Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem - PowerPoint PPT Presentation

Mar 12, 2023 •281 likes •426 views

Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem cells Lineage potential Differentiation Progenitor cells Transdetermination De-differentiation Specialised cells Transdifferentiation Lymphocyte Reprogramming strategies

Cell Commitment and Epigenetic Memory
Reprogramming Embryonic stem cells Lineage potential Differentiation Progenitor cells Transdetermination De-differentiation Specialised cells Transdifferentiation Lymphocyte
Reprogramming strategies Somatic cell nuclear transfer (SCNT) Transcription-factor transduction Cell fusion
mES x hB Oct4 translocates 3h 6h 12h mES x hB hES hB 6h 12h 24h Nuclear volume increasing
ES hB hB mES x hB hES 24h Nucleoli reorganize H4K16ac increases H3K9me3 control mES x hB (PRC2 -/- ) H3S10ph increases HP1 α redistributes
MRC Clinical Sciences Centre and collaborators : Imperial College London Andrew deMello Neil Brockdorff • Tomomi Tsubouchi • Jorge Soza-Ried THANKS • Francesco Piccol Hakan Bagci • • Karen Brown • Irene Cantone • David Landeira Feng Li • • Matthias Merkenschlager and other members of the Lymphocyte Development Group (past and present)

Recommend

NIEjr01: Who is faster, 2n or 4n in Growth and Cell Fate Reprogramming? NTU x MGS Loh Kay-En

NIEjr01: Who is faster, 2n or 4n in Growth and Cell Fate Reprogramming? NTU x MGS Loh Kay-En Elizabeth, Faith Sze Xin Rei, Associate Professor Chen Zhong, Dr Yan An, Mr Lim Lee, Mrs May Liow 2 Background Information Background Background

1.23k views • 55 slides

MEMORY HIERARCHY RANDOM ACCESS MEMORY Key features RAM is traditionally packaged as a chip.

MEMORY HIERARCHY RANDOM ACCESS MEMORY Key features RAM is traditionally packaged as a chip. Basic storage unit is normally a cell (one bit per cell). Multiple RAM chips form a memory. RAM comes in two varieties: SRAM (Static

542 views • 40 slides

Coding Schemes for Inter-Cell Interference in Flash Memory Sarit Buzaglo UCSD Joint work with

Coding Schemes for Inter-Cell Interference in Flash Memory Sarit Buzaglo UCSD Joint work with Paul H. Siegel and Eitan Yaakobi Flash Memory and Inter-Cell Interference Flash memory structure: Block of cells: m word lines of length n.

868 views • 7 slides

Random Access Memory (RAM) Key features RAM is traditionally packaged as a chip.

Carnegie Mellon Random Access Memory (RAM) Key features RAM is traditionally packaged as a chip. Basic storage unit is normally a cell (one bit per cell). Multiple RAM chips form a memory. Static RAM (SRAM) Each

939 views • 62 slides

Breastmilk as Epigenetic Medium NPO Conference, Portland Oct 2018 Sylvia Metzger Objectives 1.

Breastmilk as Epigenetic Medium NPO Conference, Portland Oct 2018 Sylvia Metzger Objectives 1. Introduce the concept of epigenetics 2. Discuss epigenetic effects of breastmilk and lactation programming on infant health outcomes 3. Compare

931 views • 53 slides

Emerging Non Volatile Memory Resistive Memory Technologies Key concept: replace DRAM cell

Emerging Non Volatile Memory Resistive Memory Technologies Key concept: replace DRAM cell capacitor with a programmable resistor 1T-1C DRAM 1T-1R STT-MRAM, PCM, RRAM Charge based sensing Resistance based sensing

666 views • 19 slides

CS333 Intro to Operating Systems Jonathan Walpole Memory Management Memory Management Memory

CS333 Intro to Operating Systems Jonathan Walpole Memory Management Memory Management Memory a linear array of bytes - Holds O.S. and programs (processes) - Each cell (byte) is named by a unique memory address Recall, processes are

576 views • 55 slides

Christiane Querfeld, MD 2015... 2018 T-Cell Lymphomas: we are close to the finalization

Christiane Querfeld, MD 2015... 2018 T-Cell Lymphomas: we are close to the finalization Bologna, IT May 9, 2018 Epigenetic alterations have been implicated in the pathogenesis of lymphomas and leukemias including CTCL miRNA profiling

497 views • 24 slides

Synthesizing Stealthy Reprogramming Attacks on Cardiac Devices to appear in IEEE/ACM

Synthesizing Stealthy Reprogramming Attacks on Cardiac Devices to appear in IEEE/ACM International Conference Cyber-Physical Systems (ICCPS 2019) Nicola Paoletti Royal Holloway, University of London Joint work with: Scott A Smolka, Shan Lin,

599 views • 46 slides

Monitoring a and R Reprogramming the Im Immune S System Corporate P Presentation July 2

Monitoring a and R Reprogramming the Im Immune S System Corporate P Presentation July 2 2020 Nasdaq: A : ADTX 2 Safe Harbor bor Di Disclaimer This presentation contains forward-looking statements that are subject to many risks and

