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RX-10 Enhance Your Jacketed Lab Reactor Beat Dietrich October 2015 - PowerPoint PPT Presentation

Dec 12, 2022 •855 likes •1.21k views

RX-10 Enhance Your Jacketed Lab Reactor Beat Dietrich October 2015 Content Jacketed Lab Reactor (JLR) Challenges RX-10 Overview Voice of the Customer 1 What is a JLR System? Stirrer PAT Probe Temperature Jacketed Lab Reactor 2

  1. RX-10 Enhance Your Jacketed Lab Reactor Beat Dietrich October 2015

  2. Content  Jacketed Lab Reactor (JLR) Challenges  RX-10 Overview  Voice of the Customer 1

  3. What is a JLR System? Stirrer PAT Probe Temperature Jacketed Lab Reactor 2

  4. Challenges with Traditional Lab Reactors Inconsistent Manual Parameter Lost or Missing Data Manual Controls Control Failing to Document Documentation Means time- Scientists must be in Leads to Repeat and Reporting consuming task of lab to change process Experiments Time Consuming relearning controls parameters and Error Prone Lack of integration Inefficient use of Increase waste of Bottlenecks post Increases risk of resources and materials and time experiment delay inconsistent results limited ability to run timely decisions safe overnight experiments 3

  5. Challenge 1: Inconsistent Controls  Many different interfaces for thermostats. Not easy to use.  If Control Software is Available, a Trained (Dedicated) User is Required to Operate it  Difficult To Find Replacement People To Run Experiments Multiple Interfaces Increases Risk of Error 4

  6. Solution 1: One Simple, Standard Interface One Simple, Standard Interface Integrated Control for all Equipment - Instantly intuitive  No training required - Single point of control for major process parameters (dosing, temperature, stirring)  No need to learn multiple interfaces 5

  7. Challenge 2: Manual Parameter Control Sample Method Stir at 250 rpm Heat to 70 °C Take Sample Dose 200 g Chiller failure Wait Wait Wait Readjust parameters Safety Productivity Behavior in case of an How to avoid going back to the unexpected event? lab for every activity? Lack Control over Scheduling and Process Safety 6

  8. Solution 2: Unattended 24/7  Pre-program Tasks on Touchscreen or in iControl - Automated parameter control means experiments can be run overnight - Experiments can be quickly repeated  Program Safety Limits - Ensures safe unattended operation even with an equipment failure Program Sequences for Unattended 24/7 Safe Operation 7

  9. Challenge 3: Lost or Missing Data  Each instrument produces different data that may not be logged or stored Stirring  Lack of integration makes analysis difficult pH Temperature Lost Productivity Slows the Pace of Process Optimization 8

  10. Solution 3: 100 % Data Capture  Live reaction data trended on touchscreen or PC  Improve experiment documentation and process knowledge  Quickly repeat experiments based on previously captured data 100 % Data Capture to Understand and Optimize 9

  11. Example Reactor Temp Response to Dosing  Quickly Observe Process Data as it Responds to Reaction Conditions As Dosing Begins, Exotherm is Observed Vr (mL) Temperature °C Volume (mL) Tr (°C) Time (h) 10

  12. Solution 3: 100 % Data Capture For Advanced Analysis Using iControl Software:  Overlap all reaction parameters with dosing trends and process analytical data for a full understanding of the process Understand Reaction Kinetics to Improve Process Design 11

  13. Example Detecting Temp. at Nucleation  Link Process Temperature to ParticleTrack Data to Measure the Temperature at the Onset of Crystallization # of particles <50 microns Measure Temperature Detect Nucleation Temperature °C Overlap and Identify Process Conditions at Events 12

  14. Challenge 4: Documentation and Reporting Real Extract from Lab Journal Personal Document, not backed up or shared Data is not digital (information is not searchable) Captured in local language (reuse of knowledge limited to local team) No stirrer speed, temperature or set point documented (poor reproducibility)  Complete Documentation (Description of Equipment and Recipe) is Difficult and Very Time Consuming Resulting in Lost or Inaccurate Information Poor Reproducibility and Limited Knowledge Sharing 13

  15. Solution 4: Powerful Reporting  One-click MS Word/Excel report documenting the recipe and equipment.  Drag and drop designer creates flexible reports with custom trend graphs Generate accurate history for effective communication 14

  16. Solution Overview with RX-10 One Simple, Unattended 24/7 Powerful 100 % Data Standard Interface Reporting Capture An integrated Sequences of Record complete and Quickly prepare controller for all automated parameter accurate process data reports for accurate process chemistry controls means for improved history and equipment increases experiments can be experiment effective accessibility and run safely overnight documentation and communicaiton consistency process knowledge 15

