Cryolipolysis, RadioCavitation, Multipolar RF and Lipomassage
Biotec Italia: enhancing people skin since 1993 • Established in 1993 • Manufacturing and distributing machines, cosmeceuticals to aestheticians and doctors in over 50 Countries • Cooperating with research centers, universities and pharmaceutical companies in Italy and UK • 2 product lines Renlive and Rejuve , mesotherapic cocktails, hyaluronic acid fillers and a number of machines for aesthetic and medical use. • Machines for aesthetic use are all CE marked • Machines for medical use have a medical CE • Medical ISO 13485 standards
State of the art technology We DO NOT sell machines We sell PLATFORMS Combined technologies in one single unit Better results Save money space!
Complete aesthetic solution For facial and body procedures Cryolipolysis Radiocavitaion Multipolar RF Lipomassage CoaxMed offers the most advanced body and facial procedures by Integrated Intelligent technology. The modular system provides 4 major technologies Cryolipolysis , Radiocavitation , Multi-polar RF and Lipomassage ,to complete effective non-invasive facial and body procedures. 2
Convenient User Interface [ Face Contour MODE ] [ Choose treatment by skin condition or by procedure ] [ CoolShape MODE ] [ Lipomassage MODE ] 22
Handpieces Skin Tite RF Shape Face Fractional Needles RF + Vacuum Mono + Bipolar RF + Vacuum + Cryo CoolShape Cryo + Vacuum, + Radiofrequency 3-Polar RF DuoShape Multipolar Rf + Vacuum + Cryo Radiofrequency + Cavitation 4
What is Cryolipolysis? Cryolipolysis refers to a novel non-invasive technology using cold exposure to selectively and gradually lead to the reduction of subcutaneous fat. When fat cells are exposed to precise cooling, they trigger a process of natural removal that gradually reduces the thickness of the fat layer. The fat cells in the treated area are gradually eliminatedthrough the normal metabolic process of unwanted fat elimination. 5
How Cryolipolysis works? Step 1. fat area Emit heat-cool energy to target. Step 2. T arget fat area with maintaining cool-energy extraction rate. Step 3. Fat cells reach a biological death slowly. Step 4. The fatty cells in the treated area are eliminated through the body ’ s natural metabolism process. 6
How CoolShape handpiece works? STEP1. Start STEP2. Immediate STEP3. 30 days STEP4. 90 days Heat-Cryo energy Cryo-reaction Metabolism process Eliminated cells Apply Coolshape The fat cells in the target The fat cells are eliminated. Following the treatment, applicator at the target area, area begin responding to fat cells reach an biological Start treatment to reach cryo-crystallization. death and removed by a target temperature. metabolism process. 7
CoolShape Integrated T echnology by Cryo, V acuum and RF E n d Lipolysis P o i n t : Powerful Cryolipolysis system - Fouror eight powerful cooling elements fitted in to the handpiece. - Automatically control the cooling temperature. - maximum -10 ° C V ariable vacuum function - Controllable vacuum level : step 10(low) to step 60(high) Vacuum RF Bipolar Radiofrequency 11
Handpiece layout CoolShape 247mm 148mm 12
Clinical Method Skin before treatment Clinical evaluation of the patient; Selection of the area to be treated (dermographic pen); A protective membrane is placed on the skin; The area to be treated is sucked into the handpiece; The treatment starts with the preheat cycle and then the area is gradually brought to - 10 ° C and a cycle of 60 minutes begins Skin after treatment 8
TreatedAreas by CoolShape 40%� 35%� 26%� 30%� 20%� 10%� 10%� 7%� 10%� 4%� 5%� 3%� 0%� � � � � � � � � n s k k s s k t k e m s c n c e a n a o e m u r e a B n r A r o l T k u B F d / B s b h A g i h T Love Handles Male patients with pseudo gynecomastia asked for a treatment in the breast area 8
Ultrasound Results by CoolShape Fat layer evaluation An ultrasaund device has been used to assess the thickness of the fat layer before the treatment and after 30 and 60 days Picture of the treated area before the treatment and after 30 and 60 days Courtesy of Ciro Borriello MD 8
Ultrasound Results by CoolShape ( F / 31, Abdomen, 2 session with 4 weeks interval) 0.92 cm 2.06 cm 14:55:09 July 30, 2013 17:55:20 May 20, 2013 before treatment 8 weeks after treatment ( 4weeks after second treatment ) Note the 1.14cm change in subcutaneous fat thickness 8
