Undergraduate Summer Research Experience Joel Ducoste, Cranos - - PowerPoint PPT Presentation
Undergraduate Summer Research Experience Joel Ducoste, Cranos Williams, Ron Sederoff, Vincent Chiang NCSU Mark Melton St. Augustine College Objectives Provide summer research experience in Plant Genomics Increase graduate related
– Mr Jamian Smith from St. Augustine’s College, Mr. Ransford Damptey from NC State University. Mr Smith graduated from Engineering
results to literature data
Kinetics for metabolic flux analysis
A representative integrated module in S. cerevisiae
Glucose Activated Transcription factor Hot1 ATPc
Figure (left). Potential patterns for phase portraits that describe the influence of parameters on steady state values Figure (right). The phase portrait to the left shows the relation of ATPn and ADPn, and it’s stability within the metabolic system.
Consider the first four reactions from the upper part of Glycolysis. The image below displays reactions that balance the energy ATP and ADP
Law of Mass Action is applied this system to generate a series of ODEs
A B C
A B B A A B
C
n n n n n n A B
( , ) ( , ) ! C f A B where f A B A and B
Glucose 6-phosphate Fructose 6-phosphate Fructose 1,6-biphosphate
– Mr. Joaquin Green from St. Augustine’s College and Ms. Liya Weldegebriel from NC State University. Mr. Green is a senior in Engineering Mathematics. Ms. Weldegebriel is a junior in Environmental Engineering.
– Steady State Analysis of Regulatory Signaling model – Steady State Analysis of Metabolic flux model – Development and execution of Continuous Boolean Kinetic model – Uncertainty and Sensitivity analysis of Continuous Boolean Kinetic model
NC STATE UNIVERSITY