  17. Content  Jacketed Lab Reactor (JLR) Challenges  RX-10 Overview  Voice of the Customer 16

  18. RX-10 Overview SmartConnect ™ Third party sensors such as: Sensor Port • Reflux temperature • Mass flow meter • Pressure sensors RS232 Network iControl / iC DC PC-based recipe control and data Tr analysis with PAT integration Accessories • Automated Dosing • Additional sensors • Sampling RX-10 Base Unit Peripherals Existing Jacketed Touchscreen Operation Lab Reactor 17

  19. RX-10 at a Glance SmartConnect ™ sensor port USB ports Plug & play of Pt100, Data Export voltage and current sensors Firmware Upgrades Ethernet (Network) iControl / iC Data Center CAN accessories Plug & play connectivity Touchscreen port to DU-SP50, EasySampler, 1 m or 3 m cable length ECB, etc. Thermostat/Stirrer Easy-to-use touchscreen RS232 port, plug & play Basic functions learned recognition of equipment within 60 seconds Safety relay Acoustic or visual alerts Emergency button To trigger emergency program 18

  20. SmartConnect™ Cable SmartConnect Cable - Smart chip technology automatically recognizes standard laboratory instrumentation for immediate control and data collection  No need for added adaptors or specialized setup time/cost  Moving instrumentation from one vessel to another is fast and easy - Connects to:  PT100 (Temperature)  Pressure sensors, Mass Flow Meters  Any Other Analog Sensor with Voltage or Current Output

  21. RX-10: Technical Specification Huber, Julabo – all models with RS232 port. Thermostats IKA, Heidolph, J-KEM – all models with RS232 port Stirrers Temperature Range Full range supported by Huber or Julabo thermostats (-120 °C – 425 °C) Volume range / Reactors Choose what is best for your application. There are no volume or reactor limits given by RX-10. SmartConnect TM Port Pt100 4 wires (RTD) (plug & play) Voltage -10 V to +10 V Current 0 to 20mA Connectivity and data transfer Ethernet: Communication to PC (iControl/iC Data Center) CAN: Interface for peripherals (ECB, DU-SP50, EasySampler) USB: Data Export to USB stick Supported languages English, German, French, Spanish, Japanese, Chinese - Safety features Emergency button for immediate execution of emergency program - Emergency relay to connect audible or visual alert 70 mm x 152 mm x 215 mm (2.75” x 5.98” x 8.46”) Dimensions, W x D x H Weight 2,88 kg, including touchscreen 20

  22. RX-10: Delivery Scope 30208790: 30217050: RX-10 with RX-10 with 1m touch- 3m touch- screen screen cable cable 1 RX-10 main unit 1 1 Touchscreen 7’’ 2 1 (1m cable) Touchscreen 7’’ 3 1 (3m cable) 4 Power Supply 1 1 5 Lab Bar Holder 1 1 Thermostat/Stirrer 6 1 1 RS232 cables USB memory stick 7 1 1 2GB 8 iControl DVD 1 1 9 iControl Office License 1 1 RX-10 Quick Start 10 1 1 Guide 21

  23. Synthesis and Process Development Tools EasyMax and OptiMax are Turn Key Development Workstations  All-in-one System / Minimal Footprint  Reactors are Easy to Change and Easy to Clean  No Need For External Thermostat  Ready-to-Go Reactor Setups  Fast And Stable Temperature Control  Easily Upgrade To Calorimeter EasyMax 102 1 ml – 400 ml EasyMax 402 100 ml – 400 ml OptiMax 250 ml – 1000 ml 22

  24. Feature Comparison EasyMax / # Feature Standalone JLR RX-10 RC1e OptiMax     1 All-in-one system / minimal footprint     2 Reactor easy to change/clean     3 No need for external thermostat Ready to go reactor setups     4 for distillations, pressure, ..     5 Touchscreen to control ALL process params     * 6 iControl     7 iC Data Center     8 PAT data integration     9 UCB Universal Control Box (RS485) – PC only     10 EasySampler integration     11 ECB Easy Control Box (CAN plug'n'play)     12 DU-SP50 Dosing Unit (syringe pump)     13 Upgradable to calorimeter     14 RTCal     15 Adiabatic mode   16 Real Tj measurement not T bath of chiller - -     17 Tr-Tj control for distillations / reflux     18 Non-linear ramps for crystallizations     19 Fast and stable T control     20 One-click report * = iControl recipe exchange possible between RX-10, EM and OM but not with RC1e. iControl for RC1e is a different application. 23

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