Ultrasound Results by CoolShape ( F / 39, Abdomen, 2 session with 4 weeks interval) 0.99 cm 2.16 cm March 08, 2013 10:45:33 May 22, 2013 16:45:22 before treatment 8 weeks after treatment ( 4weeks after second treatment ) Note the 1.17 cm change in subcutaneous fat thickness 9
Ultrasound Results by CoolShape ( M / 26, Abdomen, 2 session with 4 weeks interval) 0.88 cm 1.52 cm This delivered Sep 08, 2013 11:25:20 Nov 30, 2013 15:30:35 before treatment 8 weeks after treatment ( 4weeks after second treatment ) Note the 0.64cm change in subcutaneous fat thickness 10
Clinical Results by CoolShape Patient M.A. Female, 27 years before treatment 6 weeks after treatment ( 2weeks after second treatment ) 8
Clinical Results by CoolShape Patient F.M. Male, 21 years before treatment 6 weeks after treatment ( 2weeks after second treatment ) 8
Clinical Results by CoolShape Patient G.C. Male, 25 years before treatment 6 weeks after treatment ( 2weeks after second treatment ) 8
Clinical Results by CoolShape Patient R.C. Female, 35 years before treatment before treatment 8 weeks after treatment ( 4weeks after second treatment ) 8
Histological Analysis by CoolShape During our experience, we performed some treatments on surgical patients one month before an abdominoplasty after surgery, the fat excess piece removed was submitted to a private lab for histological analysis. Histological sections were stained with hematoxylin and eosin and evaluated microscopically to assess the level of fat damage and any damage to the dermis or epidermis. The analysis showed a widespread phagocitosys of fat cells by macrophages 8
CoolShape Delivers optimized heat-cool energy for local reduction of fat cells a n d reshape body contours. The exposure to cooling causes fat cell death without damage to other tissue area or skin surface. Maintain the stable target temperature during treatment. Additionally V acuum and RF cycle effectively enhance the treatment result and skin elasticity. The fatty cells in the treated area areeliminated through the body ’ s natural metabolic process . Fatty layer reduction show persistent results at least 6~8months after the treatment. 13
Duoshape Performance (Cavitation + Radiofrequancy) DuoShape (capacitative monopolar radiofrequency + Low Frequency Ultrasoung), has the aim of producing heat and activating the heat shock proteins and to generate nonthermal selective focused ultrasound to produce localized mechanical motion within fats tissues and cells for the purpose of producing mechanical cellular membrane disruption. Low Frequency Ultrasoung aims also to sonophoresis mesotherapy which allows specific substances to penetrate the cell cytoplasm in order to activate the metabolism of fats in any area of the body where there is an accumulation of fat and in all types of tissues, including those that display signs of flaccidity. Cavitation Effect [Data: Nature, 2005] 14
Cavitation Performance Cavitation consists in the formation of gas bubbles in a liquid Bubbles form during a negative pressure phase They get bigger and bigger during this phase The great pressure exerted on the just expanded bubble, compress the bubble, thus leading to a great increase on the gas temperature in them contained MONITORING WITH ELECTRONIC MICROSCOPE OF CA VIT A TION Before Cavitation 2 min. later 5 min. later 10 min. later 15
DuoShape Enhances deep fat removal effect Fat reduction Powerful Ultra-cavitation performance Effective 28 KHz Ultrasound frequency Effective Monopolar Radiofrequency 600 Khz Water cooling for ultrasound stable emission 16
3-Polar RFPerformance 3-Polar RF technology painlessly delivers focused and optimal RF energy to the skin surface and to subcutaneous fat layers. Controlled energy is delivered via 3 electrodes, centered between them, and limited only to the treatment area. This delivered RF energy that improves result in the treated focal area. Vacuum suction can be combined to optimized RF delivery 3-Polar RFT reatment Process 19
3-Polar Shape 3-Polar RF thermal energy Tightening, Lymph drainage Multi-polar RF Thermal energy Applied temperature sensor technology Synergetic combination of multi-polar RF, Cryo and Vacuum suction Maximize the effect by optimum RF frequency Stimulate blood circulation Effect of skin tightening and lymph drainage 20
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