Dennis Wright, Ph.D. Craig M. Crews, Ph.D. Professor of Medicinal Chemistry Lewis B. Cullman Professor of NPDD Initiative Molecular, Cellular, and Developmental Biology UCONN School of Pharmacy Chemistry, Pharmacology University of Connecticut Center for Molecular Discovery Yale University
PITCH: What?
PITCH: What? An Collaboration between Yale and UCONN to Help Academic Projects Cross the Valley of Death
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics • Increase the number of biotech companies in the State by encouraging faculty entrepreneurism
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics • Increase the number of biotech companies in the State by encouraging faculty entrepreneurism • Employ the latent pool of pharmaceutical talent statewide
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics • Increase the number of biotech companies in the State by encouraging faculty entrepreneurism • Employ the latent pool of pharmaceutical talent statewide • Establish a new paradigm for robust, synergistic research programs between Yale and UCONN, and ultimately to other institutions in the state
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics • Increase the number of biotech companies in the State by encouraging faculty entrepreneurism • Employ the latent pool of pharmaceutical talent statewide • Establish a new paradigm for robust, synergistic research programs between Yale and UCONN, and ultimately to other institutions in the state • Recruit additional venture investment to the state
PITCH: What? • Provide a streamlined translational pathway for researchers to convert their discoveries to new therapeutics • Increase the number of biotech companies in the State by encouraging faculty entrepreneurism • Employ the latent pool of pharmaceutical talent statewide • Establish a new paradigm for robust, synergistic research programs between Yale and UCONN, and ultimately to other institutions in the state • Recruit additional venture investment to the state • Put Connecticut on the map for a new paradigm in drug discovery
PITCH: Who? Craig M. Crews, Ph.D. Dennis Wright, Ph.D. Lewis B. Cullman Professor of Professor of Medicinal Chemistry Molecular, Cellular, and Dev. Biol. NPDD Initiative Chemistry, Pharmacology UCONN School of Pharmacy Center for Molecular Discovery University of Connecticut Yale University
PITCH: Who? Background West Liberty State BS (Chemistry) Ohio University Ph.D. (Chemistry) Stanford Postdoc Training UCONN Joined Faculty in 2006 Experience • New Pathways in Drug Discovery (NPDD) -Co-Founder Promiliad, Inc. • Dennis Wright, Ph.D. -Co-Founder Professor of Medicinal Chemistry NPDD Initiative UCONN School of Pharmacy • Synaptic Dynamics, Inc. University of Connecticut -Co-Founder
PITCH: Who? Background U.Va. BA (Chemistry) Harvard Ph.D. (Biochemistry) Harvard Postdoc Training Yale Joined Faculty in 1995 Experience • Yale Center for Molecular Discovery (YCMD) -Founder/Executive Director Proteolix, Inc. • Craig M. Crews, Ph.D. -Co-Founder Lewis B. Cullman Professor of Molecular, Cellular, and Dev. Biol. Chemistry, Pharmacology • Arvinas, Inc. Center for Molecular Discovery -Founder Yale University -Chief Scientific Officer
PITCH: Where? Y ale Center for Molecular Discovery (YCMD) Y ale West Campus (former Bayer Pharmaceuticals)
PITCH: Where? •Established in 2003 •Occupies building B27 with ~10,000 sf of laboratory and office space •9.5 staff: 7 Ph.D., 2 M.S., 1.5 B.S. Craig M. Crews, Ph.D. •332 Projects in past 5 years with MCDB/Chemistry/Pharmacology investigators from 25 Yale departments •Numerous prominent publications •Providing target identification, small molecule siRNA screening, and medicinal chemistry services •Multiple corporate interactions and start-ups Janie Merkel, Ph.D. Denton Hoyer, Ph.D. Director of Biology Director of Chemistry
PITCH: Where? • 9.5 Full Time Employees – 5 Biology – 3 Chemistry – 1.5 Administrative • Experience in Academia & Industry:
PITCH: Where? Overview of Capabilities • Biology – Assay Development – High Content Imaging – Screening (siRNA and small molecule) • Chemistry – Structure-Activity Modeling – Medicinal Chemistry – Compound Synthesis & Analoging • Assisting with Patent Writing 16
