Career Transitions Outside of Academia... The Wonderful World of - PowerPoint PPT Presentation

CONFIDENTIAL Career Transitions Outside of Academia... The Wonderful World of Drug Development Dr. Murray Webb Head, Pharmacology/Toxicology The Centre for Drug Research and Development (CDRD) 24 May 2015

Presentation Outline  The Industry Landscape  CDRD’s Place in the World  CDRD Training Program  My Own Career Path (lessons & advice) 2

The Industry Landscape 3

The Landscape.... Starting with Pharma: R&D Productivity has Declined 4

Biotech Has Been Booming NASDAQ Biotechnology Index *Drug approvals increasing *Novel technologies *Regulatory Incentives *M&A 5

Increasing Role of University R&D in Innovation Nature Biotechnology – Volume 32 Number 12 – December 2014 6

New Funds in Canada Bloom Burton 7

As a Result....Universities Increasing Their Focus on Startups 8

CDRD’s Place in The World 9

CDRD Vision and Mission Vision To transform the culture of scientific innovation and commercialization impacting human health Mission  To be a global leader in translating academic discoveries into new medicines  To bridge the commercialization gap between drug discovery and private investment by creating partnerships between academia, industry, foundations and government  To provide the next generation of uniquely-trained highly qualified personnel to drive the development of the medicines of tomorrow 10

CDRD’s Network of Affiliated and Partner Research Institutions CDRD HQ & Nodes Over 50 affiliated and partner Institutions around the world >10,000 Principal Investigators 11

CDRD’s Drug Development Platform  Target Validation  Screening  Medicinal Chemistry  Pharmacology/Toxicology  Analytical  Drug Delivery  Biologics (Antibody generation and immunotherapies)  125+ FTEs  40,000 sq. ft. of dedicated translational research space 12

Peroxisome Metabolic Infectious Diseases Biogenesis Peroxisome Anti-Bacterial Disorder Anti-Bacterial CDRD Project Biogenesis Disorder ALS Anti-Viral Cancer Portfolio Metabolic Parkinson’s Anti-Bacterial Sepsis Acute Lymphoblastic Anthelmintic Stage of Project Leukemia Obesity Anti-Bacterial Parkinson’s Glioblastoma In Discussion Anti-Bacterial Anti-Bacterial Incubation Projects Hematological Gram Neg. Bone Pain Brain Edema Malignancies Anti-Bacterial Approved Projects Obesity Schizophrenia Gram Neg. Commercialization Cancer Stem Cells Cancer ADCs Neuroscience Dyskinesia Oncology Lung Location of PI ADCs 12 Technologies Parkinson’s Commercialized British Columbia Cancer Neuropathic Alberta Pain Prostate Pancreatic Orphan Saskatchewan Diseases Cancer Cancer MS Seizures Manitoba Peritoneal Epithelial Dialysis Barrier Diseases Immunotherapy Ontario Glioblastoma ALS Wound Dry Eye Organ Asthma Quebec Healing Preservation IBD Nova Scotia Radiation- HPG Metastatic Cancer Schizophrenia / Induced GI IBD New Brunswick Epilepsy / Syndrome Biomarkers Aortic Valve Depression Inflammation Disease Newfoundland Asthma Chronic Airway International IBD Cystic Fibrosis Inflammation Asthma Atherosclerosis Last Updated 7 April 2015 Cardiac Fibrosis Myelofibrosis Respiratory Glomerulonephritis Other Indications

Our Track Record Thus Far…. 1,052 Potential Projects/Technologies Reviewed (Over 1,300 Principal Investigators engaged – increasing their commercial focus) 209 Projects Undertaken (on 134 Distinct Technologies ) 102 Projects - milestone data not 56 Projects Advanced Toward supportive of Commercialization and/or further development Commercialized at this time (+ 51 Ongoing) 12 technologies commercialized including: 5 Spin-Off Companies 3 Out-Licenses 4 Under Development/Management of CVI Mesentech Inc. (One product advanced into human trials) 14

