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Coming Clean About Norovirus: How to Dodge the Spread NEHA-BIA Webinar Lee-Ann Jaykus, Ph.D. William Neal Reynolds Professor Department of Food, Bioprocessing and Nutrition NC State University Norovirus Structure and Classification Small


  1. Coming Clean About Norovirus: How to Dodge the Spread NEHA-BIA Webinar Lee-Ann Jaykus, Ph.D. William Neal Reynolds Professor Department of Food, Bioprocessing and Nutrition NC State University

  2. Norovirus Structure and Classification  Small (35 nm), non-enveloped, SS (+) RNA  Member of Caliciviridae family, genus Norovirus  Species specific and tissue tropic  Role of GII.4 epidemic strain Donaldson, et. al. 2010. Nat Rev Microbiol. 8(3):231-41.

  3. Epidemiological Significance and Costs » Leading cause of acute gastroenteritis worldwide (Lopman et al., 2016) » Approx. 20 million cases annually in US • 1 in every 15 persons, 5-7 times in a lifetime • 75% person-to-person transmission • 15-25% foodborne transmission » High prevalence, low mortality » Overall cost of norovirus = $64.5B globally ⋄ Cost of a single foodborne outbreak = $3911 to $2.05M (Bartsch et al., 2018) ⋄ Cost of individual case = $888-$1766 (Scharf et al., 2015)

  4. Role of Retail and Food Service » Leading cause of foodborne illness in the US (5.5 million cases per year) • Infected food handlers cause about 70% of reported norovirus outbreaks from contaminated food (when a cause is found) • In over half of these cases the workers had bare hand contact with ready-to-eat foods (Hall et al., 2014) » Based on analysis of CDC NORS data (Hall et. al., 2012) • 64% Restaurants • 17% Catering/banquet facilities • 13% Other • 4% Homes • 2% Schools, daycare, and healthcare facilities

  5. Cultivation and Surrogates --Human norovirus cannot be readily cultivated in vitro !!!!! --No small animal model pH stability for 30 min incubation --Limits ability to study 8 --Surrogates for infectivity (study, MNV FCV infectivity reduction ( log PFU/ml) regulatory approval) 6 --Surrogates do not always behave the same as human norovirus 4 --This complicates matters 2 0 2 3 4 5 6 7 8 9 10 pH

  6. Infectivity » Low infectious dose (~100 viral particles?) (Atmar et al., 2008) » Copious shedding (10 5 – 10 11 genome copies/g feces) » Prolonged and even asymptomatic shedding

  7. Hand Contamination » Hand carriage on experimentally- infected individuals (Liu et al., 2013) • While more common with those with symptoms, there was a case of hand contamination in an uninfected person who had been in the room of someone who was infected.

  8. Virus Persistence  Surfaces  Room temperature: Days/ weeks  Foods and water  Refrigeration: Weeks/months/ years  Freezing: Months/ years  Transferability  Variable (0.1%->90%)  Depends on moisture, surfaces, pressure, virus  Sequential (10X)  Environmental contamination  Outbreaks  Endemic  Virus concentrations  Relative importance of hands, surface, air to foodborne transmission (attribution)

  9. Surface Disinfection  Formulation matters  Efficacy impacted by concentration, contact time, soil  Active compounds (ingredients)  Chlorine, 1,000-5,000 ppm (+)  Benzalkonium chloride chloride (-)  Phenols  Hypochorous acid, up to 250 ppm  Silver dihydrogen citrate  Activated hydrogen peroxide  Emerging technologies  Soft surfaces?  Label claim issues-surrogates

  10. Hand Sanitizers  Formulation matters  Product type [actives]  Alcohol [70-90%, ethanol, isopropanol, n-propanol] (-)  Benzalkonium chloride chloride (-)  Triclosan (-)  Emerging actives  Product application (volume and time)  Validation/methodological issues  Regulatory/licensing/use issues  Never a substitute for hand-washing  Could be a useful addition … ..

  11. Is Human Norovirus a ‘Perfect’ Pathogen?  The perfect pathogen?  Highly infectious  Moderately virulent  Rapidly and efficiently spread  Rapid evolution, limited immunity  Environmentally persistent  Resistant to many sanitizers, disinfectants, and processing technologies  Difficult to detect and control  DOES NOT GROW OUTSIDE HOST

  12. Sandra M. Long, REHS/RS Environmental Health Manager Town of Addison, TX

  13. Regulatory/Health • Norovirus - description • Written clean up procedures • Foodservice employee protocols o Exclusion o Restriction o reporting • Health Dept investigations

  14. What is Norovirus? • Various Names • On-set time Symptoms of norovirus illness usually begin about 24 to 48 hours after ingestion of the virus, but they can appear as early as 12 hours after exposure.

