Biomaterials: biological origin or application? Andrés Vercik Grupo de Nanotecnologia, Biomateriais e Dispositivos (www.usp.br\nanobiodev) Faculdade de Zootecnia e Engenharia de Alimentos Universidade de São Paulo Biomaterials: biological origin or application?
Motivation Concept Accuracy Words Science Precision Terms Names Biomaterials: biological origin or application?
Example: Stent • Intravascular stent • Stented heart valve • Stent-graft • Stent-valve Biomaterials: biological origin or application?
Example: dislocation Biomaterials: biological origin or application?
Roots: multiple meanings nano Bio • Nanotechnology • Biopolymers • Nanostructure • Bioceramics • Nanomaterials • Biomaterials • Biomedical materials Nanostructured material Biomaterials: biological origin or application?
XII SBPMat – Symposium H Different Sym posium H dow nload New Trends in Biom aterials and Nanom aterials Applied to Biosystem s Scope: The symposium will provide a platform for discussing current advancements and future trends in biomaterials for biomedical and dental applications and nanomaterials applied to biosystems. Through the synergistic approach of applied chemistry and physics, material science, electronics, mechanical engineering, biochemistry and medicine, this symposium about biomaterials includes how the deeper insight into biological events and its interplay with nanotechnology may support the development of a generation of novel materials, micro-nano-devices and molecular level approaches suited to solve relevant biomedical problems both for therapy and diagnostics. New materials also play an important role in veterinary, agriculture, biotechnology, smart packaging, food industry and natural environment. The subject matter of the symposium reflects the wide range and transdisciplinary nature of research in materials science and engineering applied to biological systems. The symposium will provide an excellent opportunity to meet and establish collaboration with large number of experts with several specializations including engineering, basic sciences, pharmacists, medical and dental professionals, etc. Phenomena Words Session Topics: Biomaterials in constructing tissue substitutes Synthetic scaffolds as extracellular matrices Bioinspired and biomimetic materials Anti-infective biomaterials Adhesive biomaterials Biomaterials for cardiovascular applications, vascular grafts and embolic devices Biomaterials for cancer therapy Biomaterials for orthopedic and ophthalmic applications Controlled Release Biomaterials in dental applications Materials applied to Agriculture, smart packaging Biodegradable Polymers, Polymers from Renewable Resources and Hydrogels Nanotoxicology and Nanoecotoxicology Same Sensors and Biosensors Tentative List I nvited Speakers: Mitsuo Niinomi, Institute for Materials Research Biomaterials Science, Japan Thierry Gloriant, Institut National des Sciences Appliqu é es - INSA, France Yannis Missirlis, University of Patras, Laboratory of Biomechanics and Biomedical Engineering, Greece Garrett B. McGuinness, Dublin City University, Centre for Medical Engineering, Research, Ireland Ketul C. Popat, Colorado State University, USA Pedro L. Granja, Instituto de Ci ê ncias Biom é dicas, Portugal Jonny Blake, Imperial College, UK Alexander L. Yarin, University of Illinois, USA Sym posium organizers: ú ú tá é Biomaterials: biological origin or application?
Biomaterials Biomaterials Biomaterials Biomaterials: biological origin or application?
Talk outline • Definitions of bio-things • Examples of bio-things (to make us change our minds) • Let’s try a new definition? • Rules of the game Biomaterials: biological origin or application?
Accuracy - Definitions Biosensor (IUPAC 1999) Biomaterials (Williams 1999) “a self-contained integrated device , “a material intended to interface with which is capable of providing specific biological system to evaluate, treat, quantitative or semi-quantitative augment or replace any tissue, organ, or analytical information using a biological function of the body ” recognition element (biochemical receptor) which is retained in direct spatial contact with an electrochemical transduction element” The Williams dictionary of biomaterials. University D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No. Press, 1999. 12, pp. 2333-2348, 1999. Biomaterials: biological origin or application?
Accuracy - Definitions Biosensor Biomaterials Evaluate Biological Biological Treat Material Transducer Sense Augment Element System Replace Biomaterials: biological origin or application?
Accuracy - Definitions Biosensor (IUPAC 1999) Biomaterials (Williams 2009) “a substance that has been engineered “a self-contained integrated device , to take a form which, alone or as part of which is capable of providing specific a complex system, is used to direct, by quantitative or semi-quantitative control of interactions with analytical information using a biological components of living systems , the recognition element (biochemical receptor) which is retained in direct course of any therapeutic or diagnosis spatial contact with an electrochemical procedure, in human or veterinary medicine ” transduction element” D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No. D. F. Williams, Biomaterials 30 (2009) 5897-5909. 12, pp. 2333-2348, 1999. Biomaterials: biological origin or application?
Concept of Biological System (element) Biomaterials community vision There are many more living things 1999 2009 1999 Biomaterials: biological origin or application?
Is it a biomaterial? • • Titanium Collagen • • Steel Cellulose • • Silicon Gelatin Application? Origin? • • Gold Chitosan • • Silver Wood Biomaterials: biological origin or application?
Neurons on silicon Nanoelectronic scaffolds Is it a biomaterial? Scaffold Yes Biosensor No B. Tian et al., Nature Materials 11 (2012) 986-994 Biomaterials: biological origin or application?
Energy harvesting Biomaterials: biological origin or application?
Biofuel cell J. Ma, Y. Sahai / Carbohydrate Polymers 92 (2013) 955 – 975 M. Holzinger et al., D. Leech et al., Electrochimica Electrochimica Acta 82 (2012) Acta 84 (2012) 223 – 234 179 – 190 A. Zebda et al., Nature Communications DoI: 10.1038/1365. A. Zebda et al., Scientific Reports 3: 1516 (2013) 1-5 Biomaterials: biological origin or application?
Biodegradable electronics M. Irimia-Vladu et al., Materials today 15 (2012) 340-346. Biomaterials: biological origin or application?
Theragnostics P. Rai et al., Advanced Drug Delivery Reviews 62 (2010) 1094 – 1124 Biomaterials: biological origin or application?
Is it a biomaterial? Biomaterial (Natural or synthetic) Natural Material • Titanium • Collagen • Steel • Cellulose Application? Origin? • Silicon • Gelatin • Gold • Chitosan • Silver • Wood Biomaterials: biological origin or application?
Is it a biomaterial? Yes Origin Application No Biomaterials: biological origin or application?
Let’s try a definition • a substance that has been engineered • alone or as part of a complex system • is used to do something (direct…) • control of interactions with components of living systems • therapeutic or diagnosis procedure, in human or veterinary medicine • Intended to work in intimate spatial contact with a biological system Biomaterials: biological origin or application?
Biomaterial “a material intended to interface with a biological system” Biomaterials: biological origin or application?
Biomaterial “an engineered substance that, alone or as part of a complex system, is devised to interface (or to work) in intimate (spatial) contact with a biological system, by controlling their (mutual) interactions” Biomaterials: biological origin or application?
Interactions Material on biology Biology on material • Toxicity • Cell or protein adhesion • Rejection • Corrosion • Necropsy • Interference • Induction • Activity Biomaterials: biological origin or application?
Rules of the game: Foul Yes! No! Biomaterials: biological origin or application?
When I use a word, it means what I choose it to mean, neither more nor less Thank you! Biomaterials: biological origin or application?
Recommend
More recommend
