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Orophary ryngeal Dysphaga And Frail ility: Can It It Be Rela lated? Glistan BAHAT, zlem YILMAZ , kran DURMAZOLU, Cihan KILI, Baar AYKENT, Mehmet Akif KARAN CONFLICT OF INTEREST DISCLOSURE I have no potential conflict of

  1. Orophary ryngeal Dysphagıa And Frail ility: Can It It Be Rela lated? Gülistan BAHAT, Özlem YILMAZ , Şükran DURMAZOĞLU, Cihan KILIÇ, Başar AYKENT, Mehmet Akif KARAN

  2. CONFLICT OF INTEREST DISCLOSURE I have no potential conflict of interest to report

  3. Infections Objective Malnutrition (Related aspiration) Functionality • Community dwelling elderly people → Oropharyngeal dysphagia (OD) ↓ frequency ↑ • Etiology  Multiple factors • Usually an ignored clinical problem • OD  A geriatric syndrome ↑ Mortality • OD  Associated with adverse outcomes 1.Wirth, Rainer, et al. Clin Interv Aging 2016, 11: 189. 2.Sura L, et al. Clin Interv Aging. 2012;7:287-98.

  4. Objective Treatment • Fraility  Major interest in geriatrics strategies • Frail older adult  Major issue of geriatrics Survivor expectation

  5. Objective • Fraility ↑↑  In elderly • OD ↑↑  In elderly - ↑ more in nursing homes - ↑ in the presence of neurodegenerative disease Is there a relationship between them ??

  6. Objective • Fragility-OD relationship in literature 1,2,3 -A few Studies -Limited number of cases available -Indirectly link available • Independent relationship? 1. Rofes L, et al. Neurogastroenterol Motil 2010; 22: 851-8.e230 2. Wakabayashi, H. Clinical calcium , 2014, 24.10: 1509-1517 3. Hathaway, B, et al. Annals of Otology, Rhin & Laryn. , 2014, 123.9: 629-635.

  7. Material and and method: • Prospective, Cross-sectional and Consecutively • Elderly patients evaluated from our outpatient clinic (≥60 y) BMI Measurement Malnutrition • July 2015-September 2016 (15 months) Hand grip • Age, sex, total illness and total number of medicines, presence of Frailty strenght FRAIL scale MNA-SF neurodegenerative disease, Katz GYA Calf • Dysphagia scanning  with EAT-10 questionnaire (2 thresholds for circumference EAT-10  3 and ≥ 15) * Usual walking speed(UWS) *Cheney, et al. Annals of Otology, Rhin. & Laryn. , 2015, 124.5: 351-354.

  8. Material and and method: : Statistics • Parameters with OD: univariat analysis (chi-square, ...) • OD independent factors: Regression (Linear and Logistic regression analysis)

  9. Results 1138 elderly people EAT-10 questionnaire was applied • Average age  74.1± 7.3 (60-98) • 348 (30.6 %) male and 790 (69.4%) female

  10. Results • EAT -10 questionnaire  1138 • ≥ 3 threshold  dysphagia -63.7 %, (n=413) • ≥ 15 threshold  dysphagia - 6.7 %, (n=76)

  11. Results • FRAIL scale was applied to 851 patients. Fraility is around 28% in total Fraility Female Male Total (n=851) Normal 122 ( 21.1 %) 103 (37.9%) 225 (28.4 %)  Female 32 %(n=579) Prefrail 269 ( 46.5 %) 116 (42.6%) 385 (45.2 %)  Male 19 % (n=272) Frail 188 (32.5%) 53 (19.5%) 241 (28.2%) Total 579 272 851

  12. Results • FRAIL data are available in 851 patients  EAT-10 ≥ 3 : 62.0 % (n=527) EAT-10 ≥15 : 4.9 % (n=42) Frail+ EAT-10 ≥ 3  73.1 % (n=176) Frail + EAT-10 ≥ 15  13.6 % (n=33)

