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The Prescription Drug Overdose Epidemic: Epidemiology and Policy Len Paulozzi, MD, MPH March 27, 2014 National Center for Injury Prevention and Control Centers for Disease Control and Prevention National Center for Injury Prevention and


  1. The Prescription Drug Overdose Epidemic: Epidemiology and Policy Len Paulozzi, MD, MPH March 27, 2014 National Center for Injury Prevention and Control Centers for Disease Control and Prevention National Center for Injury Prevention and Control Division of Unintentional Injury Prevention

  2. Drug overdoses have surpassed motor vehicle crashes as the leading cause of injury death Motor Vehicle Traffic Poisoning Drug Poisoning (Overdose) 25 Deaths per 100,000 population 20 15 10 5 0 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 Year

  3. Predicted Age-Adjusted Death Rates due to Drug Poisoning: 1999-2000 2004-2005 2008-2009 Source: Rossen et al, 2013 , AJPM 3 3

  4. Opioid overdoses have driven the surge in overdose deaths 35,000 16,651 opioid deaths in 2010 30,000 25,000 4,030 opioid deaths in 1999 20,000 15,000 10,000 5,000 0 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 National Vital Statistics System, 1999-2010

  5. National Vital Statistics System, 2010

  6. Risk Factors  Demographics Socioeconomics and Geography • Men • Medicaid • 35-54 year olds • Rural • Whites Clinical Characteristics • American Indians/Alaska • Chronic pain Natives • Substance abuse • Mental health • Nonmedical use • Multiple prescriptions • Multiple prescribers • High daily dosage

  7. Middle-aged adults are at greatest risk for drug overdose in the US 30 Death rates by age 45-54 25 Deaths per 100,000 population 35-44 20 25-34 55-64 15 10 15-24 5 65 & over 0 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 CDC/NCHS, National Vital Statistics System

  8. Opioid analgesics users in the past month Medical Nonmedical users users 4.9 million 9.0 million National Survey on Drug Use and Health, 2012. http://www.oas.samhsa.gov

  9. Chronic nonmedical use of opioid analgesics has increased more than less frequent use 35 Rate per 1,000 population ≥ 12 years old 30 25 20 15 2002-2003 75% Increase 2009-2010 10 5 0 1-29 Days Past Year 30-99 Days Past Year 100-199 Days Past 200-365 Days Past Nonmedical Use Nonmedical Use Year Nonmedical Use Year Nonmedical Use Frequency of Past Year Nonmedical Use • Jones CM. Frequency of prescription pain releiver nonmedical use, 2002-2003 and 2009-2010. Arch Intern Med. 2012 Sep 10;172(16):1265-7;

  10. Emerging Issue: Increased heroin abuse or dependence Number of persons in the US 12+ years 2,500 2,056 2,000 (in thousands) 1,509 1,500 2002 2012 1,000 467 500 214 0 Abuse or dependence - opioid analgesics Abuse or dependence - heroin • SAMHSA NSDUH 2012

  11. Overdose deaths are the tip of the iceberg emergency department visits SAMHSA NSDUH, DAWN, TEDS data sets Coalition Against Insurance Fraud. Prescription for Peril. http://www.insurancefraud.org/downloads/drugDiversion.pdf 2007.

  12. Economic costs are high  $72.5 billion in healthcare costs 1  Opioid abusers generate, on average, annual direct health care costs 8.7 times higher than nonabusers 2 1. Coalition Against Insurance Fraud. Prescription for peril: how insurance fraud finances theft and abuse of addictive prescription drugs. Washington, DC: Coalition Against Insurance Fraud; 2007 2. White AG, Birnbaum, HG, Mareva MN, et al. Direct Costs of Opioid Abuse in an Insured Population in the United States. J Manag Care Pharm . 11(6):469-479. 2005

  13. Opioid deaths, sales, and treatment admissions have increased in lockstep 8 Opioid Sales (kg per 10k) 7 6 Opioid Deaths (per 100k) 5 4 3 2 Opioid Treatment Admissions (per 10k) 1 0 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 National Vital Statistics System, DEA’s Automation of Reports and Consolidated Orders System, SAMHSA’s TEDS National Vital Statistics System, DEA’s Automation of Reports and Consolidated Orders System, SAMHSA’s TEDS

  14. Drug overdose death rate 2008 and opioid pain reliever sales rate 2010 Kg of opioid pain relievers used per 10,000 Age-adjusted rate per 100,000 • National Vital Statistics System, 2008; Automated Reports Consolidated Orders System (2010)

  15. Just 3% of California workers compensation opioid p rescribers… Swedlow et al. Prescribing patterns of schedule II opioids in California Workers’ Compensation, CWCI Institute, 2011

