Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen Ov - PowerPoint PPT Presentation

Matthew Bollom, Vanessa Grosskopf, Samantha Paulsen, Jeff Theisen

Ov Over ervi view w ž Background and Motivation ž Design Specifications ž Previous Work ž Semester Goals — Staple Fabrication — Stapler Design ž Future Work

Bla ladder C Canc ncer ž Client: Dr. Tracy Downs, Professor of Urology, University of Wisconsin Clinics ž 5 th most common cancer in United States 1 ž Most expensive over time ž Treatment when cancer invades muscle: radical cystectomy 2 — Urostomy bag — Neobladder

Motivation & n & P Proble lem S m Stateme ment nt ž Ureters attached to new bladder via absorbable sutures ž Lengthy procedure ž Inconsistency between surgeons ž Metal staples cause stones ž Minimize subsequent interventions

De Design S n Specifications ns - S - Staple les ž Biocompatible ž Secures ureter to neobladder for a minimum of 30 days ž Able to create water-tight seal ž Withstands bladder environment ž Does not damage surrounding tissue ž Sterile

De Design S n Specifications ns - S - Staple ler ž Must be faster and more consistent compared to sutures ž Sterile ž Firing mechanism must be simple to operate ž Must form water-tight seal of ureter to neobladder

Previous W Work - S k - Staple les ž 85:15 poly(lactide-co-glycolide) ž Biocompatible and absorbable ž Barbs for gripping tissue http://www.wako-chem.co.jp/specialty/plga/index.htm

Previous W Work - F k - Fabrication n Problem: bubbles in material plate and staples

Previous W Work - T k - Testing ng staple Problem: bubbles in test specimens, non-physiologically relevant tissue model

Previous W Work - S k - Staple ler Problem: not compatible with our staple design

Seme mester Go Goals ls ž Improve staple fabrication – remove bubbles ž Develop stapler prototype ž Integrate staples with stapler ž Functional testing of staples and stapler with physiologically relevant model

Staple le F Fabrication n ž PLGA film deposition via chloroform evaporation — Film is too flimsy — Cannot be compression molded — Possible degradation or increased porosity

Staple le F Fabrication n ž Possible approaches — Compression molding in a vacuum — Injection molding — New aluminum mold ○ Shallow enough so we can squeeze out bubbles — Plastic mold (PMMA) — PMMA staples for functional testing and validation of staple design

Staple ler A Approach h

Ring Clamp Staple ler A Approach h Anvil Sheath Center Bar Cartridge

Staple ler A Approach h

Staple ler V Video

Future W Work k ž Attempt other suggested methods to get rid of bubbles in material ž Fabricate rapid prototype of stapler ž Integrate staples with stapler ž Functional testing

Ackno knowle ledgme ment nts ž Dr. Tracy Downs ž Professor Tompkins ž Professor Puccinelli ž Professor Murphy ž Polymers Lab

Referenc nces [1] Bladder Cancer. National Cancer Institute . Retrieved October 17, 2011, from http://www.cancer.gov/cancertopics/types/bladder [2] Bladder Cancer. U.S. National Library of Medicine . Retrieved October 17, 2011, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/

Questions ns?