ASX ANNOUNCEMENT 13 DECEMBER 2019 PRESENTATION ON BREAKTHROUGH IN CONTROL OF RESISTANT MOSQUITOES Bio-Gene Technology Limited (ASX: BGT, ‘ Bio-Gene ’ or the ‘ Company ’ ) is pleased to release this slide presentation relating to the recent Bio-Gene announcement “ Significant Breakthrough in Control of Resistant Malaria Mosquitoes ” and providing further information on insecticide resistant mosquitoes and public health. Approved for release by the Chairman of the Bio-Gene Board of Directors. - ENDS - For further information, please contact: Bio-Gene Technology Limited: Media: Investor Relations: Richard Jagger Natalee Ward Davina Gunn Chief Executive Officer Porter Novelli Henslow P: 03 9068 1062 P: 0408 377 901 P: 0400 896 809 E: bgt.info@bio-gene.com.au E: nw ard@porternovelli.com.au E: dgunn@henslow.com About Bio-Gene Technology Limited Bio-Gene is an Australian ag-tech development company enabling the next generation of novel insecticides to address the global problems of insecticide resistance and toxicity. Its novel platform technology is based on a naturally occurring class of chemicals known as beta-triketones. Beta-triketone compounds have demonstrated insecticidal activity (e.g. kill or knock down insects) via a novel mode of action in testing performed to date. This platform may provide multiple potential new solutions for insecticide manufacturers in applications across crop protection and food storage, public health, consumer applications and animal health. The Company’s aim is to develop and commercialise a broad portfolio of targeted insect control and management solutions. Bio-Gene Technology Limited ABN: 32 071 735 950 Level 11, 456 Lonsdale Street, Melbourne, VIC 3000
ASX: BGT Breakthrough in control of resistant mosquitos 13 December 2019
The increasing Incidence of Three Major Vector-borne Diseases problem of global vector-borne diseases Major vector-borne diseases Countries that have reported account for 17% of the estimated infections of global burden of communicable either Zika, Malaria and / or diseases & claim >700,000 lives Dengue every year 50% >219m >400,000 $12bn Malaria Of global population are at Currently have Die every year Annual economic impact risk of exposure to Malaria Malaria from malaria of Malaria in Africa >40% 390m >25,000 30x Dengue Live in an area at risk of Dengue infections Deaths from Dengue Increase in dengue in Dengue Fever annually each year past 50-years $10m 86 76 $1.1bn Zika Lifetime healthcare cost for Countries reported mosquito- Reported detections Provided by US Congress in child infected in utero borne Zika virus at in Australia 2016 to combat zika Feb 2018 2
Vector-borne diseases are a “The issue of vector -borne disease is a rapidly growing global growing problem problem due to increasing insecticide resistance, population growth, urbanisation, travel, and climate change. Currently more than half of the world’s population is at risk of vector-borne diseases. Globally there are more than 200 million cases of malaria and over 400,000 people die from the disease every year, most of them children under the age of five. Zika virus has been declared a global health emergency, and death due to dengue fever has increased 30 fold in the last 50 years. Collectively, it is estimated that mosquito-borne diseases such as malaria, dengue, zika claim over 700,000 deaths every year. In addition, these diseases are known to exacerbate poverty and prevent economic development. Unfortunately, the effectiveness of currently used insecticides is diminishing due to resistance.” Prof. Catherine Hill BGT Scientific Advisor 3
Insecticide New insecticides are increasingly elusive Increasing number of resistant species resistance >140,000 molecules must be Species Resistant Molecules Screened 160,000 700 586 insect species now screened to discover a new resistant to at least one compound insecticide class 140,000 600 120,000 500 100,000 Resistance is rapidly 400 increasing while our ability to 80,000 find a solution diminishes 300 60,000 200 40,000 100 20,000 0 0 1930 1940 1950 1960 1970 1980 1990 2000 2010 2014 1950 1960 1970 1980 1990 2000 2010 Widespread resistance has been recorded in all major malaria vectors across the four most commonly used insecticide classes: • Pyrethroids • Organochlorine • Carbamates • Organophosphates 4
