CEA - A research body mainly devoted to technology mainly devoted to technology Defense Defense Energy Technologies for Information and Health and Health Life Science Division 1
The CEA Nuc uclear En Energy Life Science Division Five operational divisions Five operational divisions Five transverse programs Five transverse programs Military ry applica lication Techno nologica cal res. Mater terial Scie ciences Life Scien Li iences 2
Pionner: F.Joliot General presentation General presentation General presentation General presentation The Life Sciences Division The Life Sciences Division Life Science Division 3
The Life Sciences Division (DSV) Resources for Research (2006): Resources for Research (2006): Total: 1890 researchers Post-docs and technical staff in 2006 and technical staff in 2006 CEA CEA 151 PhD students 299 + 230 people in 2007 1050 (Genoscope and CNG) (Genoscope and CNG) Budget for Life Sciences: 390 Other Agencies 180 M€ (including 50 M€ 180 M€ (including 50 M€ external resource) Organization and programs: Research programs � Radiobiology � Environmental nuclear Toxicology � Nuclear medicine 8 institutes � Labelling, structure and engineering of Biomolecules � Genomics and large scale biology � Biotechnologies � Biotechnologies � Security : nuclear, radiological, biological and chemical risks Life Science Division 4
The Life Sciences Division (DSV) National organization National organization Division of Life Sciences Director : Gilles Bloch Fontenay-aux-Roses centre Malgorzata Tkatchenko Institute of biology technologies Saclay (IBITEC-S) Saclay (IBITEC-S) Michel Riva Institute of molecular and cellular radiation biology (IRCM) Institute of life sciences research and Paul-Henri Roméo Paul-Henri Roméo technologies (IRTSV) technologies (IRTSV) Jérome Garin Institute of emerging diseases and innovative therapy (IMETI) Jean-Pierre Ebel Institute of structural Philippe Leboulch Philippe Leboulch biology (IBS) Eva Pebay-Peyroula Institute of biological imaging (I²BM) Malgorzata Tkatchenko Malgorzata Tkatchenko Institute of environmental biology and Institute of environmental biology and biotechnology (IBEB) Thierry Heulin Institute of genomic (IG) Jean Weissenbach Jean Weissenbach Life Science Division 5
The Life Sciences Division (DSV) Staff distribution: Caen Fontenay-aux-Roses : 20% Saclay - Orsay : 35% Evry : 11% Evry : 11% Grenoble : 14% Cadarache : 12% hôp. St-Louis hôp. St-Louis CEA Fontenay CEA Grenoble Jouy-en-Josas CEA Saclay CEA Saclay SHFJ Orsay SHFJ Orsay CEA Marcoule CEA Cadarache Évry CEA DIF Life Science Division 6
The Life Sciences Division (DSV) Technological facilities (in addition to genomics facilities) Technological facilities (in addition to genomics facilities) Infrastructures for In vivo imaging Biochemistry for research on Prion research on Prion post-genomics platforms disease Screening facilities Screening facilities Structural Structural Platforms for Platforms for for bioactive Biology Platforms biochips molecules Infrastructures for research in radiobiology and nuclear toxicology Proteomics Platform for Technological Platform Phytotechnology Life Science Division 7
The Life Sciences Division (DSV) 3 missions in line with the general strategy of CEA 3 missions in line with the general strategy of CEA � Biological bases of a sustainable nuclear option • The scientific nature of medical and environmental risks • The scientific nature of medical and environmental risks (radiobiology, environmental toxicology) • Answer to public and political issues (e.g. low doses) Energy Energy • Select and prepare experts for international agencies • Select and prepare experts for international agencies � Provide the health sector with technologies An original set of competences and facilities An original set of competences and facilities • In vivo imaging and innovative labelling • Biotechnologies • Structural biology and protein engineering • Structural biology and protein engineering Technologies for health Technologies for health • Computing, bioinformatics � Knowledge and tools for biosecurity & biodefense � Knowledge and tools for biosecurity & biodefense • Emerging diseases (prion, virology) • Bioterrorism (toxins, infectious agents) Global security Global security Life Science Division 8
