2020 Oct 14, 2020 S.U.C.C.E.S.S. Webinar , ND, Dr.TCM Richmond - PowerPoint PPT Presentation

2020 Oct 14, 2020 S.U.C.C.E.S.S. Webinar , ND, Dr.TCM Richmond Alternative Medical Clinic Inc. www.drmartinkwok.com Tel: 604-207-0167

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? ( ) probably reduce influenza in healthy adults from 2.3% without vaccination to 0.9% (risk ratio (RR) 0.41, 95% confidence interval (CI) 0.36 to 0.47 ( ) 2.3% 0.9%, ( ) 59% they probably reduce ILI from 21.5% to 18.1% (RR 0.84, 95% CI 0.75 to 0.95 ( ) 21.5% 18.1%, ( ) 16%

? ( ) Vaccination may lead to a small reduction in the risk of hospitalisation in healthy adults, from 14.7% to 14.1%, but the CI is wide and does not rule out a large benefit (RR 0.96, 95% CI 0.85 to 1.08 ( ) 14.7% 14.1%, ( ) 4%. ( )

? ( ) Vaccines may lead to little or no small reduction in days off work ( 0.04 days, 95% CI 0.14 days to 0.06 , . -0.14 0.06 . Inactivated vaccines cause an increase in fever from 1.5% to 2.3% 1.5% 2.3% ( 53.3% )

? ( ) effectiveness of influenza vaccines against ILI in pregnant women to be 24% (95% CI 11% to 36%, NNV 94), and against influenza in newborns from vaccinated women to be 41% (95% CI 6% to 63%, NNV 27 ( ) 24%. 41%

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? 1. nutritional parameters such as hemoglobin, hematocrit, total protein, iron and vitamin E levels, as well as the DHEA level and the cellular immune response were significantly lower in the nonresponsive group J Gerontol A Biol Sci Med Sci 1999 Feb; 54(2):M59-64. a complete liquid nutrition supplement including enhanced levels of antioxidants may have a beneficial effect on antibody response to influenza vaccination in the elderly population J Gerontol A Biol Sci Med Sci 2002 Sep;57(9):M563-6.

? 2. anti-influenza IgG and IgM were greater in active as compared with moderately active or sedentary participants . J Gerontol A Biol Sci Med Sci 2002 Sep;57(9):M557-62. 3. (probiotics), (prebiotics) -- Vaccine 2009 Sep 18;27(41):5677-84. Drug Des Devel Ther 2018 Jan 25;12:217-230. Nutrients 2017 Nov; 9(11): 1175.

? 4. D3, 1,000-4,000iu -- , -- D<25 nmol/L -- , BMJ 2017;356:i6583 PloS One 2014 Jan 10;9(1):e83553. Viruses 2019 Sep 30;11(10):907. Nutrients 2018 Apr; 10(4): 409. 5. (Zinc) 20mg+ (Selenium) 100ug -- -- Arch Intern Med. 1999;159(7):748 754. Nutr Res 198 8 Jan;8:99-104. Age Ageing 1998 Nov;27(6):715-22.

? 6. -- (Maitake) 6.825 -- (AHCC) 3 Functional Foods in Health and Disease 2017; 7(7):462-482 Nutr Res 2013 Jan;33(1):12-7. 7. -- (chlorella) 400mg 50-55 -- (Fucoidan) 300mg 60 CMAJ 2003 Jul 22;169(2):111-7. J Nutr 2013 Nov; 143(11): 1794 1798.

, , ( ) . COVID Toes? (Acute Respiratory Distress Syndrome, ARDS) 1 .

:50 , 10 : 0 10-39 : 0.2% 60-69 : 3.6% 70-79 : 8% (92% ) 80 : 14.8% (85.2% )

: 56.6%, 41.7%, 33.8%, 11.1%, 9%, 6.9%. 88% , 1/2 4 5700 18 : 0 18-65 : 4.36% (95.64% ) 65 : 16.2% (83.8% ) / : 88.1% Richardson S, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020 Apr 22. doi: 10.1001/jama.2020.6775.

2020, Apr 26 stats https://coronavirus.jhu.edu/data/mortality

/ Sweden NO 5,894 6.0% 578.8 Mexico NO 83,781 10.2% 663.9 Japan NO 1,628 1.8% 12.9 Taiwan NO 7 1.3% 0.3 South Korea NO 433 1.8% 8.4 Canada YES 9,666 5.2% 260.8 UK YES 42,915 7.1% 645.5 France YES 32,601 4.5% 486.7 Germany YES 9,626 2.9% 116.1 Spain YES 32,929 3.8% 704.8 Italy YES 36,166 10.2% 598.5 Belgium YES 10,191 6.3% 892.2 USA YES 214,768 2.8% 656.4 Finland YES 346 2.9% 62.7 Poland YES 3,004 2.4% 79.1 2020, Oct 12 stats https://coronavirus.jhu.edu/data/mortality

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Kluger M. Fever in Ectotherms: Evolutionary Implications. American Zoologist . 1979, 19(1): 295 304. el-Radhi AS, elal. Association of high fever and short bacterial excretion after salmonellosis. Archives of Disease in Childhood 1992; 67: 531-532. Plaisance KI, et al. Effect of antipyretic therapy on the duration of illness in experimental influenza A, Shigella sonnei, and Rickettsia rickettsii infections. Pharmacotherapy. 2000 Dec;20(12):1417-22. Graham NM, et al. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers. J Infect Dis. 1990 Dec;162(6):1277-82. Husseini RH, et al. Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence. J. Infect. Dis. 1982; 145: 520 524. Earn DJ, et al. Population-level effects of suppressing fever. Proc Biol Sci. 2014 Mar 7; 281(1778): 20132570.

Eyers S, et al. The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analyis. J R Soc Med. 2010 Oct 1; 103(10): 403 411. Paul A. Offit, MD. The Case for Letting Fevers Run Their Course. Daily Beast, Oct 15, 2017. (A Professor of pediatrics and director of the Vaccine Education Center at https://www.thedailybeast.com/let-it-burn- why-you-should-let-fevers-run-their-course El-Radhi AS, Barry W. Do antipyretics prevent febrile convulsions? Arch Dis Child 2003; 88: 641-642 Rosenbloom E, et al. Do antipyretics prevent the recurrence of febrile seizures in children? A systematic review of randomized controlled trials and meta-analysis. Eur J Paediatr Neurol. 2013 Nov;17(6):585-8. Murata S, et al. Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode. Pediatrics. 2018 Nov;142(5).

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