Έρευνα και ανάπτυξη προϊόντων Κωνσταντίνος Γαρδίκης , MSc, PhD, Scientific Affairs Director
APIVITA BRAND APIVITA is a highly sophisticated natural cosmetics brand, developing and producing natural, effective and holistic cosmetics and well being products and services
GREEK FLORA INSPIRATIONS BEE SOCIETY HIPPOCRATES
OUR DRIVING AXIS 1. Our Brand Identity 2. APIVITA strategic goals on Raw Materials Development 3. Market research defining Cosmetics and Health market status 4. Scientific Collaborations & Research Programs 5. Cosmetics Legislation Evolution . Product Development Platform … driven by Value 6. Innovation Innovation
WHAT MAKES OUR PRODUCTS UNIQUE
36 YEAR RESEARCH & Scientific collaboration with universities and research institutes for extensive research on Greek plant actives and applications DEVELOPMENT 7 research programs in collaboration with the University of Athens accomplished and 10 in progress EVOLUTION In house plant extracts and oils development and production 60 plants studied / 200 extracts developed since 1979 37 years proven experience in natural products development Experience and flexibility leads to more than 100 new product developments every year Extensive knowledge of natural and organic cosmetics (the first in the Greek market to produce natural cosmetics, the first in the Greek pharmacies to produce organic sunscreens). Extensive ingredients testing and deep under- standing 5000 ingredients tested / 1500 ingredients used. New developments in increasing products natural ingredients level such as innovative preservation Certifications systems, emulsifying systems, active ingredients.
A success story of innovation The department consists of 14 scientists, chemists, pharmacists, chemical engineers and cosmetologists who are in charge of the development of natural raw materials, cosmetic products’ formula and notification & legalization of the products to the countries of company’s operation
PRODUCT NATURAL – EFFECTIVE - HOLISTIC
APIVITA products have formulas with high percentage of natural ingredients 85%-100% , environmentally friendly packaging and they are produced with respect to nature. NATURAL
WITH Plant extracts Plant oils Plant Infusions NATURAL Bee Products Essential oils *Greek plant, organically cultivated, Hippocrates plants WITHOUT Parabens Silicones Propylene Glycol Mineral Oil Ethanolamines Phthalates, Nitromusks, Polycyclic Musks
PLANT EXTRACTS H ippocrates Organic Plants : 99% of the plants we B otanical use for the in house production of G arden on extracts are from organically certified K os island cultivations Greek Plants : Combining the knowledge of the traditional use and modern scientific research on the Greek biodiversity Hippocrates Plants : Thorough study of his literature brought to light the exact plant species which he used for his therapeutic methods.
APIVITA’s R&D department has a proven track record of experience in developing effective cosmetics. The ingredients used are on the cutting edge of green cosmetology and fulfills efficacy substantiation requirements EFFECTIVE Ingredients' activity and effectiveness is measured in house and in collaborations In vivo clinical studies are conducted on the final products in close partnership with research institutes and universities.
PROOF OF EFFICACY Phytochemistry Lab Qualitative Chromatographic analysis analysis (HPTLC, HPLC) Quantitative analysis Microbiological tests Total phenolics (Folin- Ciocalteau method) Analytical tests Total Flavonoids UV-Vis spectrophotometry Total Phenolics Physicochemical tests Radical Scavenging (DPPH) (pH, Specific gravity etc)
PROOF OF EFFICACY Biochemistry Lab Allergen identification Elisa Immunosorbent Assay Protein detection Gene expression Real Time Polymerase Chain Biochemistry Microbiological testing Reaction (qPCR) assays DNA barcoding Gel Electrophoresis Genetic fingerprinting
PROOF OF EFFICACY Gene Database 200 API - Genes Extracellular Molecules Ageing Apoptosis Oxidative Stress Hydration Response Transcription to Stress Regulators Inflammation Cell growth and Proliferation
