3D PRINTING AS A MEDICAL INNOVATION PLATFORM 3D PRINTING IN THE - PowerPoint PPT Presentation

3D PRINTING AS A MEDICAL INNOVATION PLATFORM 3D PRINTING IN THE MEDICAL DEVICE INDUSTRY 1 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

OUR SPEAKERS TODAY IMAGE OF IMAGE OF SCOTT HERE MICHAEL HERE SCOTT HANSON MICHAEL GAISFORD TDS DESIGN LAB MANAGER DIRECTOR OF MARKETING, MEDICAL SOLUTIONS MEDTRONIC STRATASYS 2 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

3D PRINTING AT MEDTRONIC: MEDICAL APPLICATIONS AND OUTCOMES PRESENTED BY: SCOTT HANSON TDS DESIGN LAB MANAGER

INTRODUCTION SCOTT HANSON, TDS DESIGN LAB MANAGER TECHNOLOGY AND DEVELOPMENT LAB (A.K.A., “BAT LAB”)

FULL PRODUCT LIFE CYCLE SUPPORT SYSTEM Medical Device Value Chain Technology Development Technology Product Life Cycle Development Lab To Ops Post Special Market Builds Release

BEFORE 3D PRINTING  We did more theoretical thinking  Played with CAD images  Made prototypes from inconsistent combinations of materials  Waited:  4-8 weeks for 1 st iteration molds  3-6 weeks for 2 nd iteration of the mold  3-4 weeks for the final modifications to the mold Developing without 3D Printing Developing WITH 3D Printing Weekly 3 4 5 6 7 8 9 An improvement of 6 – 10 weeks! 6

WHY DID MEDTRONIC INVEST IN 3D PRINTING? Increased Control Low Barriers High ROI to Adoption • • Keep intellectual Much lower per property in-house part cost compared • Already had the • Keep our trade secrets to outsourcing resources/skills • in-house Reasonable • CAD experience • Direct control of part machine cost • Stratasys system delivery timelines ease of use • Develop additive • No special manufacturing expertise material handling in-house Innovation is a core competency in the medtech industry; owning the “innovation e ngine” is integral. 7

3D PRINTING - WHAT ARE WE LOOKING FOR? What was Medtronic looking for?  High part resolution  System versatility – many applications from one system (material selection)  High printing speed  Lab friendly, intuitive and reliable machines  Responsive customer support What Stratasys machines do we use?  Objet 260 TM – initial printer  Objet 500 Connex 3 TM - added  Objet 350 Connex 2 TM - upgrade Objet 260  Stratasys F370 8

3D PRINTING EMBRACED Usage  Stratasys printers used every day  Multiple orders received daily  Multiple departments use us  R&D, PD, Manufacturing, Research, Test Development  Packaging, etc.  Double digit % increases in number of jobs year-over-year 9

3D PRINTING OVER TIME 3D Printed Jobs Completed FY17 FY16 FY15 FY14 Human Factor Anatomical Rapid Concepts New 3D Print Engineering, Modeling Technology Prototyping & Testing Development & Applications Development Test Fixtures Upgraded 260 to Objet 260 Objet 500 Connex Added FDM and Printer the Objet 350, acquired F370 TM 3 acquired acquired Technology Connex 3 10

3D PRINTING DRIVES SIGNIFICANT SAVINGS 3D PRINTING SAVES VS. MACHINING 1 Person # of Jobs Needed Estimated Cost Submitting Jobs to Pay for 3D Total Jobs FY16 of Labor Saved Over 1 Year Printer Jobs 40 250 750 Total Savings $54,000 $340,000 $1,095,000 173 1,080 3,240 (~ 9 years !) Days Saved • Increased usage justifies additional printers • Printers paid for themselves in the first year • On average, 3D printed parts delivered 4.5 days faster 11

HOW STRATASYS 3D PRINTERS HAVE IMPACTED OUR BUSINESS MAKE MORE DECISIONS, FASTER! Medical Device Value Chain • Implement : facilitate • Speed : parts in 1-2 days new technology • Improved customization and integration design : more iterations Technology Development Technology Product Life Cycle Development Lab To Ops Post Special Market Builds Release • Custom : test fixtures • React : respond to that match field issues quickly • Decide : more exact needs • Clinically relevant : decisions, faster recreate human pathology 12

RAPID PROTOTYPING ROBUST DESIGN IN SHORTER TIME Challenges  Final design needed quickly and it is never “perfect” the first time Simulated thermal formed packaging tray  Need to evaluate multiple design configurations  New design requires assembly changes Benefits  Can easily print several iterations to optimize  Can print more than one unit Tweezer concepts  Instruments  Packaging Tiny components of an assembly 13

CUSTOM TECHNOLOGY DEVELOPMENT ADAPT NEW TECHNOLOGY TO UNIQUE REQUIREMENTS Challenges  Needed new special coiling technology to enable new device development  Outside vendor solutions cost prohibitive Benefits  3D print new fixturing to create in-house implementation  Saved 2 months’ project team cost on a 1 year long project  Saved $60K in materials and labor  Durable implementation – still using the 3D printed fixturing 14

