Innova&on Pla*orm Technology Needs March 2014 Al - PowerPoint PPT Presentation

Innova&on ¡Pla*orm ¡ Technology ¡Needs ¡ March ¡2014 ¡ Al ¡Lauritano ¡ Director, ¡Technology ¡Licensing ¡and ¡Collabora8on ¡ al_lauritano@bd.com ¡ ¡ Glenn ¡Vonk ¡ Director, ¡Advanced ¡Technology ¡ glenn_vonk@bd.com ¡ ¡

Global ¡& ¡Growing ¡ Medical (4.3) Diagnostics (2.6) Biosciences 30,000 Associates in 50 Countries (1.1) 58% Ex-US Revenues (8.1 $B Revenues, 2013) +5.4%

Securing ¡Technology: ¡PLAIID ¡Strategy ¡ • BD Medical (MS) Ø BD Diabetes Care NGOs Ø BD Medical Surgical Systems Partner Ø BD Pharm Systems Corporations • BD Diagnostics (BDD) License Ø BD Diagnostic Systems Foundations Ø BD PreAnalytical Systems .gov Acquire Ø BD Womens Health Start-Ups • BD Biosciences (BDB) Invest Ø BD Adv. Bioprocessing Ø BD Cell Analysis Universities • Information Business Unit (IBU) Incubate • Global Health Angels • BD TBD Develop Incubators Open Innovation Collaborate and Develop Commercialize

BD ¡IncuLink™ ¡Global ¡Accelera&on ¡ ¡ Funding ¡Partner ¡ Angels, ¡VCs, ¡Grant ¡Agency ¡ Corporate ¡ Immediate ¡Benefits: ¡ • Expand ¡Opportunity ¡Pool ¡ • Leverage ¡Risk ¡ • Expand ¡Partner ¡Pool ¡ BD ¡ ¡ Mentoring ¡ & ¡In-­‑kind ¡ (HC, ¡$$$, ¡Services) ¡ Technology ¡Partner ¡ Infrastructure ¡Partner ¡ Inventor, ¡University, ¡ ¡ Accelerators, ¡Incubators ¡ Entrepreneur, ¡NewCo ¡ Clusters ¡

BD ¡Technologies: ¡ ¡Corporate ¡Technology ¡Wants ¡ Information Enabled Medical Devices and Big Data Analytics Technologies that identify, locate and communicate device or patient status to distributed systems. Flexible and scalable architectures with analytics and decision support to enable dynamic care paradigms or satisfy regulatory needs. App human factors and healthcare social networking. Parenteral Delivery Materials, coatings, and adhesives that reduce inflammation or infection to enhance biocompatibility for extended-use parenteral delivery devices. Predictive models that speed preclinical testing decreasing both time & risk of translational clinical studies. Microfluidics Systems for preparing and stabilizing well-characterized plasma, cell and particle populations, nucleic acids, and proteins from whole human blood which minimize risk of infection or contamination. Methods to stabilize different blood components for downstream analytics. Technologies to cost-effectively link these devices to information systems which reliably identify providers and patients. Next Generation Sequencing Specimen preparation and bioinformatic technologies to enable personalized medicine. Corporate V Metagenomic (microbiome) applications, esp. diagnostics. Developing World / Maternal and Neonatal Health Easy to use technologies with significant potential to improve outcomes at an affordable cost.

BD ¡Business ¡Units ¡Technology ¡Wants ¡ Connected Devices Cost-effective, compact, connected, disposable electromechanical devices for acquiring tissues, managing chronic conditions, or administering drugs. Ability to interact with patients, providers, and other assets to minimize infections, needlesticks, exposure hazards, and other adverse events. Devices to enhance patient access and comfort by assisting with routine or complex tasks. Sustainable materials and processes. Specimen Collection and Preservation Cost effective, safe, easy-to-use sample preparation and stabilization. Systems to extract nucleic acids from diverse tissues and or paraffin blocks. Closed, disposable devices to isolate, enrich, or safely preserve rare or single cells from diverse tissues to maximize viability and therapeutic effect. Systems to rapidly separate, mix, and meter human plasma. Automation Automation to improve healthcare efficiency and effectiveness – esp. for nurses, pharmacies, human sample preparation or preservation, and flow cytometry. Diagnostics Probes and dyes offering exceptionally sensitive, robust detection in processed human specimens. Methods for sequencing individual rare cells. Differentiated Point-of-Care diagnostic systems. Non-invasive diagnostics. Analytics Analytics supporting connected BD devices, systems, and their users to improve effectiveness, efficiency, and outcomes. 6