1 Infective Endocarditis Guidelines Nadjib Hammoudi Institut de cardiologie hôpital de la Pitié-Salpêtrière European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
2 2015 Guidelines for the Management of Infective Endocarditis Chairperson Co-Chairperson Gilbert Habib Patrizio Lancellotti France Belgium Task Force Members : Manuel J. Antunes (Portugal), Maria Grazia Bongiorni (Italy), Jean-Paul Casalta (France), Francesco Del Zotti (Italy), Raluca Dulgheru (Belgium), Gebrine El Khoury (Belgium), Paola Anna Erba (Italy), Bernard Iung (France), Jose M. Miro (Spain), Barbara J. Mulder (The Netherlands), Edyta Plonska-Gosciniak (Poland), Susanna Price (UK), Jolien Roos-Hesselink (The Netherlands), Ulrika Snygg-Martin (Sweden), Franck Thuny (France), Pilar Tornos Mas (Spain), Isidre Vilacosta (Spain), Jose Luis Zamorano (Spain). www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
3 Classes of recommendations Classes of Suggested wording Definition recommendations to use Classe I Evidence and/or general agreement Is recommmended/ that a given treatment or procedure is is indicated. beneficial, useful, effective. Class II Conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of the given treatment or procedure. Class IIa Weight of evidence/opinion is in favour Should be considered. of usefulness/efficacy. Class IIb Usefulness/efficacy is less well May be considered. established by evidence/opinion. Evidence or general agreement that Is not recommended. Class III the given treatment or procedure is not useful/effective, and in some cases may be harmful. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
4 Levels of evidence Level of Data derived from multiple randomized Evidence A clinical trials or meta-analyses. Data derived from a single randomized Level of clinical trial or large non-randomized Evidence B studies. Consensus of opinion of the experts and/ Level of or small studies, retrospective studies, Evidence C registries. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Infective Endocarditis New guidelines ESC 2015 prevention 1. the “Endocarditis T eam” 2. diagnosis 3. treatment 4. specific situations 5. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Infective Endocarditis New guidelines ESC 2015 prevention 1. the “Endocarditis T eam” 2. diagnosis 3. treatment 4. specific situations 5. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Main principles of prevention in IE 1. Le principe d’antibioprophylaxie est maintenu 2. L’antibioprophylaxie est limitée aux patients à haut risque d’EI avant un geste dentaire à risque élevé . 3.Hygiène bucco-dentaire et suivi par un dentiste +++ 4. Asepsie durant procédures « invasives » www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Cardiac conditions at highest risk of IE Recommendations Class Level Antibiotic prophylaxis should only be considered for patients at highest risk of IE: 1. Patients with a prosthetic valve , including transcatheter valve, or a prosthetic material used for cardiac valve repair. 2. Patients with previous IE . IIa C 3. Patients with congenital heart disease . a. any cyanotic congenital heart disease b. congenital heart disease repaired with prosthetic material whether placed surgically or by percutaneous techniques, up to 6 months after the procedure or lifelong if there remains residual shunt or valvular regurgitation. Antibiotic prophylaxis is not recommended in other forms of III C valvular or congenital heart disease. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Procedures at highest risk of IE Recommendations Class Level A. Dental procedures • Antibiotic prophylaxis should only be considered for dental procedures IIa C requiring manipulation of the gingival or periapical region of the teeth or perforation of the oral mucosa. Antibiotic prophylaxis is not recommended for local anaesthetic injections • in non-infected tissues, treatment of superficial caries, removal of sutures, III C dental X-rays, placement or adjustment of removable prosthodontic or orthodontic appliances or braces, or following the shedding of deciduous teeth or trauma to the lips and oral mucosa. B. Respiratory tract procedures • Antibiotic prophylaxis is not recommended for respiratory tract procedures, III C including bronchoscopy or laryngoscopy, transnasal or endotracheal intubation. C. Gastrointestinal or urogenital procedures or TOE • Antibiotic prophylaxis is not recommended for gastroscopy, colonoscopy, III C cystoscopy, vaginal or caesarean delivery or TOE. D. Skin and soft tissues procedures III C • Antibiotic prophylaxis is not recommended for any procedure. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
10 Prophylaxis for dental procedures at risk Single-dose 30-60 minutes before procedure Situation Antibiotic Adults Children No allergy to Amoxicillin or 2 g orally or i.v. 50 mg/kg orally penicillin or ampicillin Ampicillin a or i.v. Allergy to penicillin Clindamycin 600 mg orally 20 mg/kg orally or ampicillin or i.v. or i.v. a Alternatively, cephalexin 2 g i.v. for adults or 50 mg/kg i.v. for children, cefazolin or ceftriaxone 1 g i.v. for adults or 50 mg/kg i.v. for children. “ Cephalosporins should not be used in patients with anaphylaxis, angio-oedema, or urticaria after intake of penicillin or ampicillin due to cross-sensitivity ”. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
11 Non-specific prevention measures These measures should ideally be applied to the general population and particularly reinforced in high-risk patients. • Strict dental and cutaneous hygiene. Dental follow-up should be performed twice a year in high-risk patients and yearly in the others. • Disinfection of wounds. • Eradication or decrease of chronic bacterial carriage: skin, urine. • Curative antibiotics for any focus of bacterial infection. • No self-medication with antibiotics. • Strict asepsis control measures for any at-risk procedure. • Discourage piercing and tattooing . • Limit the use of infusion catheters and invasive procedure when possible. Favour peripheral over central catheters, and systematic replacement of the peripheral catheter every 3 – 4 days. Strict adherence to care bundles for central and peripheral cannulae should be performed. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Prophylactic measures before cardiac or vascular interventions Recommendations Class Level Pre-operative screening of nasal carriage of Staphylococcus aureus is I A recommended before elective cardiac surgery in order to treat carriers. Peri-operative prophylaxis is recommended before pacemaker or I B implantable cardioverter defibrillator implantation. Elimination of potential sources of dental sepsis is recommended >2 weeks before implantation of a prosthetic valve or other intracardiac I C or intravascular foreign material, except in urgent procedures. Peri-operative antibiotic prophylaxis should be considered in patients undergoing surgical or transcatheter implantation of a prosthetic IIa C valve, intravascular prosthetic, or other foreign material. Systematic local treatment without screening of Staphylococcus aureus is III C not recommended. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
Infective Endocarditis New guidelines ESC 2015 prevention 1. the “Endocarditis T eam” 2. diagnosis 3. treatment 4. specific situations 5. www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
« Team-endocardite » Maladie grave associée à une importante morbi-mortalité • Présentations cliniques multiples , atteinte de plusieurs organes. • Adapter l’attitude au cas / cas • -la présentation clinique -du terrain -du germe -des lésions cardiaques. -des localisations secondaires et / ou des complications systémiques -du risque opératoire - de la faisabilité d’une réparation valvulaire….. >> Nécessité d’une prise en charge multi-disciplinaire en particulier pour les formes compliquées (prothèses, …) www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
The « Endocarditis team » • Characteristics of the reference center 1. Imagerie (échocardiographie, scanner, IRM, médecine nucléaire. 2. Chirurgie cardiaque 3. Plusieurs spécialistes -Cardiologue -Chirurgien cardiaque -Anesthésiste / médecin réanimateur -Infectiologue / microbiologiste -spécialistes en imagerie -autres spécialistes: cardiopathie congénitale, rythmologie, neurologues, neurochirurgiens, neuroradiologie interventionnelle… www.escardio.org European Heart Journal (2015) doi:10.1093/eurheartj/ehv319
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