miR-24 and YKL-40 in Abdominal Aortic Aneurysm Lars Maegdefessel, MD - PowerPoint PPT Presentation

Oct 21, 2023 •103 likes •251 views

miR-24 and YKL-40 in Abdominal Aortic Aneurysm Lars Maegdefessel, MD PhD, Uwe Raaz, MD PhD, Joshua M. Spin, MD PhD, Per Eriksson, PhD, Anders Hamsten, MD PhD, Philip S. Tsao, PhD Abdominal Aortic Aneurysm (AAA) Dilation of the infrarenal

miR-24 and YKL-40 in Abdominal Aortic Aneurysm Lars Maegdefessel, MD PhD, Uwe Raaz, MD PhD, Joshua M. Spin, MD PhD, Per Eriksson, PhD, Anders Hamsten, MD PhD, Philip S. Tsao, PhD
Abdominal Aortic Aneurysm (AAA) • Dilation of the infrarenal aorta (> 3.0cm) • AAAs are common, lethal • 5-16% men; 1-2% women > 65y/o • Associated with atherosclerosis – Family History – Age – Male Sex – Hypertension – History of Smoking – Diabetes (-) • No effective therapy for early disease
Murine AAA Model: PPE Infusion AAA Diameters Measured by US 1.80 1.60 AGED NICOTINE Expansion in mm 1.40 1.20 MALE FEMALE 1.00 DIABETIC 0.80 SALINE 0.60 28 Pre 3 7 10 14 21 Post-Operative Days
microRNA Microarray - Mouse (Agilent™) Diabetes Nicotine 87 97 42 é é miR-21 65 72 ê ê miR-29b 93 97 Female Aged ê ê miR-23b-24-27b
Gene Expression Microarray – Mouse (Agilent™) éé éé 988 targets of the miR-23b-24-27b family Diabetes Female Nicotine Aged Male
miR-23b-24-27b and Targets in PPE-AAA
Regulation of AAA by miR-24/YKL-40 Cytokines miR-24 YKL-40 (phospho)-AKT Apoptotic Anti-apoptotic effects on macrophages, T-cells, eosinophils
Modulation of miR-24 in Mouse AAA sham PPE + scr-miR PPE + anti-24 PPE + pre-24
miR-24 Modulation in AngII-Induced AAA 1000 ng/min/kg of AngII for 28 days
miR-24 Regulation in vitro
miR and Gene Expression in Human AAA
miR-24 and YKL-40 in Plasma * # * *
Pathology of AAA - Therapeutic Opportunities • Transmural inflammation miR-24 • SMC phenotypic changes and apoptosis miR-21 • Impaired ECM remodeling miR-29b • Loss of elastin layer integrity à Progressive luminal expansion pre-24 scr-miR Sci Transl Med 2012 J Clin Invest 2012 unpublished
Conclusions • microRNAs regulate gene expression in the aortic wall • miR-24 regulates inflammatory activity (and remodeling) during AAA development via YKL-40 • miR-24 and YKL-40 are differentially regulated in human AAA tissue samples • YKL-40 is a novel biomarker of AAA disease severity • Modulating miR-24 represents a new therapeutic option to control inflammatory processes during AAA development • Effect of systemic miR-24 modulation is yet unknown à local delivery mechanisms desirable

Recommend

Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm David N. Duddleston, MD David N. Duddleston,

Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm David N. Duddleston, MD David N. Duddleston, MD VP and Medical Director VP and Medical Director Southern Farm Bureau Life Southern Farm Bureau Life Jackson, Mississippi Jackson,

288 views • 12 slides

An abdominal aortic aneurysm (AAA) screening programme to improve health outcomes for Mori Dr

An abdominal aortic aneurysm (AAA) screening programme to improve health outcomes for Mori Dr Da le Bra mle y, Chie f E xe c utive Dr Pe te r Sa ndifo rd, Clinic a l Dire c to r He a lth Ga in The problem He a lth ine q ua litie s b e twe e

392 views • 10 slides

Ruptured abdominal aortic aneurysm masquerading as isolated hip pain: an unusual presentation

