Bio-Gene Technology Company Overview May 2018 “AN AGTECH DEVELOPMENT COMPANY ENABLING A NEW GENERATION OF NOVEL INSECTICIDES THAT ADDRESS INSECTICIDE RESISTANCE” 1 Not for Distribution
BIO‐GENE SNAPSHOT Data shows initial products Flavocide™ & Qcide™ can be highly effective for insect management Potentially suitable for commercialisation as multiple target insecticides BETA-TRIKETONES Platform Technology Collaborate with commercial partners to bring multiple insect An insecticide Key technology enabling a indications to market technology & IP new generation of novel development insecticides to address the company increasing problem of insecticide resistance Targeting public health, animal health & crop protection sectors 2
EXECUTIVE SUMMARY Novel insecticide Unique (new) mode of action (MoA) identified – alternative chemistry to current incumbent platform leading to new insecticides in a market seeking new products – opportunities in a range of market segments effective products with multiple revenue sources Significant test results (& new tests underway with world leading institutions) demonstrate Strong test data effectiveness of Flavocide™ & Qcide™ at controlling resistant pests, as well as product safety Aim to establish strategic testing partnerships with multinational public health, animal health Multinational & crop protection & consumer companies as part of Bio-Gene’s partnership & partnerships targeted commercialisation strategy Manufacturing optimisation project To produce Flavocide™ at commercial rates & pricing underway with CSIRO Established global Growing IP portfolio with additional applications filed patents Appointment of new board members & Diverse skill set with significant industry experience advisors 3
BOARD MEMBERS & MANAGEMENT PETER MAY RICHARD JAGGER DON BRUMLEY CEO & Managing Director Executive Director, R & D Non-Executive Chairman • 25+ years as a senior partner & leader of • 20+ years working in agriculture globally • 20+ years experience in crop protection Ernst & Young – Oceania market with companies Orica & Crop Care • Most recently employed as Managing Australasia (now Nufarm) • Significant experience across IPOs, Director of Sinochem Australia transactions, audit & advising growing • Founded Xavca, consulted to companies • Previously spent 15+ years at Monsanto in entrepreneurial companies such as Syngenta & Sorex (BASF) various management roles • Former CEO & Chairman of BioProspect (now Medibio, ASX:MEB) ROGER MCPHERSON ROBERT KLUPACS KEVIN RUMBLE Chief Financial Officer & Non-Executive Director Non-Executive Director Company Secretary • 30+ years corporate experience in • Founding Director of Bio-Gene • 15+ years experience as CFO & Company international tech development Secretary across both listed & unlisted • 20+ years experience in new plant companies propagation, farming & live plant • Previously MD & CEO of ASX-listed Circadian Technologies Ltd transport techniques • Experience in the pharma manufacturing, biotech & biopharma industries • Previously MD & CEO of ES Cell • Involved in the development of Qcide TM & development of Flavesone as a first International Pte Ltd • Previously CFO & Co-Sec of TPI step in the commercialisation of Enterprises (ASX:TPI) • Registered Australian patent attorney Flavocide TM 4
KEY ADVISORS TO THE BOARD PROF. CATHERINE HILL NEIL ANDERSON DOUG RATHBONE Purdue University Chemistry & Manufacturing Consultant BGT Scientific Advisory Advisor to the BGT Board Board Member • Industrial Chemist • 40+ years experience in agriculture, • Purdue University, Dept. of most recently as Managing Director Entomology • Employed by Monsanto for 40 years of Nufarm, a position he held for 15+ • Showalter Faculty Scholar • Specialist in formulation years • President’s Fellow for the Life development, production, & process • Under his leadership, Nufarm became Sciences management one of Australia’s most successful • Authority in new insecticide • Qualified for manufacturing plant agricultural firms with global sales development & novel chemistry audits, quality & environmental >$2.5B management 5
BIO‐GENE TECHNOLOGY APPROACH BETA-TRIKETONES: PLATFORM TECHNOLOGY Synthetic = Replicable at commercial quantities (SCALABLE) FLAVOCIDE TM QCIDE TM SYNTHETIC COMPOUND, NATURAL OIL PRODUCT, FLAVESONE TASMANONE CONSUMER ANIMAL HEALTH PUBLIC HEALTH CROP PROTECTION APPLICATIONS Targeted pest/animal Targeted pest/vector Targeted pest/crop Targeted applications combinations combination combinations AIM: BRING TO MARKET A BROAD PORTFOLIO OF TARGETED INSECT CONTROL MANAGEMENT SOLUTIONS Near-term consumer opportunities available with Qcide™ 6
