The Past, Present, and the Future: Department of Pathology and - PowerPoint PPT Presentation

The Past, Present, and the Future: Department of Pathology and Laboratory Medicine Lydia Pleotis Howell MD Professor and Chair Pathology & Laboratory Medicine 1 Department or Presentation Title

My second five-year chair review  A valuable opportunity to: – Reflect – Shine a light – Advocate – Get feedback – Become better than ever 2 Department or Presentation Title

In this presentation, I will share: - Vision and plans from 10 years ago. - Accomplishments today – a few examples among many! - How we have achieved these. - Future directions and plans 3 Department or Presentation Title

10 years ago: Chair Search and Vision Presentation 4 Department or Presentation Title

Vision is important to leadership “Good business leaders: - create a vision, - articulate the vision, - passionately own the vision, - relentlessly drive it to completion.” Jack Welch, former chairman & CEO, General Electric 5 Department or Presentation Title

The chair is the CEO of a major enterprise  Academic pathology is a $120+M business at UCD Health: $8M grants/contracts - $8.2M professional fees - $4.3M purchased services for medical directors - $100+M clin lab revenue - Priceless: Education and community service contributions - 6 Department or Presentation Title

Vision then -- and now To be acknowledged nationally as a department of the future In other words: a department that: Is at the cutting edge of its discipline, anticipates and leads the future thru its research and creative work, prepares others for the distant as well as the immediate future. 7 Department or Presentation Title

Being future-oriented is our inherent obligation: As a land-grant university: - Discover and share knowledge to improve the lives of the people Fits the Chancellor’s vision to “boldly go” This Photo by Unknown Author is licensed under CC BY Fits our role as a core department with a major role in every mission. 8 Department or Presentation Title

If chosen as chair  my duty is to be sure we meet this obligation by: Facilita ting research and discovery: - Future-oriented and multi-disciplinary. Providing clinical care: - Efficient, high-quality, and cutting-edge - Brings innovations to the bedside to the benefit all members of our community. Educating trainees and practitioners: - Emerging methods and trends. - Critical thinking about the future. 9 Department or Presentation Title

Departmental activities/themes: Derived from major forces of change in medicine • Tests for personalized risk assessment, Proteomics and other prevention strategies, treatment, monitoring. Biomarkers • Digital and in-vivo imaging on gross and sub- New imaging technologies anatomic and cellular level • Quantitative image analysis • Integration of clinical and research info Informatics and AI • Data-mining • Availability across wide geographic areas • High quality, innovative, efficient care Healthcare economics & • New delivery sites: POC, home reform • Diminishing workforce, growing needs 10 Department or Presentation Title

The national context: NIH priorities Example: NCI’s 2010 Professional Judgment Budget Request - Clinical proteomics & other resources: $75M - New imaging tools: $150M - Biomedical computation: $45M - Oncology tissue banks: $30M - CaBIG & BIG network: $100M 11 Department or Presentation Title

NCI Budget Proposal 2021  Many similar themes today  Opportunities specifically noted in the report: – Microbiome – Artificial intelligence – often combined with imaging – Implementation science 12 Department or Presentation Title

The national context, con’t  CAP’s 2010 Campaign to Transform Pathology includes: – Investigation in emerging technologies – Better integration across disciplines: laboratory, clinical & basic science – New best practices & standards – Education not just for now, but for the future, too. 13 Department or Presentation Title

Fits my own experience • My leadership in American Society of Cytopathology and their focus on the future: • Vice president (at that time – later president) • Past-president, ASC Foundation • Executive Board member x 5 years in 2010 – 10 years total. • Discussion facilitator at ‘09 ASC Future Summit 14 Department or Presentation Title

Focus on innovation is especially important for today’s leaders 15 Department or Presentation Title

Have we achieved the vision? Are we an innovative and future-oriented department? 16 Department or Presentation Title

Research accomplishments: Discovery of new knowledge drives innovation  improve clinical care 17 Department or Presentation Title

