Maxwells demons, protein molecular machines, and information - PowerPoint PPT Presentation

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1st International Electronic Conference on Entropy and Its applications 3 21 November 2014 Maxwells demons, protein molecular machines, and information processing in biophysic Michal Kurzynski & Przemyslaw Chelminiak Faculty of

1st International Electronic Conference on Entropy and Its applications 3 – 21 November 2014 Maxwell’s demons, protein molecular machines, and information processing in biophysic Michal Kurzynski & Przemyslaw Chelminiak Faculty of Physics, A. Mickiewicz University, Poznan, Poland
Acto-myosin motor http://homes.mpimf-heidelberg.mpg.de/~holmes/newfigs/7+8.gif
ATP synthase J. Weber, BBA 1757 , 1162 (2007)
Quinol : cytochrome c synthase Proton pump http://news.uns.purdue.edu/uns/images/cramer.photo2.jpeg
Machine: any physical system that enables two other systems to perform work on one another Molecular machines, like chemical reactions and Darwinian evolution, act due to thermal fluctuations
Maxwell’s demon Maxwell, 1871
Szilard engine with information processing • Szilard, 1929 • Brillouin, 1956 • Landauer, 1961 • Penrose, 1970 • Bennett, 1982 • Sagawa, Ueda, 2010 isothermal gas decompression D E = D F + T D S = W + Q = 0 no dissipation
Szilard engine without information processing • Popper, Feyerabend, 1966 • Alicki, 2014
Ratchet and pawl machine • Smoluchowski, 1912 • Feynman, 1966
Flashing ratchet • A. F. Huxley, 1957, 1971 • Cordova, Ermentrout, Random versus Oster, 1992 controlled transitions • Astumian, Bier, 1994 • Prost, Chauwin, Peliti, Ajdari, 1994 • Cao, Dinis, Parrondo, 2004 • Howard, 2001, 2006 Brownian ratchet Power stroke
Friction ( energy dissipation ) is necessary for any machine to be controlled
Stationary isothermal machine (free energy trasducer) macroscopic versus nanoscopic
Biological chemo-chemical machine
Peptide b 3s 20 residues 1 m s MD trajectory at 330 K (melt. temp.) HH – helical TR - trap TSE – trans. state FS – folded state Rao, Caflisch (2004)
Can the value of e = J 2 / J 1 be higher than unity? Number of actomyosin motor steps per ATP molecule hydrolyzed Kitamura, Tokunaga, Iwane, Yanagida, 1999
Jarzynski,1997 Fluctuation theorem Crooks, 1999 Searles, Evans, 1999 Andrieux, Gaspard, 2007 Sagawa, Ueda, 2010
• The fluctuation theorem for ( j 1, j 2) is satisfied • Degree of coupling higher than unity, J 2 > J 1 , is possible • For J 2 - J 1 , the generalized fluctuation theorem is satisfied
Myosin II – partly unfolded after ATP binding http://meds.queensu.ca/biochem/assets/kanelis.jpg
Ras: G-protein signal transducer activation of transcription factors proto-oncogene of lung cancer http://upload.wikimedia.org/wikipedia/commons/2/26/Ras-Structure.png
http://upload.wikimedia.org/wikipedia/commons/b/bb/P53.png Transcription factor p53 (tumor supressor)

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