CIS II: Project 15 MOUSE OPTICAL PROPERTIES SUMMARY UPDATED: - PowerPoint PPT Presentation

CIS II: Project 15 MOUSE OPTICAL PROPERTIES SUMMARY UPDATED: 4.13.2016

Notes and Conventions Cow: Green Human: Blue Mouse: Red Pig: Black Rat: Purple Using the following parameters for Alexandrakis calculations: Prahl S A 2001 http://omlc.ogi.edu/spectra/index.html (Oregon Medical Laser Clinic) http://omlc.org/spectra/hemoglobin/summary.html lambda(nm) HbO2 molar extinction(1/cm/M) Hb molar extinction(1/cm/M) HbO2 absorption (1/cm) Hb absorption (1/cm) 590 14400.8 28324.4 77.12800558 151.7002167 610 1506 9443.6 8.065855814 50.57816465 630 610 5148.8 3.267046512 27.57601488 650 368 3750.12 1.970939535 20.08494502 Also, please note that Jacques citations can be ambiguous about the species from which a data point is taken.

Adipose μ a Human: Bashkatov 2011 Adipose ◦ Citing Salomatina 2006 18 ◦ Integrating sphere, inverse Monte Carlo method Cow ◦ Citing Bashkatov 2005 16 Human ◦ Integrating sphere, inverse adding-doubling method 14 Human Mouse Absorbance (1/cm) Mouse: Alexandrakis 2005 12 ◦ Citing Mitic 1994, Kienle 1996, Holboke 2000, Rat 10 Srinivasan 2003 ◦ Previously used in SARRP Red Journal article 8 6 Rat: Bashkatov 2011 ◦ Citing Bashkatov 2005 4 ◦ Integrating sphere, inverse adding-doubling method 2 Cow: Kienle 1996 0 400 500 600 700 800 ◦ Spatially Resolved Absolute Diffuse Reflectance Wavelength (nm)

Adipose μ s ’ Cow: Kienle 1996 Adipose ◦ Spatially Resolved Absolute Diffuse Reflectance 60 Rat: Bashkatov 2011 Cow ◦ Citing Bashkatov 2005 Human ◦ Integrating sphere, inverse adding-doubling method 50 Human Human Reduced Scattering (1/cm) Mouse: Alexandrakis 2005 Human ◦ Citing Mitic 1994, Kienle 1996, Holboke 2000, Srinivasan 2003 40 Human Human Mouse: Wang 2015 ◦ Citing Jacques 2013 Mouse 30 ◦ Previously used in SARRP Red Journal article Mouse Rat Human: Bashkatov 2011 20 ◦ Citing Salomatina 2006 ◦ Integrating sphere, inverse Monte Carlo method 10 ◦ Citing Bashkatov 2005 ◦ Integrating sphere, inverse adding-doubling method 0 Human: Jacques 2013 ◦ Citing Salomatina 2006 (Fat) 400 500 600 700 800 ◦ Citing Salomatina 2006 (Adipocytes) Wavelength (nm) ◦ Citing Simpson 1998 ◦ Citing Peters 1990

Heart μ a Mouse: Alexandrakis 2005 Heart ◦ Citing Swartling 2003 7 Human Mouse: Wang Ge 2006 for range 650-700 nm Human 6 ◦ Citing Alexandrakis 2005 for formula Mouse 5 ◦ No citation for μ for Hb, HbO 2 , H 2 O Absorbance (1/cm) Mouse Human: Sandell 2011 4 ◦ Citing Dimofte 2009 3 ◦ Reported as range 0.03 to 1.55 cm -1 , not standard deviation ◦ Eight patients, properties determined before and after PDT 2 by analysis of diffuse reflectance spectra ◦ Citing Dimofte 2010 1 ◦ Reported as range 0.12 to 0.18 cm -1 , not standard deviation 0 ◦ Five patients, properties determined before and after PDT 400 500 600 700 800 by analysis of diffuse reflectance spectra Wavelength (nm)

