 University of New England Biddeford, ME Chair: Anton Bennett Vice Chair: Rebecca Berdeaux Contributors IGIA Pharmaceuticals, Inc.

Meeting Program Sunday 2:00 pm - 9:00 pm Arrival and Check-in 6:00 pm Dinner 7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff 7:40 pm - 9:30 pm Keynote Session: The Hub of Signal Integration Discussion Leader: Anton Bennett (Yale University, USA) 7:40 pm - 7:50 pm Opening Remarks 7:50 pm - 8:00 pm Introduction by Discussion Leader 8:00 pm - 9:00 pm Melanie Cobb (University of Texas Southwestern Medical Center, USA) "Environmental ERKonomics" 9:00 pm - 9:15 pm Discussion 9:15 pm - 9:30 pm General Discussion Monday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Metabolism: Ying and Yang of Metabolic Signaling Networks Discussion Leader: Carol Williams (Medical College of Wisconsin, USA) 9:00 am - 9:30 am Sorin Tunaru (Max Planck Institute for Heart and Lung Research, Germany) "Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA) "Kinase-Mediated Regulation of Muscle Glucose Disposal" 10:10 am - 10:20 am Discussion 10:20 am - 10:30 am Selected from Poster Abstracts: Lasse Bak (University of Copenhagen, Denmark) "AMP Kinase-Mediated Selective Activation of Astrocyte Glycolysis via Phosphorylation of PFKFB3 as a Novel Therapeutic Approach in Alzheimer's Disease" 10:30 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:35 am Matthew Spite (Harvard Medical School / Brigham and Women's Hospital, USA) "Inflammation-Resolving Lipid Mediators and Their Receptors" 11:35 am - 11:45 am Discussion

11:45 am - 11:55 am Selected from Poster Abstracts: Ahmed Lawan (Yale University, USA) "Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance" 11:55 am - 12:00 pm Discussion 12:00 pm - 12:10 pm Selected from Poster Abstracts: Nicole Tensmeyer (Brigham Young University, USA) "Chaperone Mediated Assembly of mTOR Complexes" 12:10 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Ranga Rajan (University of North Carolina at Chapel Hill, USA) "An Alternative G Protein Signaling Pathway Leads to Autophagy in Saccharomyces cerevisiae " 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 3:00 pm - 4:00 pm Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA) 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner 7:30 pm - 9:30 pm Neuroscience: Wiring the Neuron by Phosphorylation and G- Proteins Discussion Leader: Alan Smrcka (University of Michigan, USA) 7:30 pm - 8:00 pm Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA) "Loss of Opioid and Gi-Dependent Inhibition of Adenylyl Cyclase After Spinal Cord Injury" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:40 pm Linda Van Aelst (Cold Spring Harbor Laboratory, USA) "Rho Regulator-Mediated Signaling in Inter-Neuron Development and Disease" 8:40 pm - 8:50 pm Discussion 8:50 pm - 9:00 pm Selected from Poster Abstracts: Smita Yadav (University of Washington, USA) "Unmasking Aberrant Phosphorylation Networks in 16p11.2 CNV Associated Autism" 9:00 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Short Talk Selected from Poster Abstracts 9:15 pm - 9:20 pm Discussion

9:20 pm - 9:30 pm General Discussion Tuesday 7:30 am - 8:30 am Breakfast 8:30 am Group Photo 9:00 am - 12:30 pm Lipids Linking Signaling Discussion Leader: Kun-Liang Guan (University of California, San Diego, USA) 9:00 am - 9:30 am Jonathan Backer (Albert Einstein College of Medicine, USA) "PI3Kbeta Signaling in Invasion and Metastasis" 9:30 am - 9:40 am Discussion 9:40 am - 9:50 am Selected from Poster Abstracts: Mathew Tantama (Purdue University, USA) "Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics" 9:50 am - 9:55 am Discussion 9:55 am - 10:25 am Lloyd Trotman (Cold Spring Harbor Laboratory, USA) "PTEN and the Digital Signaling Hub" 10:25 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:15 am Selected from Poster Abstracts: Alexey Bondar (Augusta University, USA) "Gs Protein Subunits Avoid, but Are Not Excluded from, Clathrin-Coated Pits" 11:15 am - 11:20 am Discussion 11:20 am - 11:30 am Selected from Poster Abstracts: Shelley Hooks (University of Georgia, USA) "RGS10 Regulates COX-2 and TNFalpha Through G Protein Independent Mechanisms" 11:30 am - 11:35 am Discussion 11:35 am - 12:05 pm Aashish Manglik (Stanford University, USA) "Structural Basis of Opioid Receptor Function" 12:05 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Selected from Poster Abstracts: Yingrong Xu (Pfizer, USA) "Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre- Coupled Receptors" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session 6:00 pm Dinner

7:30 pm - 9:30 pm Cardiovascular System and Vascular Networks Discussion Leader: Gregory Tall (University of Michigan, USA) 7:30 pm - 8:00 pm Alan Smrcka (University of Michigan, USA) "Subcellular Control of Phospholipase Cepsilon Signaling in Cardiac Function" 8:00 pm - 8:10 pm Discussion 8:10 pm - 8:20 pm Selected from Poster Abstracts: Jaesung Yi (Yale School of Medicine, USA) "PZR Tyrosyl Phosphorylation Is Associated with Hypertrophic Cardiac Gene Expression in Shp2 Associated NSML Model Mice" 8:20 pm - 8:25 pm Discussion 8:25 pm - 8:55 pm Thomas Rich (University of South Alabama, USA) "High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells" 8:55 pm - 9:05 pm Discussion 9:05 pm - 9:15 pm Selected from Poster Abstracts: Nariman Balenga (University of Maryland School of Medicine, USA) "G-Protein-Dependent and -Independent Signaling of Orphan Adhesion GPCR, GPR64" 9:15 pm - 9:20 pm Discussion 9:20 pm - 9:30 pm General Discussion Wednesday 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Visualization and Model Systems in Signaling Discussion Leader: Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA) 9:00 am - 9:30 am Jin Zhang (University of California, San Diego, USA) "Spatial Compartmentalization of Second Messengers and Kinase Complexes in Living Cells" 9:30 am - 9:40 am Discussion 9:40 am - 10:10 am Henrik Dohlman (University of North Carolina at Chapel Hill, USA) "G Protein-Mediated Autophagy in Yeast" 10:10 am - 10:20 am Discussion 10:20 am - 10:30 am Selected from Poster Abstracts: Pascale Charest (University of Arizona, USA) "Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre- Coupled Receptors" 10:30 am - 10:35 am Discussion 10:35 am - 11:05 am Coffee Break 11:05 am - 11:15 am Selected from Poster Abstracts: Chuan-Hsiang Huang (Johns Hopkins University, USA) "Integrating Chemical and Mechanical Signals Through Dynamic Coupling Between Protrusions and ERK Activation"