CDRD Training Program 15

CDRD Training Program A new model to train Canada’s top future talent, ready to lead the building of the national life sciences industry, and take on the jobs of the 21 st century  Multi-disciplinary training in drug development  A fusion of best practices from both industry and academia  Participation in collaborative project teams  Professional development skills training  Workshops and seminars  Mentorship and coaching 16

Training Program Overview  Currently 20 in-house Trainees  Post-Doctoral Fellows (PDFs)  Co-op Students  Graduate Student Interns (GSIs)  Business Development Interns (BDIs)  Curriculum  Lab/On-the Job (OTJ) training  Workshop Series  Seminar Series  Mentorship Initiative  Networking Opportunities

Training Outcomes  110 Trainees to-date  92% of our Trainees are in full time employment in their chosen field of life sciences or further education  71 Workshops Sector  44 Seminars Employed in Life 4% 4% Sciences Further Study in 46% 46% Life Sciences Employed in Accounting / Banking Currently Seeking Employment 18

Recruiting Top International Talent Swedish Iranian Chinese Irish Rwandan British American Indian German Israeli French Peruvian Since 2009, we have recruited over 30 international trainees to our innovative program. 80% have remained in British Columbia 19

Trainee Profiles “ My training as a Post-Doc at CDRD was very different from that of an academic position. I had the opportunity to work on different projects and had scientific training in drug development, project management, and scientific communications. ” – Dr. Gesine Heuck, Former CDRD Post-Doctoral Fellow.  Dr. Gesine Heuck  Recruited to Drug Delivery and Formulations Division at CDRD  Completed her PharmD at Universities of Regensburg and Kiel, Germany, and the University of Michigan, US  Ph.D. at U. of Geneva focused on photodynamic therapy and fluorescent photodetection of cancer  Worked on a collaborative project with the Insitut Pasteur in France  As part of CDRD’s Training Program, she enhanced her knowledge of project management and business development  Following training at CDRD, Gesine has taken up a Research Scientist role with Precision NanoSystems in Vancouver 20

My Own Career Path (lessons & advice) 21

My Career Path to CDRD  Ph.D. at UBC; plant biochemistry/photosynthesis/electron transport  PostDoc, Cornell, 4 years, membrane biochem/biophysics, temperature stress  Switch to Cancer AND switch to Industry – Inex Pharmaceuticals  1 st project cancelled within 3 months!  Switch to new project – within 6 months had invented/discovered Marqibo – FDA- approved for ALL  Switch to Clinical and Regulatory Affairs – Inex Pharmaceutical  Major opportunity to learn Clinical/Regulatory, get FDA experience etc.  Celator Pharmaceuticals, Panagin Pharmaceuticals & CDRD 22

Lessons Learned and Concluding Advice….  Relationships are the key to success  Network beyond your immediate area of interest  You never know when those relationships will prove valuable  Never let your circumstances or environment limit your opportunities  The importance of mentors  Be better than your competitors  Position yourself as the Gold Standard  Be open to unique opportunities when they present themselves  Be flexible – willing to do anything and learn everything  Stretch your skill-set base into multiple functions  Generalists vs. Specialists  Have an entrepreneurial mind set  Go global (and return) – everything is global! 23

Resources  University Professors – Outlook  Service Canada  http://www.servicecanada.gc.ca/eng/qc/job_futures/statistics/4121.shtml  “Where Are Canada’s PhDs Employed?”  Conference Board of Canada  http://www.conferenceboard.ca/topics/education/commentaries/15-01- 06/where_are_canada_s_phds_employed.aspx  University Affairs  http://www.universityaffairs.ca/opinion/speculative-diction/stats/  Universities Canada  http://www.univcan.ca/wp-content/uploads/2011/05/trends-2011-vol1-enrolment-e.pdf (skip to page 32). 24

For additional information on The Centre for Drug Research and Development (CDRD), please visit us at…. www.cdrd.ca 25