ISBT WORKING PARTY ON RARE DONORS Canada Canadian Blood Services - PowerPoint PPT Presentation

May 25, 2023 •7 likes •67 views

ISBT WORKING PARTY ON RARE DONORS Canada Canadian Blood Services Have a national Rare Donor Program: Yes Number of Donors in Database: Rare donor code 6260: 1849 donors coded Definition of Rare: A donation/RBC is considered to be rare

ISBT WORKING PARTY ON RARE DONORS Canada – Canadian Blood Services Have a national Rare Donor Program: Yes Number of Donors in Database: Rare donor code ‘6260’: 1849 donors coded Definition of Rare: A donation/RBC is considered to be rare if: • the given phenotype is found in less than approximately 0.02% of the population. The donor can be negative for a high incidence antigen(s) and/or can be negative for an uncommon antigen combination. and • the antibodies associated with the given antigen(s) may cause clinically significant transfusion reactions and/or hemolytic disease of the fetus or newborn (HDFN)
• Number of units in frozen inventory: 1,250 • Approximate number of frozen units thawed annually: 30-100
ISBT WORKING PARTY ON RARE DONORS Canada – Canadian Blood Services Shipping Outcome form used?: not sure Most difficult types to find: - Di (b-) - PP1P k negative
ISBT WORKING PARTY ON RARE DONORS Canada – Canadian Blood Services • Other items of interest: CBS Phenotyping Project • Project to enhance phenotyping – Used to be done at each individual centre – Done by different departments with different methods – Different levels of accessibility to customers • Consolidate testing into the donor testing labs – Standardize testing and service provision – Increase or maintain service to all customers • Goal to increase phenotyped donor base to 35% over 5 years – C, E, c, e, K1, Fya, Fyb, Jka, Jkb, S and s
CBS Phenotyping Project • Whole blood donors with at least 3 donations • O Pos/Neg, A Pos/Neg, and B Neg donors • Increasing R1R1 (DCe/DCe) and R2R2 (DcE/DcE) Rh positive donors • Performing extended antigen screening for Rh negative donors • Confirming once-phenotyped donors on subsequent donation so antigen typing can be on the unit label • Will increase multi-antigen negative rare units 5
Frozen Blood Project • Model has been to have 7 frozen inventories • Based mostly on local needs • Different strategies for choosing which to freeze • Different strategies for updating inventory • Freezing too many of certain types of units, failing to freeze some desirable units • Decided to come up with program to develop national strategy for frozen blood – National inventory based on common strategy 6

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