Data analysis in (infra)Structure and project evaluation genetic - PDF document

Areas of expertise Data analysis in • (infra)Structure and project evaluation genetic epi and advise • Methodological advise (study design, Yurii Aulchenko Independent researcher & consultant planning of analyses, methods, yurii [dot] aulchenko [at] gmail [dot] com software) • Teaching and training • Methods, algorithms and software Wednesday, November 23, 11 Wednesday, November 23, 11 Data generation Wednesday, November 23, 11 Wednesday, November 23, 11 Data generation Data generation Analysis Analysis Meta-analysis & replication Wednesday, November 23, 11 Wednesday, November 23, 11

Aim: Prepare (phenotypic & genotypic) data for genetic Data generation Data generation epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11

Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11

Aim: Prepare (phenotypic & Aim: Prepare (phenotypic & genotypic) data for genetic genotypic) data for genetic Data generation Data generation epidemiologic analysis epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Prepare (phenotypic & Aim: establish relation of genotypic) data for genetic phenotype to genotype Data generation Data generation epidemiologic analysis Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: establish relation of Aim: establish relation of phenotype to genotype phenotype to genotype Data generation Data generation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11

Aim: establish relation of Aim: establish relation of phenotype to genotype phenotype to genotype Data generation Data generation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: establish relation of Aim: establish relation of phenotype to genotype phenotype to genotype Data generation Data generation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Provide initial insight Aim: establish relation of into biological mechanisms phenotype to genotype Data generation Data generation underlying established genotype-phenotype relation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Functional genomics Functional genomics Wednesday, November 23, 11 Wednesday, November 23, 11

Aim: Provide initial insight Aim: Provide initial insight into biological mechanisms into biological mechanisms Data generation Data generation underlying established underlying established genotype-phenotype relation genotype-phenotype relation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Humoral Cholesterol Humoral Cholesterol Lipid transform Regulation of immune Response to metabolic Lipid transform Regulation of immune Response to metabolic hydrolase activity response nutrient process hydrolase activity response nutrient process Regulation of Regulation of protein transport protein transport Response Sterol Response Sterol to nutrient metabolic to nutrient metabolic levels process levels process Steroid Steroid metabolic metabolic process process Response to Response to extracellular extracellular stimulus stimulus Functional genomics Functional genomics TC TC Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Provide initial insight Aim: Provide initial insight into biological mechanisms into biological mechanisms Data generation Data generation underlying established underlying established genotype-phenotype relation genotype-phenotype relation Humoral Cholesterol Regulation of Lipid transform immune Response to metabolic Analysis Analysis hydrolase activity response nutrient process Regulation of protein transport Response Sterol to nutrient metabolic levels process Steroid metabolic process Meta-analysis & replication Meta-analysis & replication Response to Humoral Cholesterol Regulation of Lipid transform hydrolase activity immune Response to metabolic extracellular response nutrient process Regulation of protein transport stimulus Response Sterol to nutrient metabolic levels process Steroid metabolic process Response to extracellular stimulus Functional genomics Functional genomics TC TC Wednesday, November 23, 11 Wednesday, November 23, 11 Aim: Provide initial insight Aim: Provide initial insight into biological mechanisms into biological mechanisms Data generation Data generation underlying established underlying established genotype-phenotype relation genotype-phenotype relation Analysis Analysis Meta-analysis & replication Meta-analysis & replication Humoral Cholesterol Humoral Cholesterol Lipid transform Regulation of immune Response to metabolic Lipid transform Regulation of immune Response to metabolic hydrolase activity response nutrient process hydrolase activity response nutrient process Regulation of Regulation of protein transport protein transport Response Sterol Response Sterol to nutrient metabolic to nutrient metabolic levels process levels process Steroid Steroid metabolic metabolic process process Response to Response to extracellular extracellular stimulus stimulus Functional genomics Functional genomics TC TC Wednesday, November 23, 11 Wednesday, November 23, 11