Heart μ s ’ Human: Sandell 2011 Heart ◦ Citing Dimofte 2009 100 Human ◦ Reported as range 17.56 to 75.06 cm -1 , not standard 90 Human deviation 80 Mouse Reduced Scattering (1/cm) ◦ Eight patients, properties determined before and after PDT Mouse 70 by analysis of diffuse reflectance spectra 60 ◦ Citing Dimofte 2010 50 ◦ Reported as range 5.22 to 90.8 cm -1 , not standard deviation 40 ◦ Five patients, properties determined before and after PDT by analysis of diffuse reflectance spectra 30 20 Mouse: Alexandrakis 2005 10 ◦ Citing Swartling 2003 0 Mouse: Wang Ge 2006 for range 650 – 750 nm 400 500 600 700 800 Wavelength (nm) ◦ Citing Alexandrakis 2005 for formula

Kidney μ a Mouse: Alexandrakis 2005 Kidney ◦ Citing Solonenko 2002 8 Mouse 7 Mouse: Wang Ge 2006 for range 650-700 nm Mouse ◦ Citing Alexandrakis 2005 for formula 6 Absorbance (1/cm) ◦ No citation for μ for Hb, HbO 2 , H 2 O 5 4 3 2 1 0 400 500 600 700 800 Wavelength (nm)

Kidney μ s ’ Alexandrakis 2005 Kidney ◦ Citing Solonenko 2002 30 Mouse Wang Ge 2006 for range 650-700 nm 25 Mouse ◦ Citing Alexandrakis 2005 for formula Reduced Scattering (1/cm) 20 ◦ Note: likely to be error ◦ (41700 mm -1 ) (650) -1.51 = 2.359 mm -1 = 23.6 cm -1 15 ◦ (41700 mm -1 ) (700) -1.51 = 2.109 mm -1 = 21.1 cm -1 X 10 5 0 400 500 600 700 800 Wavelength (nm)

Liver μ a Cow: Cheong 1990 Liver ◦ Citing Karagiannes 1989 45 Cow Human: Cheong 1990 ◦ Citing Andreola 1988 Cow 40 ◦ Citing Marchesini 1989 Human 35 Human Mouse: Alexandrakis 2005 Absorbance (1/cm) 30 ◦ Citing Karagiannes 1989, Marchesini 1989, Parsa 1989, Kienle 1996, Beek 1997, Human Ritz 2001, Srinivasan 2003 25 Mouse Pig: Cheong 1990 Mouse 20 ◦ Citing Wilson 1986 Mouse 15 Mouse: Cheong 1990 Pig ◦ Citing Parsa 1989 10 ◦ See figure to right for hump around 550 nm 5 Mouse: Wang Ge 2006 ◦ Citing Alexandrakis 2005 0 400 500 600 700 800 Cow: Kienle 1996 Wavelength (nm) Human: Sandell 2011 ◦ Citing Wang HW 2003, 2005 Reported as range 1.15 to 1.56 cm -1 , not standard deviation ◦

Liver μ s ’ Human: Sandell 2011 ◦ Citing Wang HW 2003, 2006 Liver ◦ In situ measurement in PDT patients 35 Reported as range 21.6 to 30.4 cm -1 , not standard deviation ◦ Cow Mouse: Wang Ge 2006 for range 650-700 nm Cow 30 ◦ Citing Alexandrakis 2005 for formula Human Reduced Scattering (1/cm) ◦ Note: likely to be error 25 (629 mm -1 ) (650) -1.05 = 0.7 mm -1 = 7 cm -1 Human ◦ (792 mm -1 ) (700) -1.05 = 0.648 mm -1 = 6.48 cm -1 ◦ Mouse X 20 Mouse Pig: Cheong 1990 ◦ Citing Wilson 1986 15 Pig ◦ PDT study 10 Cow: Cheong 1990 ◦ Citing Karagiannes 1989 5 Human: Jacques 2013 ◦ Citing Parsa 1989 0 400 500 600 700 800 Mouse: Alexandrakis 2005 ◦ Citing Karagiannes 1989, Marchesini 1989, Parsa 1989, Kienle 1996, Beek 1997, Ritz 2001, Wavelength (nm) Srinivasan 2003 Cow: Kienle 1996

