AOPT 10 th Scientific Meeting February 17 – 20, 2011 • Fort Worth, Texas AGENDA THURSDAY, FEBRUARY 17 th 5:00 – 7:00 PM Registration & Welcome Reception FRIDAY, FEBRUARY 18 th 7:00 – 9:00 AM Shuttle Available from the Courtyard Marriott Downtown to UNTHSC Registration, Exhibits, & Continental Breakfast 7:30 – 8:00 AM 8:00 – 8:15 AM Welcome & Opening Remarks 8:15 – 9:00 AM Keynote Address William Hauswirth, PhD “Cone Targeted Gene Therapy” University of Florida College of Medicine 9:00 – 10:30 AM New Approaches to Drug Delivery Including Nanotechnology Peter Kador, PhD, Session Co-Chair University of Nebraska Medical Center Hank Edelhauser, PhD, Session Co-Chair “Transscleral Drug Delivery” Emory University Susan Lee, MS “Understanding the Dynamics of Ocular Drug Distribution with 3D MRI” University of Southern California Samirkumar Patel, PhD “Targeting to the Surprachoroidal Space of the Eye Using a Hollow Microneedle” Georgia Institute of Technology Uday Kompella, PhD “Topical Nanosystems for Drug Delivery” University of Colorado Denver James Hill, PhD “Human Apolipoprotein E (APOE) Mimetic Peptide Inhibits Corneal Louisiana State University Health Science Center Neovascularization” 10:30 – 10:45 AM Break & Exhibits 10:45 – 12:15 PM Ocular Inflammation Including Dry Eye & Anti-Infectives Jerry Niederkorn, PhD, Session Chair “Role of Regulatory T-cells in Promoting Corneal Allograft Survival and Ocular University of Texas Southwestern Medical Center Immune Privilege” Hassan Alizadeh, PhD “The Role of Antimicrobial Peptides at the Ocular Surface” University of North Texas Health Science Center Michelle Callegan, PhD “Beneficial Antimicrobial Treatment of Spore-induced Bacillus Cereus University of Oklahoma Health Science Center Endophthalmitis” Daniel Gamache, PhD “Therapeutic Effects of PDE4 Inhibition in Dry Eye” Alcon Research Ltd. L. David Waterbury, MD, PhD “Cycloxygenase (COX-1) Versus COX-2 Inhibition to Alleviate Lipopolysaccharide Raven Biosolutions, LLC (LPS)-Induced Ocular Inflammation in a Rabbit Model” 12:15 – 1:00 PM Lunch & Exhibits 1:00 – 2:45 PM Animal Models of Ocular Disease Richard Libby, PhD, Session Chair “Using Mouse Models to Identify Critical Signaling Pathways in Glaucmatous University of Rochester Neurodegeneration” Dennis Rice, PhD “Mouse Models of Retinal Vascular Disease” Lexicon Pharmaceuticals Cathrine Bowes Rickman, PhD “Anti-amyloid Immunotherapy Blocks RPE Damage and Visual Function Defects in Duke University an AMD-like Mouse” Michael Anderson, PhD “Central Corneal Thickness as an Endophenotype of Glaucoma” University of Iowa Health Care Colleen McDowell, PhD “A New Mouse Model of Human Primary Open-angle Glaucoma” University of North Texas Health Science Center 2:45 – 3:00 PM Break & Exhibits Not Final Agenda. Schedule Subject to Change.
3:00 – 4:45 PM Ocular Blood Flow Jeff Kiel, PhD, Session Chair “Effect of Phentolamine on Ocular Hydrodynamic Response to Tilt in the Rabbit” University of Texas HSC San Antonio Malinda Fitzgerald, PhD, Moderator University of Tennessee Health Science Center Norman Harris, PhD “Inhibition of 20-HETE Attenuates Streptozotocin-induced Decreases in Retinal Louisiana State University Health Science Center Blood Flow” Herbert Reitsamer, PhD “Choroidal Vasodilation in Response to Facial Nerve Stimulation is Frequency Paracelsus University Salzburg Dependent and can be Modulated by L-NAME” Anton Reiner, PhD “Facial Parasympathetic Circuitry Regulating Choroidal Blood Flow” University of Tennessee Health Science Center Oliver Zeitz, MD, PhD “Altered Ocular Perfusion in Glaucoma Patients: The Importance of Methods to Bayer HealthCare Challenge Autoregulation for Clinical Trials” Travis Hein, PhD “RHO Kinase-Mediated Constriction of Porcine and Human Retinal Arterioles to Texas A&M University Endothelin-1” 4:00 – 6:30 PM Shuttle Available from UNTHSC to the Courtyard Marriott Downtown 4:45 – 5:15 PM AOPT Member Business Meeting 4:45 – 6:15 PM Poster Session & Hors D’oeuvres SATURDAY, FEBRUARY 19 th 7:00 – 9:00 AM Shuttle Available from the Courtyard Marriott Downtown to UNTHSC 7:30 – 8:15 AM Registration, Exhibits, & Continental Breakfast 8:15 – 10:00 AM Diabetic Retinopathy Timothy Kern, PhD, Session Chair “Beneficial Effects of Rate-IG Fusion Protein on Early Diabetic Retinopathy and Case Western Reserve University Tactile Allodynia” Jena Steinle, PhD “Compound 49B Prevents Neuronal and Vascular Cell Damage in Diabetic Rat” University of Tennessee Health Science Center Rose Gubitosi-Klug, MD, PhD “Role of Prostenoids in Diabetic Retinopathy” Case Western Reserve University