PROOF OF EFFICACY In-vivo tests Results Skin moisturization is improved by 18% after the • first application and by 21%, after 28 days 24 h , Skin moisturization • TEWL is decreased by 18% after 28 days • Skin elasticity is improved by 16% after 28 days • Results Skin’s density was improved at 87% of the • volunteers after 46 days Skin’s tone was improved at 97% of the volunteers • after 46 days Skin’s texture was improved at 90% of the • volunteers after 46 days
HOLISTIC INSPIRED BY HIPPOCRATES Holistic approach on health and beauty based on Hippocrates Philosophy The teaching of Hippocrates on Experience, HOLISTIC Methodology,Discipline and Evidence is a key inspiration on new product development Multifunctional products which offer more than one action & cover all skin's needs. Maintain skin’s health and beauty. Formulas enriched with 100% pure organic essential oils in order to enhance a feeling of well being
INGREDIENTS NATURAL – EFFECTIVE - HOLISTIC
PLANT INFUSIONS Replacing water with herbs infusions to INNOVATION enhance effectiveness Calendula Mountain Rosemary water Greek Wild rose Chamomile water (marigold) water Tea infusion Infusion Anti-irritant Calming Antioxidant Toning and and anti-aging action soothing soothing action action action action
EFFECTIVE PLANT INFUSIONS Effectiveness of herb infusions is measured by scientific methods • Total phenolic content is assessed by Folin-Ciocalteau assay • The ability of the infusion to scavenge free radicals is measured by DPPH method Antioxidant activity 0,2 Trolox equivalent 0,15 0,1 0,05 0 Sideritis Sideritis scardica Sideritis raeseri Sideritis perfoliata Green tea blend
SIDERITIS INFUSION PATENT Sideritis scardica/raeseri/perfoliata (PATENT USE)
EFFECTIVE BEE PRODUCTS SOPHISTICATED Propolis SKIN DELIVERY SYSTEMS : (PATENT METHOD) Propolis Encapsulation In Cyclodextrins
EFFECTIVE BEE PRODUCTS A patent of innovative extraction method and simultaneous SOPHISTICATED encapsulation in cyclodextrins SKIN DELIVERY SYSTEMS : Propolis Encapsulation In Cyclodextrins 8 In Vitro Studies 1. Cell Viability Protection- UV treatment 2. Cell Viability Protection – Heavy metal treatment 3. Cell Metabolism Protection – UV Treatment 4. Cell Metabolism Protection – Heavy metal treatment 5. Cell antioxidant capability- UV treatment 6. Cell antioxidant capability – Heavy metal treatment 7. Collagen synthesis 8. Elastin Synthesis
EFFECTIVE BEE PRODUCTS SOPHISTICATED ‘ SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in Liposomes Benefits of a liposomal formulation Royal Jelly forms in presence of soy lecithin (phospholipids) vesicles, the liposomes The active ingredients of Royal Jelly are incorporated either in the core of the vesicle or integrated in the phospholipid bilayer
EFFECTIVE BEE PRODUCTS SOPHISTICATED SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in Liposomes in-vivo Clinical studies Increase of skin firmness skin in 90% of volunteers Increase of skin elasticity in 90% of volunteers Reducing the depth of wrinkles in 85% of volunteers Growth stimulation of fibroblasts
RESEARCH PROGRAMS NATURAL – EFFECTIVE - HOLISTIC
HORIZON 2020 PROGRAMS
1 st round: 16.000 proposals 1 st stage success: 11% 2 nd stage success: 16% 28
HORIZON 2020: MARISURF Title: Novel, sustainable marine bio-surfactant / bio-emulsifiers for commercial exploitation • Call: H2020- Blue Growth-- ‐3 -- ‐2014 • Topic: : Novel marine derived biomolecules and industrial biomaterials • Type of action: Research and Innovation actions • Target : Isolation and production of new bio-surfactants and bio- emulsifiers by environmental pollution degrading bacteria (green biotechnology and sustainability) • APIVITA interest : Cosmeceutical formulation / green marketing • Total Budget : 4750000 euro • APIVITA budget : 198000 euro • Reimbursement rate : 100% • Duration : 60 months • Start date : 9/2015 29
PARTICIPANTS PARTICIPANT NO PARTICIPANT ORGANIZATION NAME COUNTRY 1 (Coordinator) HERIOT WATT UNIVERSITY UK 2 ULSTER UNIVERSITY UK 3 UNIVERSITY OF PATRAS GREECE 4 DEMOCRITUS UNIVERSITY OF THRACE GREECE 5 APIVITA, S.A. GREECE 6 BIO BASE EUROPE PILOT PLANT BELGIUM 7 ECOVER BELGIUM 8 ACONDICIONAMIENTO TARRASSENSE SPAIN 9 NOVA INSTITU Gmbh GERMANY 10 NANOIMMUNOTECH, S.L. SPAIN 11 ETS ITALY 12 MARLOW FOODS UK 13 MACHPIE UK 30
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