HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE - PowerPoint PPT Presentation

HOW W THE E COVID ID -19 9 OVER VERCOM OMES ES THE E BATTLE TLE ? AN N APPROACH H TO O VIRU IRUS S STRUCTU RUCTURE RE PEDRAM EDRAM AHMADPOOR ADPOOR.MD .MD

S1 :receptor binding S2 : cell membrane fusion ssRNA virus

S1 :receptor binding S2 : cell membrane fusion ssRNA virus

NO NORMAL AL BODY RESPONSE NSE TO VIRAL L INFEC ECTI TIONS ONS

ROTA CMV SARS-COV2 longer-dsRNA Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146

ROTA CMV SARS-COV2 longer-dsRNA Journal of Bacteriology and Virology 2011. Vol. 41, No. 3 p.133 – 146

IFN-g

BLOCKING INTERFERONS  MORE VIRAL REPLICATION UNABLE TO MOUNT ADAPTIVE IMMUNE RESONSE

Functions of interferon class I

DC maturation biochemical pharmacology 72 (2006) 1469 – 1476

biochemical pharmacology 72 (2006) 1469 – 1476

THE OTHER SIDE OF THE COIN

CD40 CD40L CD24+CD38+

CD40 MESSAGE WE NEED A DELICATE AND WELL ADAPTED QUANTITY OF INTERFERON CD40L CD24+CD38+

TGF B/AHR THF-FDC IL IL-21 21 Cold Spring Harb Perspect Biol 2014;6:a016295

TGF B/AHR THE OTHER SIDE OF THE COIN THF-FDC IL IL-21 21 Cold Spring Harb Perspect Biol 2014;6:a016295

SUPPRESSOR OF CHEMOKINE SIGNALING (SOCS) Tolerogenic DCs Blocking nfkb IL 10 secretion

CROSSTALK BETWEEN IL-6 AND INTERFERON GAMMA

SARS-COV-2

BLOCKING THE KEY ELEMENT OF INNATE IMMUNITY AGAINST VIRUS

Mounting an appropriate adaptive response needs a precise and delicate cross talk between DC,T /B cells and interferons / IL-6 …

THANKS NKS FOR OR YOU OUR R ATTENT ENTION ION

SOCS expression