Lung μ a Human: Cheong 1990 Lung ◦ Citing Marchesini 1989 30 Mouse ◦ Integrating sphere, goniophotometry Mouse ◦ Citing Andreola 1988 25 Human Human Mouse: Alexandrakis 2005 Absorbance (1/cm) 20 Human ◦ Citing Beek 1997, Srinivasan 2003 Human 15 Mouse: Wang Ge 2006 for range 650-700 nm ◦ Citing Alexandrakis 2005 for formula 10 Human: Sandell 2011 5 ◦ Citing Dimofte 2009 Reported as range 0.16 to 1.36 cm -1 , not standard deviation ◦ 0 ◦ Citing Dimofte 2010 400 500 600 700 800 Wavelength (nm) Reported as range 0.49 to 0.88 cm -1 , not standard deviation ◦

Lung μ s ’ Human: Sandell 2011 Lung ◦ Citing Dimofte 2009 90 Human ◦ Reported as range 1.07 to 83.81 cm -1 , not standard deviation 80 Human ◦ Citing Dimofte 2010 Mouse 70 Reduced Scattering (1/cm) ◦ Reported as range 21.14 to 22.52 cm -1 , not standard deviation Mouse 60 Mouse: Alexandrakis 2005 50 ◦ Citing Beek 1997, Srinivasan 2003 40 Mouse: Wang Ge 2006 30 ◦ Citing Alexandrakis 2005 for formula 20 10 0 400 500 600 700 800 Wavelength (nm)

Stomach μ a Mouse: Wang Ge 2006 for range 650-700 nm Stomach ◦ Citing Alexandrakis 2005 for formula 6 Human ◦ Note: possible error Mouse 5 ◦ No citation for μ for Hb, HbO 2 , H 2 O Mouse Absorbance (1/cm) Human: Welch 2011 4 ◦ Citing Thueler 2003 3 ◦ Spatially resolved diffuse reflectance ◦ ±1.4, ±0.7, ±0.5 at 542 nm, 600 nm, 650 nm, 2 respectively 1 Mouse: Alexandrakis 2005 ◦ Citing Thueler 2003 0 400 500 600 700 800 Wavelength (nm)

Stomach μ s ’ Mouse: Wang Ge 2006 for range 650-700 nm Stomach ◦ Citing Alexandrakis 2005 for formula 20 Human ◦ Note: likely to be error 18 X Mouse ◦ (792 mm -1 ) (650) -0.97 = 1.48 mm -1 = 14.8 cm -1 16 Mouse Reduced Scattering (1/cm) ◦ (792 mm -1 ) (700) -0.97 = 1.38 mm -1 = 13.8 cm -1 14 12 Mouse: Alexandrakis 2005 10 ◦ Citing Thueler 2003 8 Human: Welch 2011 6 ◦ Citing Thueler 2003 4 ◦ Spatially resolved diffuse reflectance 2 ◦ ±3.5, ±2.0, ±1.0 at 542 nm, 600 nm, 650 nm, 0 respectively 400 500 600 700 800 Wavelength (nm)

Summary λ (nm) Alexandrakis SARRP Red Journal Adipose Heart Kidney Liver Lung Stomach Abdomen* Tumor** 0.431 6.65 7.45 39.90 21.08 1.29 0.431 3.8 μ a (cm -1 ) 590 ' (cm -1 ) 12.900 11.60 27.3 7.75 23.25 16.26 15.300 9.0 μ s 0.127 2.00 2.24 11.99 6.63 0.38 0.127 2.3 μ a (cm -1 ) 610 ' (cm -1 ) 12.700 11.00 26 7.50 22.85 15.74 14.600 7.6 μ s 0.069 1.08 1.21 6.45 3.59 0.21 0.069 1.9 μ a (cm -1 ) 630 ' (cm -1 ) 12.480 10.50 24.7 7.23 22.46 15.25 14.000 6.9 μ s 0.050 0.78 0.87 4.67 2.61 0.15 0.050 1.6 μ a (cm -1 ) 650 ' (cm -1 ) 12.270 10.10 23.6 7.00 22.09 14.80 13.500 6.6 μ s * SARRP abdomen μ a from Alexandrakis 2005, abdomen μ s ’ from Jacques 2013 ** SARRP tumor μ a and μ s ’ from Honda 2011