Twitter: @BostonUResearch | #researchontap INDUSTRY ON TAP Collaborations Advancing Research January 30, 2020 bu.edu/research/events
@BostonUResearch | #researchontap The Art of Industry: Two Strategies for Working with Boston University Slideshow Title Goes Here Industry Mark W. Grinstaff Boston University Departments of Biomedical Engineering, Chemistry, and Medicine Division of Material Science and Engineering mgrin@bu.edu; http://people.bu.edu/mgrin 2
@BostonUResearch | #researchontap Strategy 1 Boston University Slideshow Title Goes Here Solution or partial solution to a societal problem identified Start-up formed Stop further research in the lab Challenges 3
@BostonUResearch | #researchontap Strategy 2 Partial solution to a societal problem identified Boston University Slideshow Title Goes Here Unified goals Continue research in the lab Joint meetings and publications Contracts and stipulations Rights to technology 4
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here The Red Hat and Honda Research Institute Collaboratories at Boston University Azer Bestavros Warren Distinguished Professor of Computer Science (Founding Director of the Hariri Institute for Computing) Associate Provost for Computing & Data Sciences 5
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here 6
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here 7
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Collaboration with Eisai, Inc. Targeting the β -catenin/CBP Axis for the Treatment of Head and Neck Cancer Maria A. Kukuruzinska, PhD Professor and Interim Chair, Department of Translational Dental Medicine Associate Dean for Research, School of Dental Medicine Director, Head and Neck Cancer Program Collaborative Multidisciplinary Team Science: epithelial and stromal cancer biology, animal models, genomics/epigenomics, molecular biochemistry, in silico analyses
I. Interest to Eisai, Inc.: • Collaborative team science, Mechanism of Action, computational expertise, preclinical models; • Extensive accumulated basic science and preclinical data (~ 8 published studies from our team: Sengupta et al., (2010) J Biol Chem; Sengupta, et al, (2013) J Cell Sci;Bais, et al., (2015) Oral Oncology; Hiemer, et al. (2015) Mol Can Res; Vargas, et al., (2016) PLoS Comp Biol; Kartha, et al., (2018) Genome Medicine; Alamoud and Kukuruzinska, (2018) Molecular Determinants of Head and Neck Cancer;) • Established collaboration with a medical head and neck cancer oncologist at MGH with a strong clinical collaboration with Eisai, Inc. on Anaplastic Thyroid Cancer; • Routine meetings with Eisai, Inc. leadership scientific and business oncology team at AACR, ASCO, and local meetings; CDA, 2016; SRA, June, 2019. II. Current Eisai-sponsored Program - the arrangement with Eisai, Inc.: • SRA budget: supports partial PI and co-Inv salaries, supplies, animal studies, PhD student research; • Collaborative, monthly WebEx conferences with Japan, UK and US; • Problems addressed in an expedient and productive manner; • Eisai leadership/investigators highly supportive of publication initiatives, very quick turn around with reviews: 5 abstracts submitted to AACR Annual Meeting 2020 1 manuscript submitted (Mol Omics), 2 in preparation III. Benefits: • To Eisai, Inc. : Program addresses need to know (tumor heterogeneity, characterization of subpopulations of metastatic cells, MOA of E7386 including epigenetics, posttranslational modifications, changes in network connectivities; supports moving E7386 to clinical trials with human patients; • To PI and team : Discovery science, generation of extensive data on basic and translational levels for generation of new hypotheses, future research grant submissions, publications and new program developments.
