A A New Appr Approach h to to HAI Challenges
Pathogens are a deadly problem 2 million $28 Billion Approximately 2 million patients suffer Direct costs of HAIs with healthcare- ranges: US $28 billion associated infections to 45 billion (HAIs) in the USA. 1 25 90,000 On any given day, about one in 25 Nearly 90,000 are hospital patients has at estimated to die. 1 least one healthcare- associated infection. 2 1: Economic burden of healthcare-associated infections: an American perspective, Patricia W Stone, PhD, FAAN, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827870/ 2: https://www.cdc.gov/hai/surveillance/index.html 2 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
“No clear, superior device/method at this time.” 1 David Weber, M.D., M.P.H., Associate Chief Medical Officer, UNC Hospitals Chemical Heat Physical Antibiotics Conventional Disinfectants (autoclave) (scrubbing) (low-pressure) (bleach, UV chlorahexidine) Labor-intensive, Time-consuming, Labor-intensive, Decreasing Expensive, hot, time-consuming, expensive, not time-consuming, effectiveness, cumbersome, skill-dependent, applicable to skill-dependent expensive, side- disruptive potentially toxic every surface effects 1 As presented at APIC 2018 Minneapolis, MN 3 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
Competitors’ low pressure UV technology Low power: ~32 mW cm 2 Conventional (low-pressure) ULTRAVIOLET VISIBLE INFRARED UV Expensive, hot, cumbersome, disruptive Wavelength (nm) Single wavelength 4 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
A new weapon: High-intensity photonics We are advancing the current state of photonics to improve our ability to inactivate viruses, bacteria and mold. Based on physics (of DNA replication), not chemistry or biology (of cell walls). 5 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
The power of high-intensity photonics Manage multiple wavelengths ULTRAVIOLET VISIBLE INFRARED 222 253.7 365 405 Wavelength (nm) High energy density >1000 mW cm 2 6 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
~ Hyper Light is effective 1.0 E+13 Before PFU - - exposure 1.0 E+12 -- -- 1.0 E+11 -- 1.0 E+10 1.0 E+09 1.0 E+08 1.0 E+07 1.0 E+06 - 1.0 E+05 -- 1.0 E+04 10 3 1.0 E+03 1.0 E+02 1.0 E+01 After exposure 0 0 0 0 2 0 0 - 1.0 E+00 S. Aureus A. brasiliesis P. aeruginosa S. pseudintermedius VRE E. faecalis C. diff* E. coli (e.g., MRSA) (black mold) Exposure 5 sec. 25 sec. 5 sec. 25 sec. 25 sec. 25 sec. 75 sec. 25 sec. EMSL Analytical Laboratory, Research Triangle Park, NC. Data collected 12/2017…6/2018 *Preliminary results, pending final report from Microbac Laboratory, Sterling VA. Data collected 6/2018 18 18 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
Hyper Light is cool 80 Temp. 78 (°F) 76 E. coli VRE 74 E. faecalis S. pseudintermedius 72 A. brasiliensis S. aureus 70 68 66 64 62 60 I I 0 25 100 300 600 Exposure (seconds) EMSL Analytical Laboratory, Research Triangle Park, NC. Data collected 12/2017…6/2018 8 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
The power of Hyper Light • Inactivates pathogens • Fast • Enhances the power, efficacy and usability of UV light • Fits into health care workflows • Superior photonics: Intense, controlled • Superior optics: Precisely focused and amplified • Superior delivery: Precise hand-held delivery • Cool (ambient temperatures) • Patented • Reduces HAIs 9 A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM
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