=> Could only be submi0ed once during the first year of the COST - PowerPoint PPT Presentation

=> Could only be submi0ed once during the first year of the COST ac<on

Swiss COST Project Call Renal diffusion MRI in chronic kidney disease: a mul>- centric approach JP Vallée (Geneva University Hospital) H Thoeny (Fribourg Canton Hospital) Collaborators Pr Sophie De Seigneux, Dr Lena Berchtold, Nephrology clinics, HUG, Geneva Dr Lindsey Crowe, Iris Friedli, Radiology clinics, HUG, Geneva Dr Sebas<ano Barbieri, Radiology clinics, Inselspital, Bern Pr Bruno Vogt, Nephrology clinics, Inselspital, Bern Pr Peter Vermathen, Radiology clinics, Inselspital, Bern

Hypotheses Diffusion MRI has the poten<al to robustly iden<fy CKD pa<ents with different levels of fibrosis. As a second hypothesis, a combina<on of DW-MRI with serum or urinary biomarkers could further improve the assessment of fibrosis.

Study design ⇒ mul>-centric cross-sec>onal study (Geneva and Bern) ⇒ Nb = 300 pa>ents in 4 years Pa<ents will be examined by MRI within 24 h of their renal biopsy. This data will be analyzed according to the subprojects, including improved DW-MRI post-processing (IVIM vs. ADC), DW-MRI reproducibility and automated segmenta<on of the renal parenchyma. The sensibility, specificity and accuracy of the ΔADC including a combina<on with other biomarkers to predict a threshold of 40% of fibrosis or more will be calculated. Prognos<c value of these biomarkers will also be calculated in our cohort. We will perform a reproducibility study on the Geneva and Bern sites as well as other European centers in the context of the COST ac<on. These data will be used within the COST networks to define standards for DW-MRI protocols. => 320’000 CHF for 4 years (250’000 euros) => Opportunity for collabora<on within the COST ac<on on CKD