NOVEL MODE OF ACTION (EXAMPLE CROP PROTECTION) Taken 8% market share & US$1.4B sales per annum Still US$1.7B in sales per today annum today Group 1 Group 11 Group 17 Group 23 Group 28 ACETYLCHOLINESTERA MICROBIAL MOULTING INHIBITORS OF RYANODINE SE (ACHE) INHIBITORS DISRUPTORS OF DISRUPTOR, DIPTERAN ACETYL COA RECEPTOR (Organophosphates) INSECT MIDGUT CARBOXYLASE MODULATORS MEMBRANES (Diamides) 1944 1968 1970 1977 1985 1990 2002 2005 2008 2018 New Group? Qcide™ & Group 12 Group 3 Group 4 Group 29 Flavocide™ INHIBITORS OF SODIUM CHANNEL (NACHR) COMPETITIVE CHORDOTONAL MITOCHONDRIAL ATP MODULATORS MODULATORS ORGAN MODULATORS SYNTHASE (Pyrethroids) (Neonicotinoids) Potential for new IRAC classification. Significant market US$2.7B in sales US$4.6B in sales potential based on per annum today per annum today performance of other classes coming to market Currently performing research to identify specific sites within the known unique channel 7
LARGE GLOBAL, GROWING MARKETS Industry dominated by multi- national AgChem companies Consumer Applications $5.1B Sprays, Baits, Repellants Animal Health $6.0B Livestock, Pets Seeking Safe Novel Solutions to complement off-patent insecticides Crop Protection $16.0B Public Health Food, fibre, $4.0B grain storage Malaria, Zika, Dengue AgTech with access to new technology platform leading to new insecticides desired by AgChem industry 8
SEGMENTS / PESTS SEGMENT PESTS Ectoparasites (ruminants): cattle tick ( Rhipicephalus microplus ), buffalo fly Animal health Ectoparasites (companion animals): paralysis tick, fleas Public health Mosquitoes, flies Urban pests Flying pests, cockroaches, ants, other crawling pests Lesser grain borer ( Rhyzopertha dominica ), Grain storage Flat grain beetle ( Cryptolestes spp.) & others Lab & microcosm bioassays: Red legged earth mite ( Halotydeus destructor ) Green peach aphid Russian wheat aphid Diamondback moth Helicoverpa armigera Crop Field testing: Two-spotted mite Cotton aphid White fly Lepidopterous larvae Brown plant hopper (rice; Thailand) 9
PROGRESS & GOALS BGT continues to build a suite of research data across a number of pests and verticals Research Legend: Initial Follow Up Commercial Product Partner Testing Testing Partnership Development Committed Complete Beneficial Arthropods Underway / Agreed Upon Lesser Grain Borer Other Grain Storage Pests Russian Wheat Aphid Green Peach Aphid Crop Diamond Backed Moth Protection Cotton Bollworm Brown Planthopper Silverleaf Whitefly Red legged Earthmite Two Spotted Mite Aedes aegypti Mosquito Public Culex Mosquito Health Anopheles Mosquito Mosquito Consumer Housefly Crawling Pests Cattle Tick Animal Health Buffalo Fly Initial testing has demonstrated control of susceptible & resistant populations 10 10 Company Announcements & Henslow Estimates
GRAIN STORAGE PESTS Combination treatments with Flavocide™ shown to control the full spectrum of key pests evaluated, including strains resistant to currently used insecticides Demonstrates the compatibility of Flavocide™ with resistance management strategies currently being used in the grain protection industry 11
GREEN PEACH APHID Control of susceptible and highly resistant strains of Green peach aphid demonstrated Flavocide™ outperforms Pirimicarb (a commonly used insecticide) in control of a highly resistant strain of the pest 12
TOXICOLOGY UPDATE Flavocide TM Completed acute toxicity six pack Mutagenicity & carcinogenicity tests completed Chronic toxicity testing – seven day sighting study completed 28 day toxicity study (dermal & oral) commenced Physical/chemical studies completed Qcide TM Preliminary toxicity testing completed Acute toxicity six pack commencing 13
GROWING INTELLECTUAL PROPERTY Key granted patents in key "METHODS & COMPOSITIONS territories covering the use of FOR CONTROLLING PESTS" beta-triketones as insecticides Platform patent family Expiring 2022 Insect/crop combination Insect/animal combination Manufacturing patent families patent families processes Trade secrets Recent provisional patent New patent lodgings relate Further filings over next 6-24 filings which, when granted, to control of resistant months covering specific extend patent life to 2038 populations, and impact on combinations, specific resistant synergy with existing pest control, new formulations, Data currently generated for chemistry dose ranges etc submission mid year 14
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