C ASE R EPORT R APPORT DE CAS Ruptured abdominal aortic aneurysm masquerading as isolated hip pain: an unusual presentation Sriram Vaidyanathan, MRCS; * Himanshu Wadhawan, MRCS; * Pedro Welch; Murad El-Salamani, FRCS ABSTRACT The

149 views • 4 slides

The Role of Endovascular The Role of Endovascular Repair Repair Repair Repair John Rose John

Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm A service in need of surgery? A service in need of surgery? The Role of Endovascular The Role of Endovascular Repair Repair Repair

468 views • 31 slides

GENDER BASED DIFFERENCES IN ABDOMINAL AORTIC ANEURYSM (AAA) RUPTURE -Srikrishna Varun Malayala,

GENDER BASED DIFFERENCES IN ABDOMINAL AORTIC ANEURYSM (AAA) RUPTURE -Srikrishna Varun Malayala, MBBS Mentors: -Khalid J Qazi, MD, MACP -Paul M Anain, MD 1. http:/ / a o rtic ste nts.c o m/ wha t-is-a b do mina l-a o rtic -a ne urysm/ (05/

565 views • 34 slides

National Update Nursing Day September 2015 Lisa Summers Programme Manager NHS Abdominal

Abdominal Aortic Aneurysm NHS AAA Screening Programme National Update Nursing Day September 2015 Lisa Summers Programme Manager NHS Abdominal Aortic Aneurysm Screening Programme Part of Public Health England Nurse Assessment Data

1.1k views • 98 slides

Aortic Syndromes Aortic Aneurysm Aortic Dissection Intramural Hematoma (IMH)

6/10/2013 Current Trends in Aortic Syndromes Aortic Syndromes Torin P. Fitton, MD Division of Cardiothoracic Surgery Lahey Clinic NO DISCLOSURES Aortic Syndromes Aortic Aneurysm Aortic Dissection Intramural Hematoma (IMH)

409 views • 25 slides

Stent Graft Change Detection after Endovascular Abdominal Aortic Aneurysm Repair

375 views • 14 slides

Loves labour lost !!! HYBRID REPAIR OF COMPEX ABDOMINAL AORTIC ANEURYSM Anil Dhall VS Bedi

Loves labour lost !!! HYBRID REPAIR OF COMPEX ABDOMINAL AORTIC ANEURYSM Anil Dhall VS Bedi Disclosure Statement of Financial Interest I, ANIL DHALL, DO NOT have a financial interest/arrangement or affiliation with one or more

1.31k views • 72 slides

ABDOMINAL PAIN Location Work-up Acute pain syndromes Chronic pain syndromes

ABDOMINAL PAIN Location Work-up Acute pain syndromes Chronic pain syndromes Epigastric Pain PUD GERD MI AAA- abdominal aortic aneurysm Pancreatic pain Gallbladder and common bile duct obstruction Right

821 views • 26 slides

Hemodynamic and Biomarkers for Clinical Risk Stratification of Ascending Thoracic Aortic Aneurysm

Hemodynamic and Biomarkers for Clinical Risk Stratification of Ascending Thoracic Aortic Aneurysm with Bicuspid Aortic Valve Salvatore Pasta, PhD The Significance of Bicuspid Aortic Valve Cardiovascular diseases (CVD) causes each year over 4

312 views • 12 slides

Consensus Guidelines for Timing and Treatment of Abdominal Aortic Aneurysms S. Jay Mathews, MD,

Consensus Guidelines for Timing and Treatment of Abdominal Aortic Aneurysms S. Jay Mathews, MD, MS, FACC Director, CCL, Structural Heart, PERT Programs Manatee Memorial Hospital, Bradenton, FL Disclosure Statement of Financial Interest Within

430 views • 17 slides

COMPLEX PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE CORONARY INTERVENTION FOR ACUTE CORONARY

COMPLEX PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE CORONARY INTERVENTION FOR ACUTE CORONARY SYNDROME IN A PATIENT WITH THORACIC AORTIC ANEURYSM AFTER STENT GRAFT AORTIC ANEURYSM AFTER STENT GRAFT TREATMENT Zu-Yin Chen, MD; Tao-Cheng Wu, MD

467 views • 17 slides

CT guided direct thrombin injection to treat type II endoleak following endovascular repair of

CT guided direct thrombin injection to treat type II endoleak following endovascular repair of abdominal aortic aneurysm Emmanuel Karras , Alexandros Tzeferakos, Georgios Kyprianos, Ioanna Vlachou, Sotirios Giannakakis Georgios Giannikouris,

450 views • 14 slides

New Devices and Future Therapies In the Treatment of Abdominal Aortic Aneurysms Robert M.

