Products TM «BAIKAL legend»….. To live longer …..
� Company “Sibpribor llc” a registered company established in Irkutsk 2008 . � From 2008 to 2013, scientific developments were About company carried out in the field of development of a special technology for obtaining natural extracts. Sibpribor llc � In 2013, the first experimental production of the company's basic products was launched: BioChaga «Baikal legend» and BioDihydroquercetin � In 2014 the products were registered under the –stages of trademark "Baikal Legend" as a dietary supplements in Russia, the first sales started in development pharmacies � Today the company is active both in Russia and in the International markets – Hong Kong, Macau, � Singapore, Serbia, Romania, Slovenia.
� Biochaga and BioDihydroquercetin are obtained from ecologically pure raw materials of the Baikal region. � The natural raw materials collected in Siberia contain the maximum amount of biologically active substances due to the sharply continental climate of our region. � The unique technology (low temperatures and Advantages of deep vacuum) allows to extract biologically active components of natural raw materials as much and our products lossless as possible and preserve their natural form. � Special - super light - the consistency of product (micro-dimension of the particles), ensures their high bioavailability � In the production process, aggressive chemicals and high temperatures are not used � The final product is 100% active substance and does not contain preservatives, dyes and ballast substances
Biochaga and Biodihydroquercetin are natural elixirs of longevity Slow down the aging process at the cellular level � Slow down the development of many serious diseases � associated with aging Cardiovascular diseases � Oncological diseases ❖ Type 2 diabetes mellitus and metabolic syndrome ❖ Alzheimer's disease ❖ Parkinson's disease ❖ Age dementia ❖ And improve the quality of life of the elderly
Biochaga-100% freeze-dried extract of birch mushroom chaga Basic pharmacological actions � Detoxicant (removes toxins, heavy metals and radionuclides) � Antioxidant (bind free radicals) � Immunomodulator and adaptogen (activates nonspecific and T-lymphocyte immune response) � Radioprotector (binds and displays radionuclides � Anti-inflammatory and antispasmodic effect � Cholagogue action � Antibacterial and antiviral action (proven against influenza virus, herpes � Hypoglycemic action � An additional natural source of microelements: especially K and Mg
The chemical composition of the Biochaga extract is unique and conditioned by a special production tech The content of water-soluble components is 92.5 ± 2.3% ❑ The ash content is 7.85 ± 0.31 ❑ Main BAS Chaga: Water-soluble intensely colored polyphenolic pigments (chromogens) 81 ± 2.68% Low molecular weight phenolic compounds (NPS) - 57.00 ± 1.48 mg ❑ / g High molecular weight phenolic compounds (VFS) (melano- ❑ carbohydrate complex) - 24.9 ± 1.2% The content of water-soluble polysaccharides (GRP) - 2.54 ± 0.06% The high content of microelements (especially K, Mg and Mn)
Molecular weight distribution of melanin (gelchromatography method) in Biochaga. The presence of one dominant polymer with a molecular mass of 15 � kDa, which corresponds to early information on water-soluble melanin chaga (Olennikov et al., 2012) The distribution spectrum of melanin polymers: 3,4-dihydroxybenzoic acid (82%); � 3,4-dimethoxybenzoic acid (8%); � 3,5-dimethoxy-4-hydroxybenzoic acid (5%). � 4-methoxybenzoic acid (3%); � 4-hydroxybenzoic acid (2%); � Melanin BioChaga contains mainly fragments of pyrocatechol and pyrogallic types The high content of 3,4-dihydroxy fragments confirms in this melanin a high biological activity
Mechanisms of action of melanin chaga � Effectively suppress the peroxidation of polyunsaturated fatty acids � Geroprotective activity: involved in DNA repair, prevent single-stranded DNA breaks � Protect the body from extreme conditions, exposure to carcinogens and mutagens � Prevent damage to biomembranes and oxidation of glutathione � Depending on the conditions, they can be in the form of phenoxy or semiquinone radicals and interact with oxidation products of xenobiotics and heavy metals � A unique property of melanin pigments is a stable free-radical state and a high content of paramagnetic centers of carboxyl and carbonyl groups.
The main indicators of biological activity and efficiency of Biochaga � High antioxidant activity ORAC 1859 ± 042 µM TE / g ▪ � PROTECTION OF CELL COMPONENTS FROM LIPOPEROXIDATION Hydrophilic protection is high (IC50HYDRO, µg / ml - 32.6 ± 1.1) ▪ Lipophilic - medium - IC50LIPO, mcg / ml - 76.7 ± 3.0 ▪ � High antiradical protection against organic and inorganic radicals Radical O2 • (superoxide radical) - 51.7 µg / ml ▪ Radical OH • (hydroxyl radical) - 82.3 µg / ml. ▪ The radical Cl. (Inorganic natural radical) - 252.16 ± 6.5 meq / g ▪ � A strong reducing agent, similar in activity to ascorbic acid and ionol � Inactivates nitric oxide molecules and has anti-inflammatory properties (nitric oxide binding - (NO) <500 mcg / ml).
