CHEM 4710 2013 ‐ 2014 Honours Research Project in Chemistry or Biochemistry Oral Presentations Saturday, April 12 Buller 207 Program and Abstracts
Program 9:00 Reception, coffee Buller 207 Determination of the Compatibility of Current Forensic 9:20 Ashley Gordon Collections & Analysis with GC ‐ MS Techniques for Latent Dr. Gregg Tomy Fingerprints 9:40 David Smith New Catalyst Designs for the Electrochemical Reduction Dr. David Herbert of CO 2 Swai Mon Khaing Identification of proteins associated with Connexin36 10:00 Dr. James Nagy using mass spectrometry Dr. Hélène Perreault 10:20 James Lloyd Synthesis and Structural Characterization Dr. Mario Bieringer of Ca (1 ‐ x) Sr x In 2 O 4 (0 ≤ x ≤ 1) 10:40 Break 11:00 Ewan McRae Recombinant Expression of the RHAU Helicase protein Dr. Sean McKenna in E. coli 11:20 Sterling Desmond Rotational Levels within the Vibrational Spectra Dr. Jennifer van Wijngaarden of Thietane and Oxetane 11:40 Katherine Cordova Development of immunoglobulin G modified silica beads as Dr. Hélène Perreault a novel stationary phase for glycopeptide enrichment 12:00 Patrick Giesbrecht Formation of a Conducting Polymer ‐ WO 3 Bulk Dr. Michael Freund Heterojunction for Resistive Memory 12:20 Pizza Lunch Parker 256 1:20 Rebecca Sherbo Synthesis and Characterization of Rhodium β‐ diiminate Dr. Peter Budzelaar Complexes 1:40 Benchmen Choun Trieu Synthesis of Antimicrobial Peptides Containing Dr. Frank Schweizer Pro ‐ Arg ‐ Pro Repeating Motifs 2:00 Heather Cavers Functionalization and Characterization of Representative Dr. Michael Freund Model Crystal Surfaces on Silicon Microwires 2:20 Roy Hutchings Purification and crystal screening of the cytoplasmic tail segment of a K + /H + antiporter from Vibrio cholerae Dr. Jörg Stetefeld 2:40 Break 3:00 Shaun MacLean Computational Study of a Binuclear Pentavalent Uranyl Dr. H. Georg Schreckenbach Complex in a Schiff ‐ Base Polypyrrolic Macrocycle FTIR spectrochemical analysis of nutritional composition of 3:20 Alexandra C. Ciapala the diatom Fragilaria cylindrus after exposure to varying Dr. Kathleen M. Gough light levels 3:40 Hayden Glor Specific Ion Effects on Micellization Dr. Mazdak Khajehpour of a Non ‐ Ionic Surfactant 4:00 Close Refreshments Parker 256
CHEM 4710 2013 ‐ 2014 Honours Research Project in Chemistry or Biochemistry Determination of the Compatibility of Current Forensic Collections & Analysis with GC ‐ MS Techniques for Latent Fingerprints Ashley Gordon Supervisor: Dr. Gregg Tomy Abstract: Since the 20 th century, police have collected fingerprints in an attempt to solve crimes. During this time, physical and chemical techniques have been utilized to visualize latent fingerprints (LFP) to the naked eye. Within the last decade, technology has developed to the point where the chemical components that compromise LFP can be analyzed and quantified. LFP is a combination of eccrine and sebaceous gland secretions containing water, amino acids, lipids, urea, salts, etc. The purpose of this study was to determine if current forensic techniques to visual LFP is compatible with residue analysis by gas chromatography mass spectrometry (GC ‐ MS). This was achieved by first generating electron ionization (EI) full ‐ scan mass spectra of all the analytes under investigation including a suite of amino acids, fatty acids, urea, cholesterol, squalene and lactic acid. The two most unique and abundant ions from the EI full scan mass spectrum of each analyte were selected and used in the final selected ion monitoring (SIM) method. Finally, authentic fingerprints samples were obtained from donors by pressing their dominate thumb onto a glass slide. Fingerprint powder, cyanoacrylate superglue and a ninhydrin analog were each applied to the LFP and tested using the developed extraction and GC ‐ EI ‐ SIM ‐ MS method.
