Presentation to VRIC: Global Genomics & Bioinformatics Research Institute (GGBRI) May 24, 2017
Agenda • Global Genomics & Bioinformatics Research Institute (GGBRI) • Capital Request • Recruitment Request 2
GGBRI Overview
Virginia as a Global Clinical Life Sciences, Commercial Services Life Science Translational Research & Companies Research Commercialization Leader Entrepreneurs Biomedical Venture Sciences Capital + University Research Accelerators and Commercial Partners Engineering: Computational Biomedical, Science Mechanical, Bioinformatics Materials Big Data Sequencing 4
GGBRI Strategic Objectives • Improve the health of all Virginians • Form collaborative partnerships that fully leverage and integrate, rather than duplicate, the strengths of Virginia’s health, research, and scientific assets from Virginia’s research universities and the commercial sector • Partner with NSF, DOD, NIH and other research sponsors to leverage new research and innovation to drive regional and statewide economic development • Attract the world’s most outstanding eminent research scientists to Virginia as part of a globally leading life science and research ecosystem • Leverage new scientific discoveries and intellectual property into new drugs, devices, and novel therapies 5
ICPH Campus A Clinic A B C B Cancer Institute D C Research - GGBRI D Technology E E Conference Center 6
Strategy and Focus • GGBRI Mission − The overarching mission of the Institute is to improve the quality of the human condition and its environment • Five key areas of research − Genetics and Genomics, understanding how the genome regulates its function in health and disease − Structural Biology of Disease/Systems Approach − Developmental Biology − Computational Biology − Biomedically Directed-Engineering 7
Institute Design • Retained HDR, an internationally leading healthcare and research design and architecture firm • Examined other U.S. and international research institutes for design best practices • Developed core design principles: – Space flexibility – Space that facilities active collaboration – Space that includes key shared cores, including a biorepository 8
Governance • Established the GGBRI as a Virginia non-stock corporation; anticipate seeking tax exempt status • Named Dr. John Niederhuber as GGBRI CEO • Created an initial five person Scientific Advisory Committee (Dr. Margaret Shupnik, Dr. Steve Rich, Dr. John Niederhuber, Dr. John Deeken, Dr. Deborah Crawford) • Intend to establish an External Advisory Committee of nationally and internationally recognized scientific leaders 9
Update on Collaborative Partnerships • Inova-UVA signed MOU; held research retreat; established $500,000 joint seed fund for collaborative research – 27 proposals received, funded nine; GGBRI collaboration for Institute renovations and build out, Institute planning, and recruitment • Inova-GMU signed MOU; GGBRI collaboration for Institute renovations and build out and for development of proteomics core • Inova-VCU research retreat held; GGBRI collaboration for recruitments and programs and pharmacogenomics research collaboration based on UVA/VCU discussions • Inova, Virginia Tech, UVA analytics retreat held with interested commercial partners; working to establish predictive analytics partnership • Inova, UVA, and VCU co-hosted the V Foundation’s “Virginia Vine” cancer research event • UVA introduced the GGBRI partnership at the MedImmune BioHealth Capital Region Forum and the Cavendish Institute and the Cavendish Global Health Impact Forum • Met with VEDP to discuss commercial partnership recruitment opportunities 10
Capital Request for Lab Renovations and Enhancements (Budget Item 478.20 A.2.)