NIH funding and rankings NIH Funding and Ranking, 2010-present  NIH funding: UCD Dept. of Pathology & Laboratory Medicine – $4.2M as of July 2019 $6.00 80 – Higher today 70 $5.00 60 $4.00 50  NIH rankings: $3.00 40 – #68 in 2011  #42 in 2018 30 $2.00 – Mid-30s predicted for 2019 20 $1.00 10 $0.00 0 NIH Funding, Dept. of Pathology & Lab Medicine Ranking, Pathology & Laboratory Medicine 18 Department or Presentation Title

Areas of strength  Neuroscience group: $16+M in NIH grants over past 5 yrs.  Vice Chair of Research Yvonne Wan: – Top 15 funded PIs at UCD School of Medicine – $7.5M total awards in the past 5 yrs.,  Anticipate more growth – New research-intensive faculty recruitments in progress. – On-going work by our current faculty 19 Department or Presentation Title

Not all about rankings: We are acknowledged leaders of major multi-disciplinary programs  Multi-center personalized medicine studies: NIH-funded All of Us and WISDOM – Site PI: Sandy Borowsky MD  Neuropath Core, $13M NIH R01 “Oldest Old” Dementia study – Lee-Way Jin MD PhD  Microbiome Program, Cancer Center – Led by Yvonne Wan PhD – Recent collaborative seed grant program  Clinical trials, largest site for Roche Diagnostics – Nam Tran PhD 20 Department or Presentation Title

New technology: Cool new tools for pathologists  Imaging: MUSE (Levenson/Fereidouni) – Involved lots of faculty and students  Awards – Astellas C3 Technology award – Chancellor’s Innovation Award – Innovation of the Year, Optical Society – 2019 Power List, The Pathologist  Validation as a lab-developed test is underway 21 Department or Presentation Title

More cool tools – James Chan and colleagues 22 Department or Presentation Title

Even more cool new tools: Artificial intelligence  Artificial intelligence/Machine Learning – Rashidi – Graff – Dugger 23 Department or Presentation Title

Our research role is not just about us : - We support research across UCD Health 24 Department or Presentation Title

Leaders of inter-disciplinary seed grants • Inter-dept seed grant program  Pathology. 2015- 2016 • Expanded from 4 to 8 departments: $80,000 2016- • Pathology leadership continued 2017 • Expanded from 8  16 departments: $160,000 • Collaborative for Dx Innovation: $370,000 2017- • Gift + 11 depts, 3 Centers, SVM, PMB, OOR 2018 • 9 Pathology faculty involved in 10/17 projects 25 Department or Presentation Title

Support research in the clinical lab Clinical Research Oversight Committee  Purpose: – Create an effective “front door” to foster research in our clinical laboratory. – Ensure: - Capacity (instrumentation and staff) - Workflows to protect turnaround time of clinical work - Appropriate pre-analytic specimen preparation - Compliance with CAP and other regulations - Payment for services rendered – Minimize tension and conflict.  Outcomes (as of 12/2018) – 223 projects supported – Serves 108 principle investigators and 30 departments. – Improved satisfaction and attitude among clinical investigators and lab staff. 26 Department or Presentation Title

Education accomplishments 27 Department or Presentation Title

Educational breadth spanning the professions and level of learners Clinical Continuing Medical Residents Lab Medical Undergrad Education Laboratory Scientists programs for students Fellows Technician Practitioners Cytotechs 28 Department or Presentation Title

New in education over the past 5 years  2 nd year med student course (PMD410): – #1 rating in pre-clinical curriculum:  New electives for med students: – 3 rd yr elective – Acting internship in AP – Increased capacity for 4 th electives  New lab professional training: – Med Lab Tech – Cytotech – award-winning grads!!!  Clinical Informatics Fellowship 29 Department or Presentation Title

Highlight: Two educational programs 30 Department or Presentation Title

Residency program  High ratings in ACGME annual survey  Above nat’l average in recent engagement survey  Thanks to hard work by many after an external review. 31 Department or Presentation Title

Award-winning residents  George Gao – Best poster, USCAP – Two leadership awards: ASCP, USCAP  Ying Liu – Certificate of Congressional Recognition for volunteerism with ACS  Ananya Datta Mitra – UCDH High Value Care Competition 32 Department or Presentation Title