  15. Wh Who o gets gets Noro orovirus virus? • Anyone can become infected with these viruses. There are many different strains of norovirus. • Because of these differences in genetic factors, some people are more likely to become infected and develop more severe illness than others.

  16. How it Spreads Eating food or drinking liquids that are contaminated with norovirus; o Touching surfaces or objects contaminated with norovirus, and then o placing their hand in their mouth; Direct contact with another person who is infected and showing o symptoms Persons working in day-care centers or nursing homes should pay special o attention to children or residents who have norovirus illness

  17. Where is it?

  18. Cont ontagious agious? • People infected with norovirus are contagious from the moment they begin feeling ill to at least 3 days after recovery. Some people may be contagious for as long as 2 weeks after recovery. • It is particularly important for people to use good handwashing and other hygienic practices after they have recently recovered from norovirus illness .

  19. Prevention ention Frequently wash your • hands Wash fruits and • vegetables, and steam oysters before eating them. Clean and disinfect • contaminated surfaces Remove and wash • clothing or linens that may be contaminated. Flush or discard any • vomitus and/or stool

  20. Regulatory Protocols • Locations: Food Establishment, o Care facility, o Public areas o • Personal Protective Equipment • Environmental Cleaning • Staff Policies • Visitor Policies • Health Dept Investigations

  21. What Can I Use? • https://www.epa.gov/pesticide-registration/list-g- epas-registered-antimicrobial-products-effective- against-norovirus

  22. What Can I Use? • 6836-77 LONZA FORMULATION S-18 • 6836-78 LONZA FORMULATION R-82 • 11346-2 Clorox HL • 11346-3 Clorox HW • 11346-4 Clorox QS • 11346-6 Clorox HS • 34810-36 CLEAN-CIDE WIPES • 71654-7 VIRKON • 71847-2 KLOR-KLEEN • 71847-6 KLORSEPT • 71847-7 KLORKLEEN 2

  23. Posters

  24. Posters

  25. Traci Slowinski, REHS Sr. Manager, Quality Assurance & Food Safety Brinker International Dallas, TX

  26. Retail/Food Service Programs • Employee Illness & Reporting Policy • Emetic Event (vomit & diarrhea) Cleanup Procedures • Norovirus Disinfection Protocol • Internal/External FBI Monitoring & Reporting • FBI Outbreak Investigation & Response Prevention = Protecting Ourselves & Our Brands

  27. Employee Illness & Reporting Policy Norovirus & Restaurant • Reporting & Exclusion Outbreaks: Policy • Condition Reporting #1 Cause of Foodborne Illness Agreement • Policy Acknowledgement 64% Outbreaks attributed to Restaurants • Medical Referral Form 70% Caused by Infected Food Workers Source: CDC Vital Signs June 2014

  28. Emetic Event (vomit & diarrhea) Cleanup Procedures • Personal Protective Equipment • Clean Up Materials • Disinfectant Product • Disposal • Personal Hygiene (post cleanup)

  29. Norovirus Disinfection Protocol  When: Spike in Norovirus in community  Suspect introduction from employee or guest  Other outbreak/illness spread concerns  During peak Norovirus season   Where: High guest touch points  Known V&D locations   How: Utilize proper disinfectant  Ensure proper dwell time  Determine additional steps for food contact  surfaces

  30. Internal/External FBI Monitoring & Reporting Reporting Sources Monitoring Tools  Guest  Spreadsheets (pivot tables, Relations/Engagement graphs)  Operations/Risk  Dashboards (tableau, heat maps)  Social Media Streams  Summary Reports (Word,  Iwaspoinsoned.com Excel)

  31. FBI Outbreak Investigation & Response  Monitor reporting systems to identify any emerging situations  Work with health department on any investigations  Review food safety programs and practices to identify gaps or causes  Initiate response plan – disinfection protocol, employee illness monitoring, guest FBI monitoring  Prepare for media and guest response

  32. CONTACT INFORMATION Lee-Ann Jaycus, Ph.D. lajaykus@ncsu.edu Sandra M. Long, REHS/RS slong@addisontx.gov Traci Slowinski, REHS Traci.Slowinski@Brinker.com www.nehabia.org

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