BENCH TESTING DEVELOP CUSTOM TEST SET-UPS A. Functional Testing Challenges  Tests need to match the exact specifications of each product  Need to support multiple testing scenarios B. Shipping Testing o Functional Testing o Shipping Testing o Electrical Testing Benefits  FDM Stratasys F370 TM is perfect for building test fixtures  You get the advantages of using the real plastic (ABS, ASA, PLC, etc.)  Customize to exact product test requirements  Fast turnaround  Very affordable compared to C. Electrical outsourced / machine shop Testing  Durable and highly accurate parts 15

PRE-CLINICAL TESTING CLINICALLY RELEVANT ANATOMICAL MODELS Challenges A.  Need bench test equivalence to cadaver models  Animal and cadaver labs are expensive and logistically difficult to schedule B. Benefits  Models match target pathology (based on patient imaging studies) C.  Quickly replicate most challenging clinical scenarios  Replicates soft and hard tissue in one model (multi-material)  Reduces the number of cadavers required o Reserved for final validation effort unless the model is validated as for final design testing D.  Low total cost of testing, shorter development timeline  Educational E. 16

FIELD ISSUE RESOLUTION QUICKLY RETURN PRODUCT TO MARKET Challenges: Benefits:  Resolve problem quickly and get  Qualified the 2 new molds  Launched new design product back on market  Cables require injected molded  Issue was never reported again parts with long lead times and  Speedy resolution expensive processes  Product returned to market 2  Regain customer confidence with months earlier than planned a more robust design  Saved project dollars Prototype Design Issue Tests Final Product 17

3D PRINTING FLOOR LAYOUT AND DISPLAY The Bat Lab  Objet printers are in a dedicated room  Objet cleaners are in a separate room  FDM printer is versatile enough to be placed anywhere in the lab 3D Printing Display • Created for touring internal and external customers • Educates employees 18

IN SUMMARY  Integrate 3D printing into how we bring products to market  Reduce project costs and accelerate time to market  Develop more robust designs

UNLOCK INNOVATION AND ACCELERATE PROCESSES WITH 3D PRINTING 3D PRINTING IN THE MEDICAL DEVICE INDUSTRY MICHAEL GAISFORD DIRECTOR OF MARKETING, STRATASYS HEALTHCARE 20 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

STRATASYS OVERVIEW For more than 25 years, Stratasys has been at the forefront of 3D printing and additive manufacturing innovation. OVER 1,200 GRANTED HEADQUARTERS OR PENDING ADDITIVE EDEN PRAIRIE, MN MANUFACTURING AND REHOVOT, ISRAEL PATENTS GLOBALLY OVER 30 TECHNOLOGY $673 MILLION AND LEADERSHIP REVENUE (2016) AWARDS PUBLICLY TRADED ON NASDAQ (SSYS) 21 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

POLYJET SYSTEMS Multi-texture to combine soft and Full color 3D printing on hard tissue Stratasys J750 3D Printer Quick turn around injection molds High resolution printing to usable with end use materials replicate fine details 22 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

FUSED DEPOSITION MODELING (FDM) • Range of high grade thermoplastics • Durable parts for production part manufacturing • Functionally test prototypes • Biocompatible and sterilizable options 23 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

ECONOMIC AND OUTCOMES 3D printing can reduce costs, improve patient care or increase speed at every step in the medical device value chain. Stratasys solutions enhance economics and outcomes of medical solutions MEDICAL DEVICE VALUE CHAIN MARKETING & RESEARCH & PRECLINICAL LIFECYCLE MANUFACTURING PHYSICIAN CLINICAL DEVELOPMENT TESTING MANAGEMENT EDUCATION FULL RANGE OF REALISTIC PRODUCTION PHYSICIAN PATIENT- RAPID ADDIVITIVE ANATOMICAL PARTS, JIGS AND TRAINING AND SPECIFIC PROTOTYPING MANUFACTURING MODELS FIXTURES SALES AIDS SOLUTIONS USE CASES STRATASYS SOLUTIONS 24 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY

ECONOMIC AND OUTCOMES MEDICAL DEVICE VALUE CHAIN MARKETING & RESEARCH & PRECLINICAL LIFECYCLE MANUFACTURING PHYSICIAN CLINICAL DEVELOPMENT TESTING MANAGEMENT EDUCATION FULL RANGE OF REALISTIC PRODUCTION PHYSICIAN PATIENT- RAPID ADDIVITIVE ANATOMICAL PARTS, JIGS AND TRAINING AND SPECIFIC PROTOTYPING MANUFACTURING MODELS FIXTURES SALES AIDS SOLUTIONS USE CASES STRATASYS SOLUTIONS 25 STRATASYS / THE 3D PRINTING SOLUTIONS COMPANY