Energy The Life Sciences Division (DSV) Bio for safe nuclear energy Bio for safe nuclear energy Nuclear Radiobiology Radiobiology toxicology toxicology Effects of ionizing radiations � Entry routes in the biosphere � Entry routes in the biosphere • Characterization of biological responses • Characterization of biological responses and human (from micro-organisms (molecular damages, cell and tissue response, cancerogenesis) to plants and humans) • Specific markers of exposure and response • Specific markers of exposure and response � Mechanisms of toxicity � Mechanisms of toxicity • Markers of individual susceptibility (radiological and/or chemical) • Effects on germinal cells � Quantification of impact to human health Radioprotection � Novel protection measures Life Science Division 9
Technologies for health The Life Sciences Division (DSV) Medical imaging Medical imaging • Methodologies : TEP, MRI, multimodal animal imaging • Imaging of cognitive processes (language, memory, calculation, …) • Nuclear medicine: neurodegenerative diseases, psychiatry, oncology, cardiology • Imaging gene expression (gene and cell therapy) • Drug discovery and development • Drug discovery and development • Image analysis Biomolecules : Labelling, structure and engineering Biomolecules : Labelling, structure and engineering • Novel labelling concepts and methods • Structure and function of biomolecules • Structure and function of biomolecules • Protein engineering Biotechnologies Biotechnologies • Diagnostics and medical monitoring • Diagnostics and medical monitoring Methods for pharmacology and pharmacokinetics, biomarkers, assays for food and environmental safety • Biochips • Biochips • Bioenergy : bioinspired and biomass Life Science Division 10
Security The Life Sciences Division (DSV) Mobilization against CRBN threats Mobilization against CRBN threats � Biomolecular technologies � Knowledge of biological agents, dedicated facilities � Microelectronics, sensors � Microelectronics, sensors • Characterization of current and potential threats (toxins, virulence factors, genomes, antigens…) • Novel detection assays • Novel detection assays • Medical protection (vaccines) • Medical treatment (HTS of drug leads, structure- based drug design) • Decontamination (enzyme-based processes) Life Science Division 11
Genomics The Life Sciences Division (DSV) In 2007 integration to the Life Sciences Division of the CEA: In 2007 integration to the Life Sciences Division of the CEA: • Genoscope - French National Sequencing Centre (CNS) • French National Genotyping Centre (CNG) In association with an array of post-genomic platforms (manufacturing DNA chips, high speed screening, proteomic analysis, functional and structural studies, etc.) Service to the scientific community + specific research projects + specific research projects Complementary competences for innovation � High-throughput technologies development and bioinformatics applications � Individual susceptibilities in radiobiology and toxicology � Personalized medicine � Personalized medicine Life Science Division 12
The Life Sciences Division (DSV) Web site: Web site: http://www-dsv.cea.fr Life Science Division 13
The Life Sciences Division (DSV) Platforms Life Science Division 14
The Life Sciences Division (DSV) A unique research platform brain imaging with very A unique research platform brain imaging with very high field NMR � Development of new concepts and designs for very high field MRI field MRI design of a large bore, 11.7 T magnet for human studies � Development of new methods and concepts in Development of new methods and concepts in 4 very high fields magnets: data/image analysis and neuronal modeling for the 17T mouse, 3T human, 7T cognitive sciences human, 11.7T human � High resolution anatomical and functional MRI in humans, from newborns to adults � Neurophysiology (electrophysiology) and neurochemistry in Neurophysiology (electrophysiology) and neurochemistry in non human primates using very high field MR imaging and spectroscopy � Microscopic imaging of brain development and functional genomics of transgenic mice Life Science Division 15
The Life Sciences Division (DSV) A pre-clinical imaging facility for gene and cell therapy A pre-clinical imaging facility for gene and cell therapy New facility under construction in Fontenay � (CEA) in collaboration with Inserm (primates, animal (CEA) in collaboration with Inserm (primates, animal PET, MRI, MRS) Development of innovative therapies for � neurodegenerative diseases including ex vivo and in vivo gene therapy Avant Development of primate models for human diseases � Pre-clinical trials in surgery � Development of technologies and assays Development of technologies and assays � � for imaging molecular/cellular events in living animals (MRI, MRS, PET) especially for therapeutic monitoring and especially for therapeutic monitoring and analyzing in vivo gene expression Life Science Division 16
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