@BostonUResearch | #researchontap Targeting the β -catenin/CBP Axis for the Treatment of Head and Neck Cancer Boston University Slideshow Title Goes Here
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here High Throughput Therapeutics at High Containment Robert Davey Professor NEIDL, Microbiology, BUMC 11
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Doctors without borders Infection % High density anti-viral screening, fast, at BSL4 Drug concentration 12
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here animal testing human V mouse C immunize evaluate mAbs Lessons learnt: • 1) Lawyering, 2) confidentiality, 3) need strong admin 13 support, 4) long time with potentially few publications
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Industry Engagement through the Photonics Center Thomas Bifano Director BU Photonics Center 14
@BostonUResearch | #researchontap Business innovation and industry engagement at BUPC The Center manages a 6000sf Business Innovation Center , and supports activities related to entrepreneurship and commercialization. Boston University Slideshow Title Goes Here • ~70 Companies • Raised > $650MM • Multiple exits, 1 IPO • Created > 1000 jobs New theme : Include big companies with Core element of BUPC strategic alignment to Mission: Translate enabling BUPC (AD, Thor). research discoveries into NxTec Continue to support BU useful prototypes. and photonic startups. The Center regularly leads industry-university collaborations for R&D (I/ UCRC, ERC, GOALI, etc). Recruit fee paying members to ERC innovation ecosystem. Support translational activities and development projects with industry funds ~$250k/yr.
@BostonUResearch | #researchontap Example: CELL-MET ERC CELL-MET Value chain Engineering Heart Tissue: $40MM 10Yrs Organ-on-Chip Therapeutic Patient Monitor Engr. Systems Nanostructures Bio-materials Cells Tissue Engr. Tox/Efficacy Tissue Patches & Diagnostics Support Boston University Slideshow Title Goes Here
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Commercializing an Immunoassay for an Autoimmune Kidney Disease David J. Salant Professor Department of Medicine, BUSM 17
@BostonUResearch | #researchontap The Discovery Membranous Nephropathy • A relatively common autoimmune kidney disease Boston University Slideshow Title Goes Here • Autoantibodies damage the filtering unit • Proteins leak into the urine • Total body swelling • May cause kidney failure • Kidney biopsy required for diagnosis 18
Commercialization Intellectual property application filed prior to MS submission – Priority 2008-07-18 • Filed 2009-07-20 • Published 2010-01-21 Soon after publication approach by major healthcare diagnostic company • Several months unsatisfactory negotiation - expectations • We would have to produce and provide reagents for assay • Uncertain experience with developing immunoassays • Know-how from our program for 3-5 years • Unfavorable milestones EuroImmun approached us Well-established in developing and marketing diagnostic immunoassays Had developed IFA (BioChip) using rhPLA2R and tested MN patient samples Licensed from BMC and Le Centre National De La Recherche Scientifique 84% 79% 68% Summary of data rPLA2R+ rPLA2R- submitted to FDA FDA approval July 2014 Positive Negative MN serum MN Ab rhPLA 2 R 19 Primary MN Secondary MN Other GN
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here The Mass Open Cloud Orran Krieger Professor Electrical and Computer Engineering 20
It’s real @BostonUResearch | #researchontap USAF MIT LL Red Hat Two Sigma Boston University Slideshow Title Goes Here Lenovo Dell Intel Cisco Elastic Secure Infrastructure IBM Harvard IQSS 2500 cores, 400 Power9 Cores, 40 GPUs, 1+ PB 5 TB RAM ~40TB RAM • Block and S3 Object storage POWER9 AC922 servers • Bare Metal Physical machines • 5.6x CPU to GPU BW vs standard Intel via NVLink 2.0 • IaaS – VM, Volume • 40 NVIDIA Tesla V100 GPUs delivering up to 5,000 Teraflops for Deep Learning • Spark, Hadoop • All major open source Deep Learning Frameworks • OpenShift: enterprise deployment of Kubernetes container platform: • PowerAI Distributed Deep Learning enables AI across multiple servers 20+ PB • Built in CI, Monitoring, Load Balancing,
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Users NERC MOC OIL OCT Core Partners Cloud Research
@BostonUResearch | #researchontap Boston University Slideshow Title Goes Here Industry and Academia Partnership Process Laboratory for Human Neurobiology Dr. Kevin “Kip” Thomas Assistant Professor Anatomy and Neurobiology, School of Medicine 23
Recommend
More recommend
