Monitoring of Sales of Veterinary Antim icrobial Agents in the UK Dr Nick Renn Dr Kay Goodyear Veterinary Medicines Directorate
BACKGROUND o 1999 – Advisory Committee on the Microbiological Safety of Food (ACMSF) recommended that VMD should publish data on volume of veterinary antimicrobials used in the UK. o In the UK there is no system which collects veterinary prescription data. o Used manufacturers’ sales data.
BACKGROUND ( ii) o 1998 - 2004 data provided on voluntary basis. o 2005 - implemented Art 27a of Directive 2001/ 82/ EC as amended to make the provision of data a statutory requirement: in the Veterinary Medicines Regulations 2005 et seq . o Annually publish the previous year’s data on sales of veterinary antimicrobials.
DATA COLLECTI ON o In April: write to every manufacturer with a Marketing Authorisation for any antimicrobial for the collection year. o Asked to provide sales for each product in a specific format: Product Active Concentration Unit Size Quantity Sold Volume of Quantity of Ingredient Product Active (Name) Ingredient A Neomycin 100mg/kg 1 x 10Kg 40,000 40,000 40,000 B Sulphadiazine 50mg/ml 20 x 100ml 100,000 2,000,000 100 C Trimethoprim 10mg/ml 20 x 100ml 100,000 2,000,000 20
DATA COLLECTI ON ( ii) o All Company data are collated into a spreadsheet o Additional data are added to the spreadsheet for each product, including: o Administration Method o Chemical Class o Species on the Marketing Authorisation o The data are QA checked before any calculations are performed
For each product � Calculate the quantity of antimicrobial � Apply a correction factor to account for the antimicrobial activity of the antimicrobial molecule � Report tonnes of active ingredient
Results 2008 report covered: o 370 products. o Approx 490 data entries/ calculations. o 5 food-producing species. o 3 key pet animals o plus other minor species.
DATA REPORTI NG Data are broken down by eg: o POM/ SFA (distribution category) o Numbers of Products Sold o Chemical Class o Individual Animal Species o Route of Administration o Food and Non-Food Producing Animals o Relations to Meat and Milk Production
Antim icrobial Class 250 Tonnes Active Ingredient Sold 200 150 100 50 0 2003 2004 2005 2006 2007 2008 Year Tetracyclines Trim/Sulph B-Lactams Aminoglycosides Macrolides Fluoroquinolones Others
Food and other anim als 400 Tonnes Active Ingredient Sold 350 300 250 200 150 100 50 0 2003 2004 2005 2006 2007 2008 Year Food Animals Only Non Food Animals Only Food and Non Food Animals
Route of adm inistration 350 Tonnes Active Ingredient Sold 300 250 200 150 100 50 0 2003 2004 2005 2006 2007 2008 Year Medicated Feedingstuffs Oral / Water Injectables Intramammaries Others *
Am ounts by sector 300 Tonnes Active Ingredient Sold 250 200 150 100 50 0 2003 2004 2005 2006 2007 2008 Year Cattle Only Pig Only Poultry Only Sheep Only Fish Only Pig and Poultry Only Multiple Food-Producing Species
Anim al Production 2,500 Tonnes (Thousand) Animal Production 2,000 1,500 for Food 1,000 500 0 2003 2004 2005 2006 2007 2008 Year Cattle Pigs Sheep Poultry Fish
Conclusion o The approach provides for most policy issues o 11 reports published to date and available on web site (www.vmd.gov.uk) o Enhancing the report year on year to make it more meaningful to stakeholders o 2009 data collection will start in April 2010 and will be published in 2010
DATA CALCULATI ONS Product Product X Active Ingredient Chlortetracycline hydrochloride � . Concentration 73.2g/ 1Kg Sales 5,000 Pack Size 22.5 Kg Proportion A.I. 73.2/ 1000 i.e. 0.0732 Factor 0.93 Calculation of Kg A.I. sold therefore is: 5 ,0 0 0 x 2 2 .5 x 0 .0 7 3 2 x 0 .9 3 = 7 6 5 8 .5 Kg
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