Episode #262 EBM Conscientious Explicit Judicious Best Evidence - PowerPoint PPT Presentation

Oct 31, 2022 •426 likes •661 views

Episode #262 EBM Conscientious Explicit Judicious Best Evidence Individual Patients David Sackett EBM Sackett et al BMJ 1996 Levels of Evidence Systematic Review Appraised Topics Appraised Article RCT Cohort Study Case Report

Episode #262
EBM Conscientious Explicit Judicious Best Evidence Individual Patients David Sackett
EBM Sackett et al BMJ 1996
Levels of Evidence Systematic Review Appraised Topics Appraised Article RCT Cohort Study Case Report Expert Opinion
4 SGEM Xtra: Make it So
EBM is the Worst… "Democracy is the worst form of government except all the others that have been tried." Sir Winston Churchill
EBM has Been Hijacked: Ioannidis JP . J Clin Epi 2016
DR. EVIL Bekelman et al JAMA 2003 Okike et al Injury 2008 Lundh et al Cochrane 2013
Study Designs
ITT vs. PP Analysis Draw your own conclusions
the future is open
SGEM#262: Omadacycline
Guest Skeptic: EM Swami
New York ACEP Scientific Assembly
Case
SGEM#: 13, 131, 156, 164 and 209
O’Riordan et al NEJM 2018 “Omadacycline was noninferior to linezolid for the treatment of acute bacterial skin and skin-structure infections and had a similar safety profile”
4 SGEM Xtra: Make it So
Omadacycline was non-inferior to linezolid
• Funding T a l k N e r d y T o • Selection Bias M e • Non-Inferiority • ITT vs. PP • Why Linezolid?
SGEM Bottom Line Omadacycline is not recommended for the routine use in SSTI
Remember to be skeptical of anything you learn, even if you heard it on the Skeptics’ Guide to Emergency Medicine.

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