New solutions are needed to address resistance & toxicity Increasing incidence of resistance threatens effectiveness of existing controls Significant concern over the toxicity of existing and new insecticides to the environment EU bans a number of Neonicotinoids, (the most widely used insecticide class) for outdoor use due to bee safety concerns *CLICK LINKS TO LAUNCH ARTICLES 5
Mosquito Species Infectious diseases spread Aedes sp. Anopheles sp. Culex sp. via mosquitoes Zika Virus ✔ - - 42 countries Dengue Fever - - 390m infections ✔ Yellow Fever ✔ - - 30,000 deaths Disease Carried Malaria - - 219m infections ✔ Resistance to commonly used 47 states in the US with insecticides is evident in all key West Nile Virus - - ✔ infections mosquito species; hampering 2019 cases in Ethiopia, Thailand efforts to control disease Chikungunya - - ✔ & Brazil worldwide 5,000 infections annually in Ross River - - ✔ Australia Organochlorines Discovered 1930 ✖ ✖ ✖ Resistance Recorded Organophosphates Discovered 1944 ✖ ✖ ✖ Pyrethroids ✖ ✖ ✖ Discovered 1977 Carbamates Discovered 1950 ✖ ✖ ✖ Legend Infectious disease carried ✔ 6 ✖ Resistance recorded
History of WHO-approved insecticides for adult Malaria Mosquito control Malaria mosquito resistance 1940's 1950's 1960's 1970's 1980's 1990's 2000's 2010's Chlorfenapyr Pirimiphos- Alpha- DDT Malathion Fenitrothion (2017) methyl cypermethrin Lindane Propoxur Bendiocarb Cyfluthrin Widespread resistance is leading to multiple incidences of failure Chlorpyrifos- Lambda- Permethrin methyl cyhalothrin to prevent Malaria outbreaks Nearly all insecticide classes Cypermethrin Deltamethrin used for malaria mosquito control are over 40-years old, with the vast majority now Bifenthrin experiencing resistance and toxicity issues Etofenprox Organochlorines Organophosphates Carbamates Pyrethroids Pyrroles Yes. Monitoring Toxicity Banned in agriculture Yes Low Low recommended Yes, and cross Yes, and cross Yes, and cross Widespread Global Limited Resistance resistance with resistance with resistance with Resistance Use 7 pyrethroids carbamates organophosphates
Critical intervention methods Contribution of Malaria Control Intervention in Africa Tarsal absorption Insecticide- treated bed nets (‘ ITN ’) via insecticide are the most common method to treated bed nets control Malaria mosquitoes Insecticide-treated Bednets (ITN) 22% At least 700 million ITNs have * Artemisinin-based combination therapy been distributed in Africa since 10% 2000 68% Indoor residual spraying Most Common Intervention Methods: 1) Insecticide-treated bed nets are infused with insecticides providing: • A physical barrier protection; and • Control of mosquitoes via contact with the net & absorption of the insecticide through the tarsi (feet) 2) Indoor residual spraying with contact insecticides is also an important component of Malaria control strategies 8 *WHO recommended drug therapy for malarial cases
Bio-Gene is well placed to deliver a solution
Bio- Gene’s • Flavocide™ is a ‘ nature identical mimic ’ of a natural compound that can be Safe mass produced for vector control technology Chemistry • Low toxicity to bees & beneficial insects, favourable safety profile for use addresses market needs • Efficacy Testing to date confirms potential for controlling resistant pests across multiple markets • Novel Mode Operates via a novel Mode of Action, potentially addressing resistance to other of Action classes of chemistry Our proprietary chemistry represents a step-change for resistant mosquito control • Scalability Production processes are refined, scale-up in progress • Proven synergy in combinations with synthetic pyrethroids – the most commonly Synergies & Combinations used mosquito insecticides Control of • Multiple Potential to impact pest populations by controlling adults and offspring Generations 10
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