Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides - PowerPoint PPT Presentation

Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides Conference April 26, 2017, Ft. Collins, CO Kaken Pharmaceutical Co., Ltd. Agrochemicals & Animal Health Products Group Presented by Cynthia Smith, Conn & Smith, Inc. 1

Polyoxin D Zinc Salt Kaken Pharmaceutical Co., Ltd.  Exclusive world-wide:  TGAI producer  TGAI registrant  EP formulator  Japanese company  Fermentation technology expertise 2

Polyoxin D Zinc Salt Biochemical • Naturally occurring (Polyoxin D) • Nontoxic mode of action 3

Polyoxin D Zinc Salt US Formulations, Markets  Oso 5%SC (Certis; food use)  Organic use pending  PH-D WDG (Arysta; food use)  Conventional use only  Affirm WDG (Nufarm; T&O) 4

Polyoxin D Zinc Salt Targeted Crops  Grapes, berries  Cucurbits  Fruiting vegetables  Tree fruit  Tree nuts 5

Polyoxin D Zinc Salt Targeted Pests  Monilinia  Powdery mildew  Botrytis  Gummy stem blight  Southern blight  Apple summer diseases 6

Polyoxin D Zinc Salt Best Practices  Apply preventatively for best efficacy  Can be applied after pathogen is present  Typical 5%SC application rates  6.5 to 13 fl oz/A  0.36 to 0.72 oz ai/A  Resistance management tool  Risk reduction tool  IMP tool 7

Polyoxin D Zinc Salt Mammalian Toxicology  No endpoint for risk assessment  No acute to chronic effects  Not mutagenic, teratogenic  Not oncogenic, neurotoxic  No reproductive toxicity  No endocrine effects  Low absorption; high excretion 8

Polyoxin D Zinc Salt Environmental Toxicology  Practically nontoxic to:  Honeybee, ladybugs, and more  Birds, Algae  Earthworms, Beneficial soil fungi  Moderately toxic to:  Fish, Daphnia 9

Polyoxin D Zinc Salt Rapid Environmental Degradation DT 50 Degradation Route (Days) 0.4 Photolysis, natural water, sterile 2.3 Photolysis, pH 7 15.9 Aerobic soil 32.5 Hydrolysis, pH 7 10

Polyoxin D Zinc Salt Environmental Risk Risk = Exposure x Hazard  Low exposure  Low AI application rate  Rapid environmental degradation  Low risk  Including for fish and Daphnia 11

Polyoxin D Zinc Salt Non-Toxic Mode of Action  Does not kill the fungus  Competitive enzyme inhibitor  Interferes with fungal chitin synthesis  Sensitive fungus after treatment:  Changed morphology  Stop growing  Not pathogenic 12

Polyoxin D Zinc Salt Mode of Action Treated Untreated 13

Polyoxin D Zinc Salt Resistance Management Tool  Unique mode of action in N. America  FRAC 19  No resistance observed in over 40 years of commercial use in Asia 14

Polyoxin D Zinc Salt Crop Residue Risk Reduction Tool  0-day PHI (all crops)  US EPA tolerance exemption  All crops, pre- and post-harvest  40 CFR § 180.1285 15

Polyoxin D Zinc Salt International MRL “Exemptions”  Canada  Mexico  New Zealand  Taiwan  Korea (pending; summer 2017)  EU (pending) 16

Polyoxin D Zinc Salt MRL Trade Barrier: Japan  Toxicology data submitted  Not yet reviewed  MRL “exemption” harmonization recently requested  Under consideration 17

Polyoxin D Zinc Salt (5%SC) Blueberry / Mummyberry (KAK-2016-Blueberry-WA-Conv) Control Incidence Mummies Oso (6.5 fl oz/A) Incidence Flower, Oso (13 fl oz/A) Leaf Strikes 0 10 20 18

Polyoxin D Zinc Salt (5%SC) Sweet Cherry / Brown Rot (Oregon, 2015) (PDMR 10:STF009) Untreated Control Post-harvest Fruit Brown Rot (%) Oso (6.5 fl oz/A) + Induce Blossom Blight (%) Luna Sensation 0 5 10 15 20 19

Polyoxin D Zinc Salt (5%SC) Grapes / Powdery Mildew (California, 2012) (CER-2012-069) * Pristine, Rally, Quintec, Elite (FRAC 7+11, 3, 13, 3) 20

Polyoxin D Zinc Salt (5%SC) Tomatoes / Powdery Mildew (Greenhouse, Inoculated) (BCGGA-2015-03) 21

Polyoxin D Zinc Salt (5%SC) Strawberries / Botrytis Fruit Rot (KAK-2016-Sberry-MI) Fruit Rot Incidence (%) Untreated Control Oso (6.5 fl oz/A) Oso (13 fl oz/A) 0 5 10 15 20 25 30 35 40 22

Polyoxin D Zinc Salt (5%SC) Organic Strawberries / Botrytis (KAK-2016-Sberry-MD) (PDMR 11:SMF020) Infected Fruit Weight Water Control Organic Standard* Oso (6.5 fl oz/A) Oso (13.0 fl oz/A) 0 5 10 15 20 25 *[Regalia + Actinovate + Silwet] rotated with [Regalia + Serenade ASO + Silwet] 23

Polyoxin D Zinc Salt (5%SC) Cucumber / Gummy Stem Blight (BCGGA-2015-02) (Greenhouse, Inoculated) Untreated Control Severity (AUDPC) Oso (6.8 fl oz/A) Oso (13.7 fl oz/A) Incidence (AUDPC) Pristine, Nova 0 100 200 300 400 500 600 24

Polyoxin D Zinc Salt Organic Use Pending  National Organic Program petition  Oso 5%SC only  2019 to 2020 launch, if approved  Grower support is necessary 25

Questions? Contact: Cynthia Smith Regulatory Consultant for Kaken Conn & Smith, Inc. 703-339-1117 cindy@connsmith.com 26