1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS 1 CONCEPT - PowerPoint PPT Presentation

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

1 CONCEPT SINGLE TOPICAL PRODUCT

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

Lipophilic phase protects the active principles of the formulations from oxidation. At the same time it has a Hydrophilic phase contains an moisturizing and filming activity, and innovative mixture of TCA, AHA,BHA, contributes to cutaneous hydro- PHA, aminoacids and vitamins. It lipidic film performs a deep biostimulating and revitalizing action, beyond the expected peeling effect

Why the BIPHASIC TECHNOLOGY in BioRePeelCl 3 is important? Who commonly uses TCA medical devices knows very well the negative issues concerning theproducts: Unstable products Darkening Preservation in fridge Oxidation and denaturation

How the BIPHASIC TECHNOLOGY works: • Liphophilic phase floats on hydrophilic phase preventing the contact with the oxygen inside the bottle • The mechanic barrier stabilizes the hydrophilic phase: TCAand other active ingredients does not oxidize • Density difference of the two phases guarantees a constant protection even after shaking

Biphasic formulation advantajes ofBioRePeelCl 3 : Room temperature stability No TCA oxidation No formulation darkening anddegradation Funcionalized liphophilic phase

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

4 FUNCTIONALCOMPLEXES BIO R E P E E L LIPO COMPLEX

GL YCINE Glycine is the most abundant aminoacid in collagen (35%). It hasmoisturizing, antioxidant and regeneratingproperties. PROLINE Basic aminoacid in collagen synthesis and support. It has elasticizing properties so it is indicated for inelastic and aged skin. HYDROXYPROLINE Hydroxyproline is widely present in collagen. It increases and support ceramides synthesis, activating keratinocytes proliferation and fibroblasts’ collagenproduction. VITAMIN C Essential cofactor in collagen synthesis. It is the main cellular antioxidant molecule. It protects from R O S(Reactive Oxygen Species)and regenerate other antioxidant molecules.

Gamma- aminobutyricacid (GABA) It is a non essential aminoacid and the chief inhibitory neurotransmitter in the mammalian central nervous system. It promotes collagen synthesis thanks to inhibition of cutaneous Metalloproteinases (MMPs), cutaneous proteins degradation enzymes 1 . The GABAeffect is cutaneous tissue distension thanks to nerve relaxation and consequent relaxation of the muscles responsible of wrinkling. The result is an effective anti-wrinkle action. 1)Effectsof GABAon the expression of type I collagen gene in normal human dermal fibroblasts. Uehara E 1 , Hokazono H 1 , Sasaki T 2 , Y oshioka H 2 , Matsuo N 2

ARGININE Arginine is a basic aminoacid with moisturizing and trophic functions for the skin. It is involved in blood flow regulation processes. It helps regulating biochemical processes like protein and macromolecule synthesis as collagen, elastin and keratin. Indicated for inelasticskin. It is a biochemical modulator of trichloroacetic acid and the fundamental substrate for NOproduction. It promotes angiogenesis, cutaneous riepithelialization and tissue growth factors production. 2)Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture of skinfibroblasts. Kocic H 1 , Arsic I 2 , Stankovic M 2 , Tiodorovic D 3 , Ciric V 4 , Kocic G 5 . 3)Administration of L-arginine reducesthedelayof the healing processcausedby ibuprofen. Implication of COX and growth factors expression. Sánchez -Fidalgo S 1 , Martín -Lacave I, Illanes M, Bruseghini L, Esteras A, Motilva V.

RIBOFLAVIN Riboflavin, also known as Vitamin B2, is an hydrophilic vitamin, necessary for normal skintropism. It is F AD and FMN precursor, so it is involved in huge number of metabolic reaction, as the activation of other vitamins. It helps removing ROSdue to cutaneous oxidative stress and it canaccelerate cell growth andregeneration. Thedeficiency generates afunctional alteration of the skin with afine-grained and greasyskin 4 . 4) Riboflavin and health: A review of recent humanresearch. Thakur K 1 , T omar SK 1 , Singh AK 2 , Mandal S 1 , Arora S 3

TRICHLOROACETIC ACID It is a carboxylic acid with exfoliating action and indirect revitalizing action. When applied on the skin, it makes epidermal protein precipitate and denaturate; this process is defined keratocoagulation. The level of penetration depends on substance concentration. It performs its action through a three-step biochemical cascade, activating a specific endocrine system of the skin .

Biochemical cascade trichloroacetic acid induced 5: 1)Activation of pre-inflammatory in response tochemical Inflammation acidic stress; IL-1 → IL-10 2) Activation of Skin Stress Response System POMC- induced (proopiomelanocortin); S S R S POMC → MC-1R 3) Growth factor production in response tochemical stress. Proliferation F- α TGF- β1 T G VE G F P DGF 5) Influence of trichloroacetic acid peeling on the skin stressresponsesystem. Kimura A 1 , Kanazawa N, Li HJ, Y onei N, Yamamoto Y , FurukawaF .