PITCH: Where? YCMD Resources • Liquid Handling & Robotics – 96-, 384-, 1536-well plate compatibility – Sterile or Non-Sterile Environments • Multiple Types of Readouts – At molecule level: Protein-protein, Enzymatic assays – Cell-based, Organism-based assays – High Content Screening - Highly subsidized costs Medicinal, Computational & Synthetic Chemistry • – Synthetic planning & execution/outsourcing – Structure and Ligand-based drug design – Optimization of ligand potency and pharmacokinetics Experience with Multiple Therapeutic Areas • – Oncology, Neurodegenerative, Infectious Diseases, Inflammation, Cardiovascular…
PITCH: Where? Assay for Inhibitors of NPP4 Activity R. A. Albright et al Blood , (2012) 120:4432-4440. X-Ray Structure of Target Proof of Concept Classical High Throughput Screening (Repurposing) Novel Composition of Matter Follow-On Improvement Structure-Based Design Demetrios Braddock, Department of Pathology
PITCH: Where? UCONN Storrs The NPDD is a cross-college initiative dedicated to drug discovery and development with faculty from Pharmaceutical Sciences, Chemistry, MCB and UCH/CICATS New Pathways to Drug Discovery UCONN External Health Partners NPDD: A Drug Discovery Network
UCONN School of Pharmacy The SOP provides an exciting, highly interactive environment for experimental therapeutics with scientists from a broad range of backgrounds united by an interest in drug discovery and development. We are organized into three disciplines… Medicinal Chemistry: expertise in drug design, drug target structure and mechanism of action Pharmacology/Toxicology: expertise in liver toxicology, metabolism and stem cell biology Pharmaceutics: expertise in small molecule formulation, formulation of biologics and drug delivery
Medicinal Chemistry Capabilities Structure-Based Medicinal Chemistry High-Throughput Drug Design Screening Automated handling Drug design/ SAR X-ray crystallography 150K lead library Complex Biomolecular NMR Pharmacological molecule/ parallel Docking Screens (LOPAC) synthesis Virtual Screening Target and Phenotypic Stereoselective Rational Design screens synthesis I n vitro metabolism Physico-chemical property determination
Drug Target Studies at UCONN Health Protein Expression Protein Purification Protein Characterization High Field NMR (800 MHz) Other Biophysical Studies
PITCH: How? External Advisory Board UCONN Evaluation Yale Assay Submission Due: October 1
PITCH: How? Bill LaRochelle, (Sr.Dir, Roche Sequencing Solutions Brian Dixon, (CEO, BioRelix) External Advisory Board UCONN Peter Farina, (SVP, Boehringer Ingelheim) Evaluation Amy Burd, (Exe. Dir. Res Strategy, Leukemia & Lymphoma Society) Yale Henry Showell (Sr. Res Fellow, Pfizer) Assay Live Presentations to the EAB Submission 10am-1:30pm October 30 Yale Center for Molecular Discovery (YCMD) West Haven, CT
PITCH: How? External Advisory Board UCONN Evaluation Yale Pitch Assay Assays Virtual Hit [ in vivo Business SAR/ Assay Development Screened Expansion Testing] Plan Med Chem Submission New Leaf Ventures YCMD Originating UCONN YCMD Lab or Pharm Elm Street CRO UCONN Ventures Protein Production OrbiMed Ventures Core Canaan Partners Ventures Other VCs/Pharma Venture Funds? Out-license?
Three Year Goals 36 Assays 30 Assays 24 Virtual Hit 12 SAR/ # Assays 8 Business 8 Pitches Developed Screened Expansions Med Chem Submitted? Plans
PITCH: When? Deadlines: Submission of Slidedeck PITCH Application: October 1
PITCH: When? Deadlines: Submission of Slidedeck PITCH Application: October 1 Faculty Presentation to External Advisory Board: October 30 th (at the YCMD)
PITCH: When? Deadlines: Submission of Slidedeck PITCH Application: October 1 Faculty Presentation to External Advisory Board: October 30 th (at the YCMD) Notification of Awards: Mid November
Project Title Investigators To see TIPS and FAQS for each slide, please look at this template in Notes view. 30
Two Year Goal Statement Your two year goal will frame the following assessment. 31
Project Team • Brief background for team members and their roles on this project. • Include relevant past experience, if any. • Identify unfilled roles needed. 32
Scientific Background and Opportunity Briefly, introduce background science. What is the problem worth solving? What is your solution? Why is it novel? 33
Recommend
More recommend
