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MedAustron Ion Therapy and Research Centre Sylvia Gruber, PhD - PowerPoint PPT Presentation

Jun 22, 2023 •161 likes •721 views

Radiobiology Research at MedAustron Ion Therapy and Research Centre Sylvia Gruber, PhD Medical University of Vienna High Energy Physics Seminars Imperial College London Contents The MedAustron Centre A Brief History

  1. Radiobiology Research at MedAustron – Ion Therapy and Research Centre Sylvia Gruber, PhD Medical University of Vienna High Energy Physics Seminars Imperial College London

  2. Contents

  3. The MedAustron Centre • • •

  4. A Brief History

  5. Tumour Therapy Options

  6. Ion Beam Therapy: Physical Motivation Superior dose distribution • • •

  7. Ion Beam Therapy: Biological Motivation Increased Effectiveness • •  •

  8. Ion Beam Therapy: Indications • • •

  9. Facility Layout

  10. Pencil Beam Scanning

  11. Irradiation Rooms

  12. Irradiation Rooms – Patient Treatment

  13. Current Treamtents at MedAustron Head & Neck Skull Base Sarcoma CNS Pediatric Tumours Prostate Re-Irradiation • •

  14. Irradiation Rooms - Research

  15. Irradiation Room 1 • • • • • • •

  16. Non Clinical Research Groups

  17. Applied and Translational Radiobiology Team

  18. Timeline of ATRAB at MedAustron 53BP1

  19. Mission Broadening of the therapeutic index • •

  20. Focus of Radiobiological Research at MedAustron Challenging the RBE • • • • •

  21. RBE Dependencies: Tissue Characteristics

  22. RBE Dependencies: LET •

  23. RBE Dependencies: LET

  24. RBE Dependencies: Target Coverage Energy • • • •

  25. RBE Dependencies: Target Coverage Energy and LET • • • • • • 66.5 – 135.6 MeV • 137.2 – 180.1 MeV

  26. Dosimetry Aspects

  27. Dosimetry Aspects 

  28. Squamous Cell Carcinoma Cells

  29. Normal Skin Keratinocytes

  30. Prostate Carcinoma Cells

  31. A 3D World

  32. Advances Cell Culture Models: Multicellular Tumor Spheroids

  33. Advances Cell Culture Models: Multicellular Tumor Spheroids

  34. Therapy-relevant Factor: Hypoxia Indirect vs. direct DNA damage • • • • •

  35. Spheroid Size determines Oxygen Gradient • •

  36. DNA Damage: Influence of 3D Tissue Architecture Squamous Cell Carcinoma Spheroids

  37. Tumor Spheroids: Irradiation Setup •

  38. Tumor Spheroids: Irradiation Setup

  39. Résumé and Workaround • • • • •

  40. Advances Cell Culture Models: Biomimetic Epithelium

  41. Radiobiology of Normal Tissue Reactions functional layer germinal layer submucosa tongue muscle (n th gen)

  42. The Oral Mucositis Mouse Model

  43. Normal Tissue Protection: Dermatan Sulfate for OM Mitigation

  44. DS-mediated radioprotection: not stimulation of proliferation but junctions Fraction of BrdU positive cells (%) / 140 200 14 Epithelial cell numbers (%) *** Epithelial thickness (µm) germinal epithelial layer 12 120 150 10 100 *** * 8 ** ** 100 6 80 4 50 60 2 40 0 0 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14 days after onset of irradiation days after onset of irradiation days after onset of irradiation

  45. DS-mediated radioprotection: reduced hypoxia

  46. DS-mediated radioprotection: reduced inflammation

  47. MedAustron - Outlook • • •

  48. Research Outlook – 2019-2021 Correlation of LET and signalling events • • • • •

  49. Acknowledgement http://www.meduniwien.ac.at/hp/radonc/ • • • • • • The financial support by the Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development is gratefully acknowledged.

  50. Supplementary

  51. Accelerator Components – Ion Sources • • • • • • • •

  52. Accelerator components – Low Energy Beam Transfer Line • • • • • •

  53. Accelerator components – Linear Accelerator • • • • •

  54. Accelerator components – Synchotron • • • • • • • •

  55. Accelerator components – High Energy Transfer Line • • • • • •

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