LACTOBIONIC ACID This product is made of a molecule of gluconic acid, a poly-hydroxyacid, linked to acarbohydrate,galactose. It is an effective epidermal antiageing molecule and stimulates dermal matrix polymer synthesis and dermal synthesis 6 . It reduces cutaneous Metalloproteinases (MMPs) production, protecting the skin from chronoageing and photoageing 7 . Galactose is an endogen carbohydrate that is used by fibroblasts to synthesize glycosaminoglycans and collagen. 6) Clinical uses of hydroxyacids. Zoe DianaDraelos 7) Lactobionic Acid - a Novel Polyhydroxy Bionic Acid forSkincare. Green AB, Wildnauer HR, EdisonLB

SALICYLICACID It is a beta-hydroxyacids and powerful keratolytic, that selectively cuts keratin aminoacidic chain ofcorneocytes. It doesn’t affect the other dermal proteins, so it exerts the exfoliating action only on dermal protein, making this active principle well tolerated by cells below, void of keratin. It has bacteriostatic and lenitive actions, frees the enlarged pores from the sebaceous content, creating an unfavorable environment for bacterial growth and thus reducing the possibility of formation of acne lesions.

T ART ARICACID It is a dicarboxylic acid and a powerful antioxidant molecule, famous for its lightening and exfoliating properties. It is used for the keratolytic action, it reduce corneocytes adesion. It is effective to treat dry, inelastic skin, acne and blackheads. CITRICACID It is a tricarboxylic acid, with chelating properties for bivalent ions like Ca 2+ ; this is a reason why the acid has antioxidant action. The hydroxyl group in alfa- position of carboxylic group gives exfoliating and keratolytic properties. It also has regenerating and astringent effects for enlargedpores.

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

BIOSTIMULATING ACTION It stimulates fibroblasts' activity and activates PROTECTIVE AND ST ABILIZINGACTIONS cutaneous proliferating and biosynthetic It prevents trichloroacetic acid and other active processes. principles Oxidation, improving performances and product safety. REVIT ALIZING ACTION It increases cellular turnover and production of collagen, elastin and hyaluronic acid. FILMING AND VEHICULA TINGACTIONS It reduces trans-epidermic water evaporation and PEELING AND KERA T OL YTICACTIONS assists active principles vehiculation. It removes outer cells of stratum corneum by breaking corneocytes adesion bonds. REGENERA TINGACTION ANTI-WRINKLE AND ANTIOXIDANTACTIONS It restores and maintains cutaneous hydro-lipidic It reduces fine lines by neutralization of free film. radicals. MOISTURIZINGACTION ANTIACNE – COMEDONES – ENLARGED PORES It increases hydration through direct and indirect It helps battle against acne, it eliminates mechanism. comedones and it has an astringent effect on enlarged pores.

T R E A TMENTS

TCA 35% pHA Lactobionicacid β HA Salicylicacid HA T artaric acid, Citricacid AMINOACIDS Glicine, Proline, Hydroxyproline,Arginine VITAMINS Vitamin C, Vitamin B2 LIFTING ACTIVE PRINCIPLE: GABA LIPOPHILIC PHASE: Squalane, Isopropyl myristate 6 mL x 5 vials

Face - Neck - Decolletè

Face - Neck - Decolletè 7-10 days 7-10 days 7-10 days 7-10 days T0 Tn T3 T1 T2 RECALL PROTOCOL 7-10 days 7-10 days 3 MONTHS 7-10 days Tn T3 T1 T2

TCA 50% pHA Lactobionicacid β HA Salicylicacid HA T artaric acid, Citricacid AMINOACIDS Glicine, Proline, Hydroxyproline,Arginine VITAMINS Vitamin C, Vitamin B2 LIFTING ACTIVE PRINCIPLE: GABA LIPOPHILIC PHASE: Squalane, Isopropyl myristate 12 mL x 3 vials

Hands – Elbows – Glutes – Knees - Feet

Hands – Elbows – Glutes – Knees - Feet 10-15 days 10-15 days 10-15 days 10-15 days T0 Tn T3 T1 T2 RECALL PROTOCOL 10-15 days 10-15 days 3 MONTHS 10-15 days Tn T3 T1 T2

SHAKE AFTER SHAKE BEFORE

ADV ANT AG E S

ASSOCIATIONS KIND OFTREATMENT WHEN INJECTIVETREATMENTS Before PHOTOSTIMULATION Before RADIOFREQUENCY After TOPICALTREATMENT Before

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