Kinetics PROJECT TEAM 5: VIPUL BHAT, T, RANVIR BHATIA, KATIE - PowerPoint PPT Presentation

Controlled-Release Kinetics PROJECT TEAM 5: VIPUL BHAT, T, RANVIR BHATIA, KATIE CAVANAUGH, ALBERT CHEN, EDWARD GELERNT, MICHAEL HILL-OLIVA, REMY KASSEM, JAI PATEL, RUCHIT PATEL, NHA-UYEN PHAM, JACK XIONG, EITAN ZLATIN TEAM LEADER: DR. CINCOTTA ASSISTANT: SUMA GONDI

Zero Order Kinetics

Diffusion and Fick’s Law 𝐾 = −𝐸 𝜖𝜒 𝜖𝑦

Hypothesis Molecular size inversely proportional with diffusion coefficient Rate inversely proportional to molar mass Size has greater effect than polarity in diffusion 𝑤 1 𝑛 2 = 𝑤 2 𝑛 1

Hansen Solubility Parameters Quantitative model for “like dissolves like” (𝑆𝑏) 2 = 4(𝜀 𝑒2 − 𝜀 𝑒1 ) 2 + (𝜀 𝑞2 − 𝜀 𝑞1 ) 2 + (𝜀 ℎ2 − 𝜀 ℎ1 ) 2

Membranes Polyethylene vinyl acetate Calendar used to make films

Alkanes Ketones Alcohols Pentane (72.15 g/mol) 2-Butanone (72.11 g/mol) 1-Butanol (74.12 g/mol) n-Hexane (86.18 g/mol) 2-Pentanone (86.13 g/mol) 1-Pentanol (88.15 g/mol) Heptane (100.21 g/mol) 2-Hexanone (100.16 g/mol) 1-Hexanol (102.18 g/mol) n-Octane (114.23 g/mol) 2-Heptanone (114.18 g/mol) 1-Heptanol (116.2 g/mol) Solutes • All organic compounds • Varying polarity and size

Experimental Design and Data Collection

Data Analysis Flux (mol/m 2 hr) 𝐸 = −𝐾 × 1 𝜖𝜒 Thickness (m) 𝜖𝑦 Gas concentration (mol/L) 𝐶 log 10 𝑞 = 𝐵 − 𝐷 + 𝑈

MASS OF OCTANE SAMPLE OVER TIME Octane 1 Octane 2 149.5 149 148.5 MASS (G) 148 147.5 147 146.5 TIME (H)

THE EFFECT OF MASS ON DIFFUSION COEFFICIENT Alkanes Ketones Alcohols Linear (Alkanes) Linear (Ketones) Linear (Alcohols) 160 140 DIFFUSION COEFFICIENT 120 100 80 60 40 20 0 70 75 80 85 90 95 100 105 110 115 120 MOLAR MASS (G)

THE EFFECT OF POLARITY ON DIFFUSION COEFFICIENT Alkanes Ketones Alcohols 160 140 DIFFUSION COEFFICIENT 120 100 80 60 40 20 0 72-75G/MOL 86-89G/MOL 100-103G/MOL 114-117G/MOL COMPOUND GROUPING BY MOLAR MASS (G/MOL)

Discussion and Analysis Consistent pseudo-zero-order diffusion achieved Positive correlation between size and diffusion coefficient Positive correlation between polarity and diffusion coefficient Alkanes Ra Ketones Ra Alcohols Ra Pentane 10.1 2-Butanone 5.6 1-Butanol 9.5 n-Hexane 9.7 2-Pentanone 4.7 1-Pentanol 7.8 Heptane 9.3 2-Hexanone 5.3 1-Hexanol 6.6 n-Octane 9.1 2-Heptanone 3.9 1-Heptanol 5.7

DIFFUSION COEFFICIENT AS RA VALUE INCREASES ALKANE RA VALUES 0 2 4 6 8 10 12 ALCOHOL DIFFUSION COEFFICIENT ALKANE DIFFUSION COEFFICIENT 160 25 140 20 120 Alcohols 100 Alkanes 15 Linear (Alkanes) 80 Linear (Alkanes) 10 60 40 5 20 0 0 0 2 4 6 8 10 ALCOHOL RA VALUES

Future Studies Improving data collection and film making methods Studying different membrane makeups Running more trials on pure organic liquids Testing diffusion of larger and smaller organic compounds

Conclusion Observations do not support hypothesis ◦ Polarity has greater influence on diffusion than molecular size Results explained by membrane compatibility

Acknowledgements Team 5 would like to thank… Team 5 would also like to thank… ◦ Dr. David Cincotta, team leader ◦ The Overdeck Family Foundation ◦ Suma Gondi, assistant ◦ AT&T ◦ Dr. Adam Cassano & Dr. Steve Surace, co- ◦ Bayer Healthcare directors ◦ Independent College Fund of New ◦ New Jersey Governor’s School Jersey/Johnson & Johnson ◦ Drew University ◦ NJGSS Alumnae, Parents, and Corporate Matching Funds ◦ Past Team 5s ◦ The State of New Jersey for assisting us with our research and ◦ Board of Overseers, New Jersey Governor’s providing us with an amazing School experience. for their generosity.

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