  13. Significant findings in univariate analyzes Variables EAT ≥ 3 EAT ≥ 15 n p n p Age 1138 0,05 1138 0,02 Total illness number 1130 0,003 1130 0,001 Total drug number 1125 <0,001 1125 < 0,001 Hand grip strength 561 <0,001 561 0,002 UWS 469 0,03 469 0,01 Fraility 851 <0,001 851 <0,001 MNA SF 563 <0,001 563 0,001 Female 790 <0,001 790 0,001 Neurodegenerative disease 184 0,002 184 0,003 BMI 563 0,009 563 0,7 Katz ADL 565 <0,001 565 0,001

  14. Significant findings in univariate analyzes Variables EAT ≥ 3 EAT ≥ 15 n p n p Age 1138 0,05 1138 0,02 Total illness number 1130 0,003 1130 0,001 Total drug number 1125 <0,001 1125 < 0,001 Hand grip strength 561 <0,001 561 0,002 UWS 469 0,03 469 0,01 Fraility 851 <0,001 851 <0,001 MNA SF 563 <0,001 563 0,001 Female 790 <0,001 790 0,001 Neurodegenerative disease 184 0,002 184 0,003 BMI 563 0,009 563 0,7 Katz ADL 565 <0,001 565 0,001

  15. In In regression analysis EAT-10 ≥ 3 Variables Sig. Exp(B) Age 0,649 0,992 Total illness number 0,135 0,883 Total drug number 0,016 1,142 Hand grip strength 0,219 0,977 UWS 0,818 0,884 Fraility 0,012 1,282 MNA SF 0,796 0,984 Female 0,897 0,961 Neurodegenerative disease 0,627 1,174

  16. In In regression analysis EAT-10 ≥ 15 15 Variables Sig. Exp(B) Age 0,449 0,967 Total illness number 0,717 0,935 Total drug number 0,081 1,220 Hand grip strength 0,336 0,941 UWS 0,769 0,658 Fraility 0,042 1,673 MNA SF 0,987 1,002 Female 0,699 1,456 Neurodegenerative disease 0,276 0,438

  17. In In regression analy lysis According to EAT-10 total score Unstandardized Coefficients Standardized Coefficients Model B Beta Sig . Age -0,054 -0,086 0,124 Total illness number -0,184 -0,085 0,252 Total drug number 0,268 0,195 0,010 Hand grip strength -0,024 -0,046 0,519 UWS -0,194 -0,012 0,856 Fraility 0,738 0,203 <0,001 MNA SF -0,187 -0,078 0,113 Female -0,351 -0,036 0,574 Neurodegenerative disease 0,036 0,003 0,957

  18. Discussion

  19. We have found 16 results '' fraility oropharyngeal dysphagia '' in Pubmed

  20. 6 study were unconcerned Only 6 original 4 review paper

  21. 2015 15 studies were reviewed 9947 elderly people High quality 6 studies  fraility(r = 0.34) However, there is insufficient evidence to describe independent risk factors at this time

  22. Are the results sim imil ilar to our r study? : : Why hy? • Studies on the components of the fraility • Similar to our study because it reflects indirectly fraility but • Independent fraility relationship could not be shown in the studies.

  23. Our study is strong because .. ... • We have too much patients • We included all the cases (no bias) • We examined a large number of factors (including neurodegenerative diseases) • We examined the patients we met each day (important for our practice) Missing aspects • It is not cross-sectional • Cause-effect relationship can not be established.

  24. Why/how OD OD-Fraility are rela lated? Fraility Oropharyngeal Dysphagıa

  25. Conclusions Hand grip strength Hand grip strength +FRAIL are evaluated together Usual  Hand grip strength losed its significance Fraility walk Functionality UWS+MNA+FRAIL are evaluated together speed  UWS+MNA losed their significance Malnutrition

  26. Conclusions Hand grip strength, UWS, MNA,EGYA +FRAIL are evaluated together Only Fraility is significance • In the other studies this indirect relationship was shown (IADL and muscle strength are significant an indirect indicator of fraility)

  27. Thank you for your attention

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