New Devices and Future Therapies In the Treatment of Abdominal Aortic Aneurysms Robert M. Bersin, MD Disclosure Statement of Financial Interest I, Robert M. Bersin, have a financial interest/arrangement or affiliation with the following

683 views • 20 slides

TCT 2009 Back ground The efficacy of endovascular stent-graft placement for thoracic aortic

Midterm Outcome of Inoue Stent Graft for the Treatment of Thoracic Aortic Aneurysm and Dissections Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Junichi Tazaki Takeshi Kimura Department of Cardiovascular

371 views • 20 slides

27 November 2015 Jan Yates Regional Head of QA,SQAS(London) Public Health England is responsible

Quality Assurance (London) Abdominal Aortic Aneurysm Screening SQAS (London) Network Day 27 November 2015 Jan Yates Regional Head of QA,SQAS(London) Public Health England is responsible for the NHS Screening Programmes Housekeeping Fire

684 views • 35 slides

Problems with open approach History of popliteal aneurysm repair 1888, Rudolph Matas first

4/3/2014 History of popliteal aneurysm repair Outcomes for Endovascular Treatment of Popliteal Aneurysms 2nd century AD, Antyllus, the Father of Aneurysm are Similar to Open Repair Surgery performed the first recorded aneurysm repair

185 views • 5 slides

Valvular Heart Disease: Aortic Stenosis and Aortic Insufficiency Ivan Anderson, MD RIHVH

Valvular Heart Disease: Aortic Stenosis and Aortic Insufficiency Ivan Anderson, MD RIHVH Cardiology Outline Structure of the Aortic Valve Causes of Aortic Stenosis and Insufficiency Prognosis Assessment and Follow-up of Aortic

676 views • 49 slides

Aortic Valve Disease and Trans-catheter Aortic Valve Replacement The Latest Treatment

Aortic Valve Disease and Trans-catheter Aortic Valve Replacement The Latest Treatment Option Sonia Scalf, RN, CVSN Structural Heat Nurse Coordinator Vanderbilt Heart and Vascular Institute Aortic Stenosis Aortic stenosis is the

444 views • 26 slides

The Aortic Valve and The Aortic Valve and The Aortic Root in The Aortic Root in Type A Aortic

The Aortic Valve and The Aortic Valve and The Aortic Root in The Aortic Root in Type A Aortic Dissections Type A Aortic Dissections Optimal Surgical Surgical Optimal Technique Technique Type A aortic aortic dissection dissection

981 views • 78 slides

Aortic Valve: investigation by engineering tools Universit degli Studi di Pavia - Structural

Biomechanics Aortic Valve: investigation by engineering tools Universit degli Studi di Pavia - Structural Mechanics Department 1 Aortic Valve AORTIC VALVE SPARING PROCEDURE Effects of Aortic root delation - Coaptazion area reduction -

100 views • 7 slides

ABDOMINAL TRAUMA Trauma Intensive Care Unit Objectives At the end of this presentation, the

ABDOMINAL TRAUMA Trauma Intensive Care Unit Objectives At the end of this presentation, the participants will be able to: Describe abdominal anatomy and functions of individual abdominal organs Differentiate between blunt and penetrating

958 views • 72 slides

Blunt abdominal trauma and the absence of abdominal bruising Implications in critical care

Blunt abdominal trauma and the absence of abdominal bruising Implications in critical care Presenter Dr Brendon Bowkett Author(s): Goddard L. 1 , Bowkett B. 2 , Kenwright D. 3 Institute(s): 1 Wellington Childrens Hospital, Clinical School,

455 views • 18 slides