INDICATIONS For Taking OF BIOCHAGA � PREVENTION AND AUXILIARY TREATMENT OF ONCOLOGICAL DISEASES � AUXILIARY MEDIUM WITH SUGAR DIABETES (lowers blood glucose level) � AUXILIARY MEDICINE IN THE TREATMENT OF GASTROINTESTINAL TRACT (gastritis, peptic ulcer and duodenal ulcer, dyskinesia of the gallbladder hypomotor type, polyposis of the intestine, constipation) � CARDIOVASCULAR DISEASES AS AN ADDITIONAL SOURCE OF POTASSIUM AND MAGNESIUM � USED AS IMMUNOMODULATOR AND ADAPTOGEN IN DURABLE AND FREQUENTLY AFFECTED PEOPLE � POISONING OF HEAVY METALS � RADIATION INFECTION
Mechanisms of action of chaga in cancer Influences through the central and peripheral nervous system due to the action of � the total complex of BAS (polyphenolic chromogenic complex - melanin, flavonoids, phytolectins). The specific effect of chaga on enzymatic and hematopoietic systems is expressed � in the removal of toxicosis, the restoration of the reactivity of the organism, the normalization of catalase and protease metabolism With prolonged admission, tumor growth slows down and its incidence toward � metastasis decreases Increases the defenses of the body and helps to isolate the tumor tissue, as a foreign body. There are data (MA Krotkina and MP Berezina (1959)) that under the influence of � chaga, a gradual resorption of tumors occurs with the preliminary appearance of micronecrosis and the encapsulation of tumor cells.
Clinical manifestations of the therapeutic effect of chaga in cancer patients � Reduction of tumor intoxication (nausea, vomiting, asthenia) � Improving the quality of life (improves appetite, sleep, tones up � Removal or reduction of pain syndrome � Normalization of the physiological functions of the body � Improves blood picture � Increases life expectancy � The processes of healing of surgical wounds are accelerated
Mechanism of immunomodulating and hypoglycemic activity of chaga Immunomodulator Activation of a nonspecific immune response � Correction of the number of immunoregulatory cells � Normalization of cytotoxic activity of natural killers � and correction of immunodeficiency states HYPOGLYCEMIC ACTION Lectins are capable of reversibly binding carbohydrates in the blood and reducing the sugar content in the blood of diabetic patients (VF Korsun and VM Lakhtin (2004, 2007) Chromium, zinc, manganese - help reduce blood sugar levels
Radioprotective action Chaga (2002 experience on rats) Reduction of the deposition of radionuclides (radioactive isotope strontium (90Sr) in the bone and soft tissues of rats An increase in the excretion of isotopes with urine by 33-35% (LN Rasina � With prolonged gamma irradiation (up to 60 days) of mice, the � cryopreparations of chaga increased the life expectancy of animals by 1.6 times (the control group was 186 days, the group taking chaga-up to 305 days) Chaga prevented the development of leukopenia and promoted the � recovery of red bone marrow cells Chaga inhibited the peroxidation of blood lipids and increased the rate of � recovery of bone marrow cells in animals, which also indicates adaptogenic activity (AS Gavrilov et al., 2003).
The safety of Chaga extract � Chaga is well tolerated � It does not have a toxic and irritating effect � Well combined in therapy with other drugs, including With hormonal. Complete safety in therapeutic doses is confirmed by numerous clinical trials, with continuous long-term use (EY Martynova, PK Bulatov 1961, 1966)
BioDihydroquercetin is a reference natural antioxidant from larch wood BIOFLAVONOID is a natural phenolic compound, a composition of 100% dihydroquercetin
BIODIHYDROQUERCETIN is a standard among antioxidants � Nobel Prize winner Linus Pauling said "... regular taking of dihydroquercetin contributes to a real extension of human life for 20 to 25 years ..." � The antioxidant activity of dihydroquercetin appears even at its concentrations of 0.0001 - 0.00001% with no mutagenic activity for a person.
Main pharmacological properties of BioDihydroquercetin � Antioxidant � Capillaroprotector � Cytoprotector Immunomodulator � Immunomodulator � Improves rheological properties of blood
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