Recenti TOPIC-ISSUES dalla letteratura non-BR BR-ONJ DR. PAOLO G. - PowerPoint PPT Presentation

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Recenti TOPIC-ISSUES dalla letteratura non-BR BR-ONJ DR. PAOLO G. ARDUINO, DDS, MSC, PHD SCUOLA DI MEDICINA DIPARTIMENTO DI SCIENZE CHIRURGICHE UNIVERSITA DEGLI STUDI DI TORINO CIR DENTAL SCHOOL Jaw osteonecrosis. . When did it it

Recenti TOPIC-ISSUES dalla letteratura non-BR BR-ONJ DR. PAOLO G. ARDUINO, DDS, MSC, PHD SCUOLA DI MEDICINA – DIPARTIMENTO DI SCIENZE CHIRURGICHE UNIVERSITA’ DEGLI STUDI DI TORINO – CIR DENTAL SCHOOL
Jaw osteonecrosis. . When did it it start?
BRONJ 2003
BRONJ 2003
Bisphosphonates-related Osteonecrosis of the Jaw
MRONJ 2014
Medication-related Osteonecrosis of the Jaw
MRONJ _ definition
MRONJ (medication?)
MRONJ (medication?)
2014  2018 1. 1. LITERATURE REVIEW (non-BR-ONJ)
2014-2018 (march)
2014-2018 (march)
2014-2018 (march)
2014-2018 (march)
2014-2018 (march)
2014-2018 (21st of April) - Denosumab - Rituximab - Bevacizumab - Imatinib - Sunitinib - Adalimumab - Aflibercept - Regorafenib - Axitinib - Sorafenib - Everolimus - Ipilimumab - Methotrexate - Cabozantinib - Imatinib - Romosozumab - Raloxifene - Infliximab - Erlotinib - Dasatinib
2014-2018 Rituximab  a.CD20 - De Denosu sumab - Bevacizumab  a.a.g. Imatinib  i.RTK - - Sunitinib  i.RTK Adalimumab  a.TNF - - Aflibercept  a.a.g. Regorafenib  i.RTK - - Axitinib  i.RTK Sorafenib  a.FAK - - Everolimus  i.mTOR Ipilimumab  anti-CTLA-4 - - Methotrexate  i.s. Cabozantinib  i.RTK - - Imatinib  i.RTK Romosozumab  s.m.a. - - Raloxifene  SERMs Regorafenib  a.a.g. - - Infliximab  a.TNF - Erlotinib  i.RTK - Dasatinib  i.RTK -
MRONJ _ incidence
MRONJ _ incidence
non-BR BR-ONJ _ incidence worldwide
non-BR BR-ONJ _ incidence - 1 case per 666 cancer patients treated - 1 case per 10.000 osteoporotic patients
non-BR BR-ONJ _ incidence Piedmont
non-BR BR-ONJ _ difference with BRONJ?
non-BR BR-ONJ _ difference with BRONJ? - No difference in comorbidities
non-BR BR-ONJ _ difference with BRONJ? - No clinical differences
non-BR BR-ONJ _ difference with BRONJ? - No radiological differences
non-BR BR-ONJ _ difference with BRONJ?
non-BR BR-ONJ _ difference with BRONJ? - Prevention differences?
non-BR BR-ONJ _ difference with BRONJ?
non-BR BR-ONJ _ difference with BRONJ?
non-BR BR-ONJ _ difference with BRONJ? - Outcome differences?
non-BR BR-ONJ _ Take home message
non-BR BR-ONJ _ Take home message - Denosumab, bevacizumab, sunitinib - < incidence - Probably differences in the duration of therapy (no dose cumulative) - Probably better surgical outcome (no data on medical one) Difficulties in the correct classification (  ) and nomenclature - - New other drugs ? …. incoming

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