349 views • 30 slides

Memory Memory Decoders M bits M bits RWM NVRWM ROM S 0 S 0 Word 0 Word 0 S 1 Word 1 Word

Memory Memory Decoders M bits M bits RWM NVRWM ROM S 0 S 0 Word 0 Word 0 S 1 Word 1 Word 1 A 0 S 2 Storage Storage Random Non-Random Word 2 Word 2 N Words Cell A 1 Cell EPROM Mask-Programmed Decoder Access Access E 2 PROM

464 views • 21 slides

Systematic Investigation of Metabolic Reprogramming in Different Cancers Based on Tissue-specific

Shanghai Jiao Tong University Systematic Investigation of Metabolic Reprogramming in Different Cancers Based on Tissue-specific Metabolic Models Fangzhou Shen, Jian Li, Ying Zhu, Zhuo Wang zhuowang@sjtu.edu.cn Department of

553 views • 38 slides

Cellular Reprogramming and Controllability of Complex Systems University of Maryland and ISR

Cellular Reprogramming and Controllability of Complex Systems University of Maryland and ISR April 25, 2016 Roger Brockett John A. Paulson School of Engineering and Applied Science Harvard University 1 Metadata on the Talk In this talk I

757 views • 32 slides

Reprogramming microbes to cater to or silence their hosts Beta Carotene production and RNAi

Reprogramming microbes to cater to or silence their hosts Beta Carotene production and RNAi delivery David Johnston Monje, Brendan Hussey, Lisa Ledger, Mufaddal Girnary, Tin Vo, Jen Vo, Ed Ma, Emma Allen-Vandercoe, and Manish Raizada The

267 views • 24 slides

Zephyr: Efficient Incremental Reprogramming of Sensor Nodes using Function Call Indirections and

Zephyr: Efficient Incremental Reprogramming of Sensor Nodes using Function Call Indirections and Difference Computation Rajesh Krishna Panta Saurabh Bagchi Samuel P. Midkiff Dependable Computing Systems Laboratory (DCSL) Purdue University 1

255 views • 24 slides

Announcements Reprogramming HW2: Due on 3/16 (Wed), 2:30pm Mat: mobile code Hard

Middleware for Wireless Announcements Reprogramming HW2: Due on 3/16 (Wed), 2:30pm Mat: mobile code Hard deadline! Agilla: mobile agent Midterm Open book, note Chenyang Lu CSE 467S 1 Chenyang Lu CSE 467S 2

360 views • 5 slides

Cell Communication and Cell Signaling Why is cell signaling important? Why is cell signaling

Cell Communication and Cell Signaling Why is cell signaling important? Why is cell signaling important? Allows cells to communicate and coordinate functions/activities of the organism Usually involves the cell membrane Cell

408 views • 36 slides

Commitment Schemes A commitment scheme CS = ( P , C , V ) is a triple of algorithms P

Commitment Schemes A commitment scheme CS = ( P , C , V ) is a triple of algorithms P COMMITMENT SCHEMES EXAMPLE M C C K V 0/1 Parameter generation algorithm P is run once by a trusted party to produce public parameters . Mihir

1.22k views • 6 slides

Epigenetic Changes and Childhood Cancer (redacted slides, full set to be

Epigenetic Changes and Childhood Cancer (redacted slides, full set to be posted later) Joseph Wiemels Dept. of Epidemiology & Biosta7cs University of California, San

327 views • 28 slides

Working Energy Commitment Working Energy Commitment Founding Members Working Energy Commitment

Working Energy Commitment Working Energy Commitment Founding Members Working Energy Commitment Statement of Principles Operate safely and responsibly Meet or exceed all environmental standards Act with integrity Continually

766 views • 18 slides

SAT Approximations of PSPACE Problems for Cellular Reprogramming Loc Paulev CNRS/LRI, Univ.

SAT Approximations of PSPACE Problems for Cellular Reprogramming Loc Paulev CNRS/LRI, Univ. Paris-Sud, Univ. Paris-Saclay BioInfo team loic.pauleve@lri.fr http://loicpauleve.name Journes BIOSS-IA - 23 Juin 2017 SAT Approximations of

457 views • 18 slides

Memory Errors Bits in memory can be flipped Hard error The chip is broken E.g.,

Verilog Memory Errors Bits in memory can be flipped Hard error The chip is broken E.g., manufacturing defect, wear (in Flash) Soft error Stored data corrupted, but cell still works Caused by atmospheric neutrons, alpha

291 views • 7 slides

Memory II. Memory improvement III. Problems with memory 3 systems/stages of Memory: memory

Main Focus I. Memory as a process Memory II. Memory improvement III. Problems with memory 3 systems/stages of Memory: memory the process by which I. Sensory Memory information is - acquired, II. Short -Term Memory - stored,

169 views • 5 slides

Environmental exposures and mechanisms of transgenerational epigenetic inheritance To eat or not

Environmental exposures and mechanisms of transgenerational epigenetic inheritance To eat or not to eat: Is that the (only) question? Raquel Chamorro-Garcia Assistant Professor Department of Microbiology and Environmental Toxicology

908 views • 23 slides