ZI VAK TECHNOLOGI ES Multitasker-LC Walk Away UHPLC Analyzer For LC-MS/MS
Clinical Diagnostic Market Roche, Siemens,Midray Sciex, Agilent, Thermo Abbott, Beckman Shimadzu, Waters.. Currrent Clinical Diagnosis Clinical with Diagnostic LC-MS/MS and Market HPLC Immunoassay, Gold Standart ELISA, RIA,FIA Methods WHY ?
2. False positive samples, when the results of the reference assay (LC-MS/MS-total-D) were less than 40 nmol/L but one or more of the immunoassays gave greater than or equal to 40 nmol/L. State-of-the-Art Vitamin D Assays: A Comparison of Automated Immunoassays with Liquid Chromatography–Tandem Mass Spectrometry Methods Christopher-John L. Farrell,1,2 Steven Martin,1 Brett McWhinney,3 Isabella Straub,4 Paul Williams,5 and Markus Herrmann1,4* Clinical Chemistry 58:3 531–542 (2012)
NIST USA Traceability Report for Different Technics for Vit D2-D3 (Zivak 243A and 243B)
Limitations of HPLC and LC-MS/MS For Routine Clinical Use Roche, Siemens,Midray Sciex, Agilent, Thermo Abbott, Beckman Shimadzu, Waters.. Currrent Clinical Diagnosis Clinical with Diagnostic LC-MS/MS and Market HPLC Immunoassay, Gold Standart ELISA, RIA,FIA Methods %95-97 %3-5 FUTURE Ready to Use Analysis Kits Automation and Barcode Reading Walk-away HPLC and LC-MS/MS Analysers
LC-MS/MS vs Immunoassay Advantages Disadvantages Non-Automated Qualified staff required High Specificity The need of rigorous kit validation High Sensitivity Automated Barcode Reading MS/MS methods Lower Kit Costs Direct injection from Vacu tube Multiplexing Measurements Higher maintenance cost (20 K USD / year) High Throughput Higher owner capital cost (200 K USD / device) Automated No need for qualified staff Low Specificity Validated kits Low Sensitivity Immunoassay Affordable prices Higher Kit Costs Better traceability (barcode readers, High Potential for interference Online LIS connection)
LC-MS/MS vs Immunoassay Advantages Disadvantages Non-Automated Qualified staff required The need of rigorous kit validation High Specificity Zivak Multitasker Automated Barcode Reading High Sensitivity Automated LC-MS/MS Direct injection from Vacutube Lower Kit Costs Online LIS connection System Multiplexing Measurements Higher maintenance cost (20 K USD / year) High Throughput Higher owner capital cost (200 K USD / device) Automated No need for qualified staff Low Specificity Validated kits Low Sensitivity Immunoassay Affordable prices Higher Kit Costs Better traceability (barcode High Potential for interference readers, Online LIS connection)
Turn Your LC-MS/MS Instrument into Walk Away Clinical Analyzer Roche, Siemens, Midray Sciex, Agilent, Thermo Abbott, Beckman Shimadzu, Waters.. Currrent Clinical Diagnosis Clinical with Diagnostic LC-MS/MS and Market HPLC Immunoassay, Gold Standart ELISA, RIA,FIA Methods
Zivak Multitasker-LC OUR VISION – Each LC-MS/MS will need an automated sample prep LC Zivak Multitasker Full Automated Sample Preparation and Injection System
Multitasker - LC with TandemGold MS Turkey
Multitasker - LC with Shimadzu 8040 MS India
Multitasker – LC with Sciex 4500 MS Italy
Multitasker - LC with Thermo TSQ MS South Korea
The New HBA1c Analyser HB-100 New Design – 2017 1,5 min analysis time for HbA1c and HbF 6,0 min analysis time for A1c, F, A0, A2, S, C, D, E Variants Real walk-away system with unique modules
Zivak NEW VD-200 D2-D3 Analyser UHPLC System World’s only Walk-Away 25-OH Vitamin D2-D3 UHPLC-UV System – April-2016
HPLC and LC/MS/MS Kits 16
Kit Test Times (sample prep. + run time) Psychoactive Drugs Urine LC-MS/MS Analysis Kit 7 min Amino Acid Biological Fluids LC-MS/MS Analysis Kit 20 min PKU Serum LC-MS/MS Analysis Kit 2 min PKU Dried Blood Spots LC-MS/MS Analysis Kit 2 min Organic Acid Urine LC-MS/MS Analysis Kit 20 min Neonatal Screening Dried Blood Spots LC-MS/MS Analysis Kit 1.5 min Immunosuppressant Whole Blood LC-MS/MS Analysis Kit 2 min VMA HVA 5-HIAA Urine LC-MS/MS Analysis Kit 15 min Catecholamines Urine LC-MS/MS Analysis Kit 16 min Metanephrine Urine LC-MS/MS Analysis Kit 13 min Neurotransmitters in Urine LC-MS/MS Analysis Kit 13 min 25-Hydroxyvitamin D2-D3 Serum LC-MS/MS APCIAnalysis Kit 2 min Total Homocysteine Serum LC-MS/-MS Analysis Kit 2.5 min Hemoglobin A1c Whole Blood HPLC Analysis Kit 1.5 min Hemoglobin Variant Whole Blood HPLC Analysis Kit 6.5 min PKU Serum HPLC Analysis Kit 2 min PKU Dried Blood Spots HPLC Analysis Kit 2 min 25-Hydroxyvitamin D2-D3 Serum HPLC Analysis Kit 6 min Vitamin A-E Serum HPLC Analysis Kit 8 min 25-Hydroxyvitamin D2-D3 Serum VD-200 UHPLC Analysis Kit 3 min
Matrix /IS Labeled Standarts,Controls and Calibrators . 18
Clinical HPLC Analysis Kits HbA1C in Whole Blood • Hb Variant and ß-Thalassemia • 25-OH Vitamin D2/D3 in Serum • Phe, Tyr and Trp in Serum & Plasma and DBS •
Recommend
More recommend
