RNAi Triggers for Agriculture RNA on target
What we do and why NanoSUR develops proprietary, potent RNA materials that selectively target pests in a crop and produce a yield improvement at lower treatment costs Without modifying the crop’s genome, our improved stability and delivery enables the widespread use of RNAi triggers in large-scale agricultural applications 2
About NanoSUR NanoSUR originated with a group of world-class biology Mia iami Madison and chemistry experts in all things RNAi who realized that Agriculture applications could be scaled up by addressing RNA delivery to its targets
Team Members G. ARHANCET Ph.D. D. ROZEMA Ph.D. J. ARHANCET Ph.D. D. LEWIS Ph.D. A. FEHRETDINOV VP-Chemistry CEO President CSO CFO C. HUCK V. TRUBETSKOY Ph.D. K. KOGEL Ph.D. I. GATTI Ph.D. ADVISOR, Phytopathology DIRECTOR, Bus. Dev. DIRECTOR, Formulation ADVISOR, Regulatory 4
Market Opportunity Crop Protection • Dia Diamondback moth ,$1.3 billion/year, globally Aquaculture • Soybean aphid , $2.4 billion/year, USA • White spot syndrome virus of shri rimp, >$0.9 billion/yr • Red imported fire ant , $1.2 billion/year, globally • Sea lice of salmon , >$0.5 billion/yr • Fusarium head blight of wheat & barley, $0.84 billion/year, USA • Gibberella corn stalk and ear rots, $0.38 billion/year, USA 5
Business Model & Fin inancing Licensing Product Development • by sequence $225K (2017-2018) • NSF Phase I for POC by pest/parasite • by host • by geography $750K (2019-2021) NSF Phase II for DBM or Exit by acquisition $....K (2019-2020) Other Phase I Opportunities from NSF & USDA for FG & RIFA, PA 6
Chall llenges of Curr rrent Envir ironmental RNAi Current RNAi triggers are efficacious on a limited number of targets Current RNAi triggers have limited stability and inefficient delivery This results in extremely high concentrations needed to control pests in the field • High cost of applications • Potential loss of selectivity
NanoSUR’s solution: Modified dsRNA (MdsRNA) Low cost dsRNA NanoSUR’s Knowledge base on NanoSUR’s MdsRNAs chemically modified RNA process POC achieved: MdsRNAs show high biological activity IP estate covers • compositions of matter • methods of manufacture • methods of use & formulations First application allowed (Number 15/803,948, USPTO) 8
AGRICULTURE V alue Proposition & Competition Improved crop yields & lower costs to control pests, through higher efficacy & selectivity, and better pesticide resistance management than attained using current pesticides in the market We don’t modify the crop’s genome NanoSUR’s PRODUCTS CHEMICAL PIP (TRANSGENIC) BIOPESTICIDES - ++ ++ + Market size -- - - + Pest resistance costs - - + ++ Time to market -- ++ + + Off-target effects
In summary … NanoSUR brings a Proprietary Platform for RNAi Applications in Agriculture • Cost-effective and scalable methods to produce MdsRNAs • Designed to improve deliverability and stability • Properties of each of NanoSUR’s MdsRNAs can be can be tailored to target each type of pest/application Proof of concept achieved in a fungus and insects from three orders, with additional targets planned 10
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