Alternative Use of Silicon Edoardo Charbon TU Delft Alex Dommann - PowerPoint PPT Presentation

Alternative Use of Silicon Edoardo Charbon TU Delft Alex Dommann EMPA Pantelis Georgiou Imperial College London Bruno Murari ST Microelectronics Roland Thewes TU Berlin Chair: Giovanni De Micheli, EPFL

Edoardo Charbon TU Delft

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Alex Dommann EMPA

Pantelis Georgiou Imperial College London

Bio-ins io-inspir pired ed Semiconduct emiconductor ors for or Healt Healthcar hcare e Dr. . Pant antelis elis Geor Georgiou giou (pantelis@imperial.ac.uk) Centre for Bio-inspired Technology, Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering Alt lter erna nativ ive e us uses es of of Silicon ilicon Sympos mposium ium on on Emer merging ging trends ends in in Elect lectronics onics 2 nd nd December ecember 2014 2014

Can we leverage on $1 trillion investment in Microelectronics to create more affordable healthcare? CMOS Opportunities Needs of Modern Healthcare • Scalable • Health services originally • Repeatable designed to manage acute • Low cost illness (i.e. infections and • Miniaturization injury) • System Integration • Today, however 70-78% of • Dedicated performance health budget expenditure is (low noise, low power) on Chronic Disease! Personalised Healthcare • Technology from Hospital to the Home - New Wave Lifestyle • Medical devices towards consumer devices Page 21 21 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

DNA Testing Today Min. 2 weeks Healthcare Application • Point-of-Care Diagnostics • Sequencing Technology SNP Chip of the Future DNA Testing at Imperial: No Lab 15 – 20 mins To read your DNA Source: DNA electronics website (www.DNAe.co.uk) Page 22 22 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

Combined DNA Amplification and Detection in CMOS CMOS is cheap, integration is expensive, how do we break Ion-Sensitive Field this barrier of co-design? Effect Transistor Features • Fully unmodified CMOS • Detect Hydrogen ions using Ion-sensitive Field Effect Transistors. • Can use heating to amplify DNA through PCR (polymerase chain reaction) • Use a reference chamber to do differential measurement and cancel out chemical drift. C.Toumazou, et al.,“Simultaneous dna amplification and detection using a pH-sensing semiconductor system,” Nature methods, 2013. 23 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

Semiconductor DNA sequencing • Moores law has already found its way to DNA sequencing using ISFETs! Source: ion Torrent website (www.iontorrent.com) Page 24 24 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

Whole Genome Sequencing Costs The $100 Genome? • Rapidly reducing costs! • When is Moore enough? • Challenges: • Things difficult to detect at smaller volumes • Noise, mismatch • Reliability of sensors • Micro-fluidic integration • Data Bandwidth • Bio-informatics, Big data How can we scale CMOS sensors and fluidics reliably to exploit Moore? Wetterstrand KA. DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP) Page 25 25 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

Diabetes Current Treatment Glucose measurement Insulin injection Artificial Pancreas • Insulin injection solves the problem Sub-optimal treatment in the short term . • Diabetics still spend a large amount of time in the hyper-glyceamia • Leading cause of blindness, kidney failure, heart disease, neurogenic disease. Page 26 26 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

Can we use a Bio-inspired Approach? Novel Medical Devices Pancreatic Beta Cells Microchips Semiconductor technology Therapy Miniature, Low-power Biology Low-cost The Pancreas Page 27 27 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&