Manil Chouhan Manil Chouhan
Tesla is a measure of magnetic field strength
The magnetic field of the earth is 0.00005 T
The average fridge magnet is 0.001 T
1.5 T
3.0 T
3.0 T?
Why? Why?
High Resolution ‐ Head and Neck SCC
Whole Body T2 ‐ Lymphoma
Whole Body T1 ‐ Prostate Cancer
Conventional Assessment ‐ Lymphoma MRI
Conventional Assessment ‐ Lymphoma MRI
Diffusion Spectroscopy Dynamic contrast enhancement (DCE) Susceptibility weighted imaging Equilibrium contrast imaging Arterial spin labelling R2* imaging Flow imaging Blood-oxygen level dependent imaging Fat ‐ water quantitation dynamic
Thermal energy causes Thermal energy causes Thermal energy causes diffusion of water molecules diffusion of water molecules of water molecules diffusion
Cellular barriers cause restriction Cellular barriers cause restriction restriction Cellular barriers cause to water movement to water movement to water movement
Diffusion ‐ Head and Neck SCC
Diffusion ‐ Crohn’s Disease
Diffusion ‐ Acute Colitis Pre Tx b0 b50 b200 b400 Post Tx b0 b50 b200 b400
K trans V e
DCE ‐ Prostate Cancer
DCE ‐ Lymphoma Spleen
Small Bowel Motility
Vocal Cord Movement
How? How?
50% research 50% clinical
CRBC funding � Purchase and installation (50%) � Underwriting of running costs on a tapering scale until grant income sufficient ‐ Senior Lectureships in Radiology and Medical Physics ‐ Research Radiographers ‐ Administation staff � 3 years
� Final approval summer 2010 � Detailed scanner evaluation and tendering process � Phillips scanner chosen Q4 2010 � Installed Q1 ‐ Q2 2011
Research Applications Research Applications
Imaging Novel sequences, tracers, Novel sequences, tracers, Pre clinical Pre clinical computational techniques eg computational techniques eg registration, motion correction. registration, motion correction. Novel therapies Novel therapies First in man First in man Pilot studies Pilot studies Initial Validation/ proof Initial Validation/ proof of concept of concept Single site clinical trials Single site clinical trials Clinical trials Clinical trials Multisite clinical trials ‐ health Multisite clinical trials ‐ health Clinical implementation Clinical implementation economics, advanced statistics, economics, advanced statistics, health psychology health psychology
CMIC CABI Medical physics R espiratory, A naesthesia, C ritical NeuroImaging Care, and E xercise, Neurodegeneration Sports & Health Infection and Neurodiagnostics Inflammation Body imaging cancer Gastroenterology and Hepatology Cardiovascular Disease Women’s Health Neurotherapeutics Education, Oral health Ear, Nose Cellular and Training and and Throat) Gene Therapy Biostatistics
Quantitative MRI for Crohn’s disease ‐ S Taylor, S Halligan, A Windsor, S Bloom Detection of vulnerable plaques in patients with acute coronary syndrome ‐ P Meier, R Botnar, A Indermuehle Neuroprotective effects of hypothermia and Xenon after perinatal brain injury ‐ N Robertson, E Cady Clinical relevance of microbleeds in stroke ‐ D Werring, R Jager, M Brown, H Houlden, T Yousry, J Hardy Postnatal brain growth and early infancy outcomes in very preterm children ‐ N Marlow, S Johnson, M de Haan, S Ourselin, N Robertson, X Golay Laryngeal Reinnervation versus Type I Thyroplasty in Unilateral Vocal Fold Paralysis Patients ‐ M Birchall, M Mat Baki, T Beale Multi-parametric prostate MRI (PROMIS) ‐ M Emberton, H Ahmed, A Kirkham, C Allen MRI for detection and characterisation of lung nodules ‐ S Punwani, S Janes, N Navani, P Shaw, M Taylor, N Bell
MR assessment of liver haemodynamics in chronic liver disease
The future... The future...
Cancer centre UCH Basic Science Basic Science 3T MRI 3T MRI PET/MRI Clinical Translation Clinical Translation
The UCLH 3T MRI team The UCLH 3T MRI team
• David Atkinson - Medical Physicist • Uma Kumar - MRI Radiographer Nicola Stevens - MRI Radiographer • • Shonit Punwani - Radiologist • Mara Balcombe – 3T Research Co-ordinator (not shown) 3tresearchimagingrequests@uclh.nhs.uk
Questions? Questions?
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