DR. PARTHA BASU HEAD, DEPARTMENT OF GYNECOLOGIC ONCOLOGY - PowerPoint PPT Presentation

DR. PARTHA BASU HEAD, DEPARTMENT OF GYNECOLOGIC ONCOLOGY CHITTARANJAN NATIONAL CANCER INSTITUTE, KOLKATA, INDIA ROP7

Background  VIA is affordable & feasible test for low & medium resource countries  High rate of false positive tests can offset the cost saving  Triaging options like magnification, cytology etc. have not been successful  HPV DNA detection Hybrid Capture 2 is highly sensitive & reasonably specific  Low cost version (CareHPV) is available ROP7

Objectives & Methods  The study aims to evaluate role of HC2 in triaging the VIA +ve women  Total 21764 women aged 30-60 yrs (mean 38.4 + 6.1 yrs) screened by HC2 & VIA  All VIA +ve women had colposcopy  Punch biopsies obtained if colpo abnormal ROP7

Results NORMAL HPV/ CIN2 CIN3 INV TOTA BX/COLPO ATYPIA/ CA L CIN1 VIA +ve; 756 728 38 8 0 1530 HC2 -ve VIA +ve; 48 54 11 35 18 166 HC2 +ve TOTAL 804 782 49 43 18 1696 • PPV OF VIA FOR CIN3+: 3.6% • PPV OF VIA & HC2 FOR CIN3+: 31.9% ROP7

CONCLUSIONS  Triaging with HC2 reduces referral from 7.8% to 0.8%  Sensitivity to detect CIN3+: 86.9%  Specificity to detect CIN3+: 93.1%  Sample for HC2 can be obtained immediately after VIA ROP7