  16. 3% of prescribers 62% of all morphine 65% of all equivalents 55% of all CSII associated opioid Rx payments Swedlow et al. Prescribing patterns of schedule II opioids in California Workers’ Compensation, CWCI Institute, 2011

  17. Pivot to Prevention  Prescription Drug Monitoring Programs (PDMPs)  Patient Review & Restriction Programs  Laws/Regulations/Policies  Insurers & Pharmacy Benefit Managers (PBM)  Clinical Guidelines

  18. Prescription Drug Monitoring Programs (PDMPs) Status of PDMPS – September 2013 Source: Alliance of States with Prescription Monitoring Programs

  19. Multiple-provider episode rates* for CS II drugs, Quarter 4 of 2011 vs. Quarter 4 of 2012, Florida 8 Rate per 100,000 residents 6.9 7 6 4.7 5 4 Q4 2011 3 2.6 Q4 2012 1.9 1.8 2 0.8 1 0.0 0.0 0 <18 18-34 35-54 55+ Age Group *Having CSII rx from 5+ prescribers dispensed at 5+ pharmacies during one quarter. Limited to state residents. Source: Prescription Behavior Surveillance System 19

  20. Patient Review and Restriction Programs (aka “Lock - In” Programs)  APPLICATION: Patients with inappropriate use of controlled substances  STRATEGY: 1 prescriber and 1 pharmacy for controlled substances  OUTCOME: Improve coordination of care and ensure appropriate access for patients at high risk for overdose  IMPACT: Cost savings as well as reductions in ED visits and numbers of providers and pharmacies

  21. Laws/Regulation/Policies  STATE RESPONSE: Some states have enacted laws & policies aimed at reducing diversion, abuse & overdose  KEY AIM: Strengthen health care provider accountability  PATIENT PROTECTION: Safeguard access to treatment when implementing policies  GAP: Rigorous evaluations to determine effectiveness and identify model components

  22. Insurer/Pharmacy Benefit Manager (PBM) Mechanisms  Reimbursement incentives/disincentives  Formulary development  Quantity limits  Step therapies/Prior Authorization  Real-time claims analysis  Retrospective claims review programs

  23. Clinical Guidelines  Improve prescribing and treatment  Basis for standard of accepted medical practice for purposes of licensure board actions  Several consensus guidelines available  Common themes among guidelines

  24. Conclusions  BURDEN: Overdose deaths from prescription drugs have reached epidemic levels in the United States  KEY DRIVERS: Defining the drivers of the epidemic are critical to effective solutions  SCOPE OF SOLUTION: Multifaceted approach is needed. Recent successes promising  KNOWN EFFECTIVENESS: Interventions must be evaluated to determine effectiveness and need for state-specific adaptation

  25. Thank You Len Paulozzi lbp4@cdc.gov The findings and conclusions in this report are those of the author and do not necessarily represent the views of the Centers for Disease Control and Prevention. National Center for Injury Prevention and Control Division of Unintentional Injury Prevention

  26. The Prescription Drug Action Committee (PDAC) Injury Prevention Prescription Drug Webinar State of Delaware Update March 27, 2014 Co-Chairs Karyl Rattay, MD, MS, Director, Delaware Division of Public Health Randeep Kahlon, MD, Past President of the Medical Society of Delaware Presentation By: J. Kevin Massey

  27. Prescription Drug Abuse and Misuse in Delaware • Delaware: 9 th highest drug overdose death rate (2009) – DE average deaths per 100,000 population: 12.6 – National average deaths per 100,000: 12.0 – Drug overdose death rate increased 142% (1999-2009) • More Delaware residents 12 and older report using non-medical use of opioid pain relievers – DE average: 5.6% – National average: 4.8% • Substance abuse treatment admission rates for opioids increased over 2,750% (1999-2010) • Delaware 5 th highest for opioid sales (2010) – DE average: 10.2 KG per 100,000 population – National average: 7.1 KG per 100,000 population

  28. Drug Overdose Death Rate, 2008, and Opioid Pain Reliever Sales Rate, 2010 Kg of opioid pain relievers used per 10,000 Age-adjusted rate per 100,000 National Vital Statistics System, 2008; Automated Reports Consolidated Orders System, 2010.

  29. A Coordinated Approach to Action – The Prescription Drug Action Committee, PDAC  History  Established in February 2012.  Focused on coordinating public, private and community efforts under the leadership of the Division of Public Health and the Medical Society of Delaware.  The PDAC has a broad and diverse membership.  To date, has conducted 18 full committee public meetings and over 50 sub committee meetings.  The PDAC has developed a comprehensive set of recommendations to combat drug abuse, misuse and diversion statewide. Implementation of these recommendations is ongoing.  You can access our PDAC report on our website address: http://dhss.delaware.gov/dhss/dph/pdachome.html

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