clear genetic and epidemiological evidence for ldl c as a
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Clear genetic and epidemiological evidence for LDL-C as a risk factor Meta-analysis of 312,321 participants: long-term exposure to lower LDL-C was associated with 54.5% reduction in risk of CHD for each 1 mmol/L (38.7 mg/dL) lower LDL-C 1


  1. Clear genetic and epidemiological evidence for LDL-C as a risk factor Meta-analysis of 312,321 participants: long-term exposure to lower LDL-C was associated with 54.5% reduction in risk of CHD for each 1 mmol/L (38.7 mg/dL) lower LDL-C 1 Mendelian randomization analysis 2 [To convert, 100 mg/dL=2.59 mmol/L]. CHD, coronary heart disease; LDL-C, low-density lipoprotein cholesterol; LDLR, low-density lipoprotein receptor; LLT, lipid- lowering therapy; PCSK9, proprotein convertase subtilisin/kexin type 9; SE, standard error. 1. Ference BA, et al. J Am Coll Cardiol 2012;60:2631 – 9. 2. Ference BA, et al. J Am Coll Cardiol 2015;65:1552 – 61.

  2. Recall of mass-media messages generally was high, but mass- media campaigns had very little impact on physical activity behavior. Interventions using print and/or telephone were effective in changing behavior in the short term. Studies in which there were more contacts and interventions tailored to the target audience were most effective. A key issue for research on media-based physical activity interventions is reaching socially disadvantaged groups for whom access, particularly to new forms of communication technology, may be limited. (Am J Prev Med 1998;15(4):362 – 378)

  3. Clin Hypertens (Greenwich). 2015;17:644 – 650. Widespread and well-documented difficulties in the ability to take an accurate and reproducible BP measurement. Low-resource-driven cost decisions have contributed to a predominance of unreliably calibrated aneroid manual BP measurement devices

  4. Task-shifting strategy : defined as the rational distribution of primary care duties from physicians to non-physician healthcare providers BMJ Open 2014;4: e005983. doi:10.1136/ bmjopen-2014-005983

  5. BMJ Open 2014;4: e005983. doi:10.1136/ bmjopen-2014-005983

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