Statutory Requirements • Partnering Entities (Budget Item 478.20.B.1) : Inova Health System, University of Virginia and George Mason University. • Vetting Process (Budget Item 478.20.B.2) : The Institute’s Bylaws establish a Scientific Advisory Committee (SAC) with responsibility to review the initial plan for lab renovations and enhancements and/or research equipment to ensure that the renovated facilities and equipment will support state of the art research in the areas of genetics, functional genomics, functional biology, biology driven engineering, bioinformatics, personalized medicine and related translations research. Such vetting has taken place and the unanimous action of the SAC approving such plan is documented in our funding request. 12
Statutory Requirements • Matching Funds (Budget Item 478.20.B.3-4) – As reflected in Inova’s Letter of Commitment included with our funding request, Inova Health System has committed to contribute a minimum of Forty Million Dollars ($40,000,000) to be used for the Capital Project (renovations, enhancements, and build out) – As reflected in their respective Letters of Commitment included with our funding request, UVA and GMU have committed to collectively contribute a minimum of Twenty Million Dollars ($20,000,000) to be used for the Capital Project, at least half of which is from New Resources. • “New Resources” – None of these funds have been appropriated by the General Assembly for some other purpose, and none are being re-purposed for the Institute. 13
Design – Selection of HDR • HDR selected through a competitive qualification & interview process • HDR qualifications: – #1 Healthcare Design Firm • Modern Healthcare (for 13 consecutive years: 2003-2016) • World Architecture Survey and Building Design + Construction – #1 Science & Technology Design Firm • Building Design + Construction • +250M SF research space completed – 9 Lab of the Year Awards from R+D Magazine • 2016 Special Recognition for Design for University of Texas MD Anderson, Zayed Building for Personalized Cancer Care • National experts in translational health sciences lab facilities – UVA School Of Medicine MR #4 Building • Extensive experience in adaptive reuse and renovation projects 14
Design Concepts • Applied best practices from state of the art research labs: – MD Anderson BSRB – UCSF Diller Cancer Center – Moffitt Cancer Center – Johns Hopkins Kimmel Cancer Center – UT MD Anderson, Zayed Building for Personalized Cancer Care • Generation of ideas facilitated by: – Collaborative work environments that foster teaming and open communication – Ease of traveling between spaces (e.g., internal stairwells vs elevators) – Mix of spaces to work together or alone – Technical walls for image visualization and display – “Work cafés” as impromptu meeting spaces 15
Design Process 16
70% / 30% Target Ratio Wet Lab 70% Office / Dry Research 30% 17
Research Building – Stacking Diagram • xxx 18 18
Research Lab Floor – Concept Plan 19
Biorepository [In progress] 20
Timeline Pre-Development & Conceptual Development Construction Demolition • Base Building • Base Building Construction Permits: • Base Building Design Concept Design Complete: CD Preparation: 1/23/17 – 7/03/17 – 8/28/17 9/2/16 • Base Building Construction: 9/18/17 – 4/14/17 Schematic Design Complete: Demolition Bids: 5/22/17 – 6/12/18 11/11/16 • Tenant Improvement Permits: 1/3/18 – 6/02/17 Design Development Demolition Permitting: 2/27/18 • Tenant Improvement Construction: Complete: 12/13/16 6/05/17 – 6/23/17 Demolition: 6/26/17 – 2/28/18 – 12/31/18 • Tenant Occupancy: 12/31/2018 10/30/17 • Tenant Improvement Design Schematic Design: 2/6/17 – 6/16/17 Design Development: 6/5/17 – 9/8/17 Construction Documents: 9/18/17 – 1/23/18 21
Estimated Budget Architecture & Engineering $ 7,381,000 Construction $ 79,591,000 Fixtures, Furnishing & Equipment $ 3,500,000 Permits & Inspections $ 4,924,000 IT Infrastructure $ 7,060,760 Research Computing $ 2,500,000 Project Administration $ 4,121,000 General & Administrative $ 1,753,000 Total $ 110,830,760 Total rentable SF in the GGBRI is 201,736 SF 22
Request • Request: That VRIC approve the parties’ funding request in the amount of Twenty Million Dollars ($20,000,000) for lab renovations and enhancements and/or research equipment as provided in Budget Item 478.20.A.2. 23
Recruitment Request (Budget Item 478.20 A.1.)
Statutory Requirements • Partnering Entities (Budget Item 478.20.B.1) : Inova Health System, University of Virginia and George Mason University. • Vetting Process (Budget Item 478.20.B.2) : The Institute’s Bylaws establish a Scientific Advisory Committee (SAC) with responsibility to review the initial researcher recruitment to ensure that it is scientifically appropriate for the Institute. Such vetting has taken place and the unanimous action of the SAC approving such plan is documented in our funding request. 25
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