CHEM 4710 2013 ‐ 2014 Honours Research Project in Chemistry or Biochemistry New Catalyst Designs for the Electrochemical Reduction of CO 2 David Smith Supervisor: Dr. David Herbert Abstract: Carbon dioxide, believed to be a major contributor to climate change, is constantly being emitted into the atmosphere due to a heavy reliance on fossil fuels for energy production. Being able to convert CO 2 back into usable fuels would decrease net emissions and allow for a carbon ‐ neutral source of energy. Being a stable linear molecule with strong double bonds, it is difficult to accomplish this. An effective electrocatalyst could allow one to reduce CO 2 and transfer energy from renewable electric sources into fuels that can be burned as traditional fossil fuels. An effective catalyst would require that the CO 2 be bound so that an efficient electron transfer could occur. Some potential catalysts use late transition metals to bind the CO 2 molecule, with hydrogen bonds helping to stabilize the bound CO 2 . Synthesizing a catalyst containing a late transition metal, along with a redox inactive Lewis acid could allow for stronger binding and more efficient electron transfer to reduce the required energy for CO 2 reduction. Efforts towards including pnictogen elements as Lewis acidic additions to a ligand set for a Nickel based electrocatalyst will be discussed.
CHEM 4710 2013 ‐ 2014 Honours Research Project in Chemistry or Biochemistry Identification of proteins associated with Connexin36 using mass spectrometry Swai Mon Khaing Supervisors: Dr. James Nagy, Dr. Hélène Perreault Abstract: Identification of protein interaction networks using mass spectrometry is a powerful approach to gain understanding of complex protein systems in mammalian central nervous system (CNS). Electrical synapses between neurons in the mammalian CNS are formed by gap junctions composed mainly of the gap junction ‐ forming protein connexin36 (Cx36). In this study, lysates of HeLa cells stably transfected with Cx36 (HeLa ‐ Cx36) were immunoprecipitated (IPed) with anti ‐ Cx36 antibodies. The presence of Cx36 in the IP samples was confirmed by immunoblotting. Identification of proteins that co ‐ IPed with Cx36 was achieved by subjecting samples to in ‐ gel or on ‐ bead tryptic digestion followed by matrix ‐ assisted laser desorption/ionization mass spectroscopy (MALDI ‐ MS). Although database analysis of MALDI ‐ MS data did not indicate peptides for Cx36 in any of the samples, it did however reveal the presence of peptides from several other proteins, including those that matched the E3 ubiquitin ligase smad regulatory factor ‐ 2 (SMURF2). SMURF ‐ 2 was recently shown to be recruited to gap junctions composed of another member of the connexin family of proteins, namely connexin43 (Fykerud et al, 2012). Subsequent immunofluorescence showed co ‐ localization of Cx36 with SMURF ‐ 2 in HeLa ‐ Cx36 cells. This finding calls for further research to understand SMURF ‐ 2 interactions with Cx36 in HeLa ‐ Cx36 cells.
CHEM 4710 2013 ‐ 2014 Honours Research Project in Chemistry or Biochemistry Synthesis and Structural Characterization of Ca (1 ‐ x) Sr x In 2 O 4 (0 ≤ x ≤ 1) James Lloyd Supervisor: Dr. Mario Bieringer Abstract: Photoluminescent materials are used in LED displays and are often rare earth cation doped metal oxide host structures. One such example is the rare earth doped CaIn 2 O 4 and SrIn 2 O 4 host structures 1 . Despite the large volume of research published regarding the photoluminescent properties of these rare earth doped phases, little work has been devoted to the parent oxides. The literature even contains conflicting 2,3 and even more surprisingly, the solid solution Ca (1 ‐ x) Sr x In 2 O 4 (0 ≤ x ≤ 1) has structural reports for CaIn 2 O 4 never been reported. The expected solid solution will provide an opportunity to tune the photoluminescent properties by means of controlling the host lattice. Here the synthesis and structural characterization of the solid solution of Ca (1 ‐ x) Sr x In 2 O 4 (0 ≤ x ≤ 1) is reported for the first time. Powder X ‐ ray diffraction techniques were used to follow the synthesis, identify products and clarify structural details of these phases. The research addresses the synthesis conditions and the structural evolution of the solid solution, details regarding Ca 2+ /Sr 2+ cation ordering and the potential presence of competing phases will be presented as well. 1) Li T., Guo C., Yang Y., Li L., Zhang N., Acta Materialia 2013, 61, 7481 ‐ 7487 2) Cruickshank F., Taylor D., Glasser F., J. Inorg. Nucl. Chem. 1964 , 26 , 937 ‐ 941 3) Reid A., Inorg. Chem. 1967 , 6 , 631 ‐ 633
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