Jian-Xing Ma, MD, PhD “Therapeutic Effect of an Antibody Blocking a WNT Receptor on Diabetic University of Oklahoma Health Science Center Retinopathy” Yun-Zheng Le, PhD “Visulizing and Quantifying Outer Blood-retina Barrier Breakdown: Implications in University of Oklahoma Health Science Center Finding a Cure for Macular Edema” 10:00 – 10:15 AM Break & Exhibits Biomarkers for Ocular Diseases & Therapies 10:15 – 12:00 PM John Crabb, PhD, Session Chair and Moderator “Biomarkers for Age-Related Macular Degeneration” Cleveland Clinic Kevin Schey, PhD “Maldi Imaging Mass Spectrometry: A New Approach to Biomarker Detection in Vanderbilt University Ocular Tissues” Yogen Saunthararajah, MD “A Pathway Based Approach to Biomarker Identification in Uveal Melanoma” Cleveland Clinic Kathryn Bollinger, MD “Glaucoma Biomarker Discovery using Quantitative Proteomics Analysis of TGF- Medical College Georgia Beta and Dexamethasone Treated Trabecular Meshwork Cells” 12:00 – 1:00 PM Lunch & Exhibits 1:00 – 2:45 PM Ocular Gene & Stem Cell Therapy Paul Kaufman, MD, Session Co-Chair University of Wisconsin Abe Clark, PhD, Session Co-Chair University of North Texas Health Science Center Marina Gorbatyuk, PhD “Endoplasmic Reticulum Stress in Retinal Degeneration of P23H Rhodopsin University of North Texas Health Science Center Transgenic Rats” Terete Borras, PhD “Gene Therapy and Glaucoma” University of North Carolina Not Final Agenda. Schedule Subject to Change.
David Gamm, MD, PhD “The Prospect of Customized Stem Cell Therapy for Retinal Degenerative Diseases” University of Wisconsin Gou-Tong Xu, PhD “Intervention of Retinal Degeneration in Rats with Erythropoietin Gene-modified Tongji Eye Institute Mesenchymal Stem Cells” 2:45 – 3:00 PM Break & Exhibits 3:00 – 4:45 PM Macular Degeneration Joe Hollyfield, PhD, Session Chair Cleveland Clinic Karl Csaky, MD, PhD “The Role of Retinal Pigment Epithelial Injury in the Development of Geographic Retina Foundation of the Southwest Atrophy” Albert Edwards, MD, PhD “Genetic Insights into the Pathogenesis of AMD” University of Oregon Bela Anand-Apte, PhD, MBBS “Regulation of Choroidal Neovascularization by Tissue Inhibitor of Cleveland Clinic Metalloproteinases-3” Robert Mullins, PhD “The Choriocapillaris in Macular Disease” University of Iowa Health Care 4:00 – 5:30 PM Shuttle Available from UNTHSC to the Courtyard Marriott Downtown 6:00 PM Load Bus at the Courtyard Marriott Downtown for Billy Bob’s Texas 6:30 – 12:00 AM Dinner & Entertainment at Billy Bob’s Texas Including a Live Bull (Buses available to take guests back to the hotel Riding Show & Concert by Miranda Lambert after the dinner at 8:00, 9:00, and 10:00 PM) SUNDAY, FEBRUARY 20 th 7:00 AM – 12:30 PM Shuttle Between the Courtyard Marriott Downtown & UNTHSC 7:30 – 8:15 AM Registration, Exhibits, & Full Breakfast New Developments in Glaucoma Therapy 8:15 – 10:00 AM Daniel Stamer, PhD, Session Chair & Moderator University of Arizona Tomi Luan “TGF-BETA 2 Increases Extracellular Matrix Associated Proteins in Cultured Bovine University of North Texas Health Science Center Trabecular Meshwork Cells” David Woodward, PhD “Rapid Characterization of Functional Prostanoid Receptor Pharmacology in Human Allergan Pharmaceuticals Ocular Anterior Segment Cells by Cellular Dielectric Spectroscopy” Carol Toris, PhD “Day and Night Changes in IOP and Aqueous Humor Dynamics of Patients with University of Nebraska Medical Center Ocular Hypertension Treated with Three Glaucoma Drugs” Ganesh Prasanna, PhD “Effect of PF-04217329 a Pro-drug of a Selective Prostaglandin EP2 Agonist on Alcon Research, Ltd. Intraocular Pressure in Preclinical Models of Glaucoma” Craig Crosson, PhD “Adenosine Analogs as Ocular Hypotensive Agents” University of South Carolina Medical College 10:00 – 10:15 AM Break & Exhibits 10:15 – 12:00 PM Neuroprotection Robert Nickells, PhD, Session Chair “Epigenetic Targets for Preventing Neuronal Cell Loss” University of Wisconsin Adriana Di Polo, PhD “Neuronal and Vascular Protection in Glaucoma: Does Galantamine do the Trick?” University of Montreal Arthur Weber, PhD “Looking Beyond the Eye for Retinal Neuroprotection” Michigan State University Bikash Pattnaik, PhD “Potassium Channels, The Apoptotic Volume Decrease, and Neuroprotection” University of Wisconsin James Randazzo “Evaluation of Orally Active Multi-functional Antioxidants in a Rat Model of Light- University of Nebraska Medical Center Induced Retinal Damage” 12:00 – 12:15 PM Closing Remarks, Evaluations, & Adjourn Not Final Agenda. Schedule Subject to Change.
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